Computed tomography-guided percutaneous cryoablation of hereditary adrenal pheochromocytoma in three patients.

Creator(s)

Emily Griffing, Children's Mercy Kansas CityFollow
Brenton Reading, Children's Mercy HospitalFollow
Francesco De Luca, Children's Mercy HospitalFollow
Daniel Agne, Children's Mercy Kansas CityFollow
David Juang, Children's Mercy HospitalFollow
Kelsee Halpin, Children's Mercy Kansas CityFollow

Document Type

Article

Publication Date

7-26-2024

Identifier

DOI: 10.1515/jpem-2024-0033

Abstract

OBJECTIVES: Pheochromocytomas (PHEO) are neuroendocrine tumors rarely diagnosed in children. We are reporting on the management challenges of three adolescent patients who present with hereditary PHEO.

CASE PRESENTATION: The index patient and his male sibling presented with bilateral PHEO, while a third patient presented with a unilateral PHEO, all associated with von Hippel-Lindau (VHL) syndrome. The patients were treated with computed tomography (CT)-guided percutaneous cryoablation (CRA) of the adrenal lesions, with varying degrees of success.

CONCLUSIONS: CT-guided percutaneous CRA of hereditary PHEO has not been reported in the pediatric population and may represent a novel treatment strategy that reduces the risk of intraprocedural complications and adrenal insufficiency (AI).

Journal Title

Journal of pediatric endocrinology & metabolism : JPEM

Volume

37

Issue

7

First Page

657

Last Page

662

MeSH Keywords

Humans; Pheochromocytoma; Adrenal Gland Neoplasms; Cryosurgery; Male; Adolescent; Tomography, X-Ray Computed; Female; Child; Prognosis; von Hippel-Lindau Disease

Keywords

adrenal insufficiency; pheochromocytoma; von Hippel–Lindau syndrome

Recommended Citation

Griffing E, Reading B, De Luca F, Agne D, Juang D, Halpin K. Computed tomography-guided percutaneous cryoablation of hereditary adrenal pheochromocytoma in three patients. J Pediatr Endocrinol Metab. 2024;37(7):657-662. Published 2024 May 30. doi:10.1515/jpem-2024-0033