Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates.

Document Type

Article

Publication Date

1-1-2025

Identifier

DOI: 10.1097/INF.0000000000004501

Abstract

The genetic basis of neonatal COVID-19 infection, which exhibits a range of severity, has not been investigated. We identified both shared and unique genetic variants involved in antiviral immune responses through whole exome sequencing of an infant who developed severe COVID-19 pneumonia and multisystem inflammatory syndrome and the twin brother also positive for severe acute respiratory syndrome-coronavirus-2, but with only moderate respiratory symptoms.

Journal Title

The Pediatric infectious disease journal

Volume

44

Issue

1

First Page

44

Last Page

46

MeSH Keywords

Humans; COVID-19; Exome Sequencing; Infant, Newborn; Male; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Female; Twins; Severity of Illness Index

PubMed ID

39082788

Keywords

COVID-19; Exome Sequencing; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Twins; Severity of Illness Index

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