New Tic Disorder in a Child With Cystic Fibrosis Treated With Elexacaftor/Tezacaftor/Ivacaftor.
Document Type
Article
Publication Date
2-2024
Identifier
DOI: 10.5863/1551-6776-29.1.82; PMCID: PMC10849685
Abstract
The widespread use of highly effective cystic fibrosis transmembrane-conductance regulator -modulator therapy has dramatically altered the lives of individuals with cystic fibrosis. Clinical trials leading to -modulator approval by the US Food and Drug Administration demonstrated improvements in major -outcome measures including pulmonary function, gastrointestinal symptoms, and quality of life. Subsequent clinical experience has confirmed significant improvement across these domains. Adverse effects reported -during clinical trials included headache and dizziness amongst others including upper respiratory infections, abdominal pain, diarrhea, rash, and elevated serum transaminases. Post marketing clinical experience has suggested that there may be additional central nervous system adverse effects resulting from modulator therapy. Reported events after initiation of cystic fibrosis transmembrane-conductance regulator modulator treatment include headaches and increased prevalence of mental health concerns including anxiety and depression. We report a new tic disorder in a 7-year-old girl with cystic fibrosis treated with elexacaftor/tezacaftor/ivacaftor.
Journal Title
J Pediatr Pharmacol Ther
Volume
29
Issue
1
First Page
82
Last Page
84
Keywords
CFTR modulator; adverse event; cystic fibrosis; elexacaftor/tezacaftor/ivacaftor; tics
Recommended Citation
Duehlmeyer SR, Elson EC, Oermann CM. New Tic Disorder in a Child With Cystic Fibrosis Treated With Elexacaftor/Tezacaftor/Ivacaftor. J Pediatr Pharmacol Ther. 2024;29(1):82-84. doi:10.5863/1551-6776-29.1.82