Association of mental health-related patient reported outcomes with blood pressure in adults and children with primary proteinuric glomerulopathies.

Document Type

Article

Publication Date

4-2024

Identifier

DOI: 10.1007/s40620-024-01919-6

Abstract

INTRODUCTION: The prevalence of mental health disorders including anxiety and depression is increasing and is linked to hypertension in healthy individuals. However, the relationship of psychosocial patient-reported outcomes on blood pressure (BP) in primary proteinuric glomerulopathies is not well characterized. This study explored longitudinal relationships between psychosocial patient-reported outcomes and BP status among individuals with proteinuric glomerulopathies.

METHODS: An observational cohort study was performed using data from 745 adults and children enrolled in the Nephrotic Syndrome Study Network (NEPTUNE). General Estimating Equations for linear regression and binary logistic analysis for odds ratios were performed to analyze relationships between the exposures, longitudinal Patient-Reported Outcome Measurement Information System (PROMIS) measures and BP and hypertension status as outcomes.

RESULTS: In adults, more anxiety was longitudinally associated with higher systolic and hypertensive BP. In children, fatigue was longitudinally associated with increased odds of hypertensive BP regardless of the PROMIS report method. More stress, anxiety, and depression were longitudinally associated with higher systolic BP index, higher diastolic BP index, and increased odds of hypertensive BP index in children with parent-proxy patient-reported outcomes.

DISCUSSION/CONCLUSION: Chronically poor psychosocial patient-reported outcomes may be significantly associated with higher BP and hypertension in adults and children with primary proteinuric glomerulopathies. This interaction appears strong in children but should be interpreted with caution, as multiple confounders related to glomerular disease may influence both mental health and BP independently. That said, access to mental health resources may help control BP, and proper disease and BP management may improve overall mental health.

Journal Title

Journal of nephrology

Volume

37

Issue

3

First Page

647

Last Page

660

MeSH Keywords

Humans; Male; Female; Patient Reported Outcome Measures; Child; Blood Pressure; Adult; Hypertension; Adolescent; Anxiety; Depression; Mental Health; Middle Aged; Proteinuria; Longitudinal Studies; Young Adult; Stress, Psychological

Keywords

Blood pressure; Glomerular disease; Mental health; PROMIS

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