The impact of early tracheostomy on neurodevelopmental outcomes of infants with severe bronchopulmonary dysplasia exposed to postnatal corticosteroids.

Document Type

Article

Publication Date

7-2024

Identifier

DOI: 10.1038/s41372-023-01864-5

Abstract

OBJECTIVE: To compare the cognitive, language and motor scores of infants with severe BPD exposed to postnatal corticosteroids (PCS) and had early (ET), late (LT) or no tracheostomy (NT).

METHODS: Retrospective study was designed to compare the developmental outcomes of 71 infants born between 2010 and 2017 with severe BPD exposed to PCS and had ET (≤122 days), LT (>122 days), or NT.

RESULTS: Cognitive scores were lower in LT versus NT and ET (p = 0.050); motor scores were worse in LT versus NT and ET (p = 0.004). Dexamethasone use was higher in LT versus NT and ET (p = 0.040). Adjusted for PCS, odds for major cognitive impairment were 90% less in ET versus LT. Trend for improved language and motor outcomes was seen in ET versus LT.

CONCLUSION: Infants with severe BPD exposed to PCS and had ET had significantly better cognitive, and trend toward improved language and motor outcomes.

Journal Title

Journal of perinatology : official journal of the California Perinatal Association

Volume

44

Issue

7

First Page

979

Last Page

987

MeSH Keywords

Humans; Bronchopulmonary Dysplasia; Retrospective Studies; Female; Tracheostomy; Male; Infant, Newborn; Infant; Dexamethasone; Adrenal Cortex Hormones; Cognition; Child Development; Glucocorticoids; Infant, Premature; Neurodevelopmental Disorders; Cognitive Dysfunction

Keywords

Bronchopulmonary Dysplasia; Retrospective Studies; Tracheostomy; Dexamethasone; Adrenal Cortex Hormones; Cognition; Child Development; Glucocorticoids; Neurodevelopmental Disorders; Cognitive Dysfunction

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