Daily glucose variability is associated with intrahepatic fat content, β cell sensitivity, and biomarkers of glycolysis in youth with obesity.

Document Type

Article

Publication Date

1-2025

Identifier

DOI: 10.1002/oby.24175; PMCID: PMC11666407

Abstract

OBJECTIVE: Pediatric obesity is associated with insulin resistance, which, in turn, impacts glucose and lipid metabolism. This study sought to assess how glucose variability relates to intrahepatic fat content, β cell insulin sensitivity, and glycolysis in youth with obesity.

METHODS: A total of 27 youth with obesity (11 girls, BMI percentile, median [25th-75th percentiles]: 99.0 [97.9-99.0]) wore a continuous glucose monitoring device for 10 days and underwent a 3-h oral glucose tolerance test. β cell function was assessed using the oral minimal model, and liver proton density fat fraction was measured by magnetic resonance imaging.

RESULTS: Average sensor-derived glucose and glucose standard deviation (STDEV) and coefficient of variation (CV) were associated with liver proton density fat fraction (p = 0.0130, p = 0.0005, and p = 0.0028, respectively). First-phase insulin secretion, basal insulin secretion, and insulin sensitivity were associated with STDEV (p = 0.0344, p = 0.0091, and p = 0.0031, respectively) and CV (p = 0.0128, p = 0.0012, and p = 0.0022, respectively). STDEV and CV were also associated with 2-h glucose (p = 0.0067 and p = 0.0324, respectively) and plasma lactate (p = 0.0030 and p = 0.0123, respectively).

CONCLUSIONS: Daily glucose variability is associated with the degree of intrahepatic fat content, postprandial glucose, and plasma lactate concentrations.

Journal Title

Obesity (Silver Spring)

Volume

33

Issue

1

First Page

116

Last Page

124

MeSH Keywords

Humans; Female; Male; Insulin Resistance; Insulin-Secreting Cells; Child; Pediatric Obesity; Adolescent; Glycolysis; Liver; Blood Glucose; Glucose Tolerance Test; Biomarkers; Magnetic Resonance Imaging; Insulin

PubMed ID

39658509

Keywords

Insulin Resistance; Insulin-Secreting Cells; Pediatric Obesity; Glycolysis; Liver; Blood Glucose; Glucose Tolerance Test; Biomarkers; Magnetic Resonance Imaging; Insulin

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