Post-transplant recurrence of focal segmental glomerular sclerosis: consensus statements.

Document Type

Article

Publication Date

3-2024

Identifier

DOI: 10.1016/j.kint.2023.10.017

Abstract

Focal segmental glomerular sclerosis (FSGS) is 1 of the primary causes of nephrotic syndrome in both pediatric and adult patients, which can lead to end-stage kidney disease. Recurrence of FSGS after kidney transplantation significantly increases allograft loss, leading to morbidity and mortality. Currently, there are no consensus guidelines for identifying those patients who are at risk for recurrence or for the management of recurrent FSGS. Our work group performed a literature search on PubMed/Medline, Embase, and Cochrane, and recommendations were proposed and graded for strength of evidence. Of the 614 initially identified studies, 221 were found suitable to formulate consensus guidelines for recurrent FSGS. These guidelines focus on the definition, epidemiology, risk factors, pathogenesis, and management of recurrent FSGS. We conclude that additional studies are required to strengthen the recommendations proposed in this review.

Journal Title

Kidney international

Volume

105

Issue

3

First Page

450

Last Page

463

MeSH Keywords

Adult; Humans; Child; Glomerulosclerosis, Focal Segmental; Sclerosis; Kidney Transplantation; Transplantation, Homologous; Nephrotic Syndrome; Recurrence; Plasmapheresis

Keywords

focal segmental glomerular sclerosis; plasmapheresis; post-transplant

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