Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates.
Document Type
Article
Publication Date
1-1-2025
Identifier
DOI: 10.1097/INF.0000000000004501
Abstract
The genetic basis of neonatal COVID-19 infection, which exhibits a range of severity, has not been investigated. We identified both shared and unique genetic variants involved in antiviral immune responses through whole exome sequencing of an infant who developed severe COVID-19 pneumonia and multisystem inflammatory syndrome and the twin brother also positive for severe acute respiratory syndrome-coronavirus-2, but with only moderate respiratory symptoms.
Journal Title
The Pediatric infectious disease journal
Volume
44
Issue
1
First Page
44
Last Page
46
MeSH Keywords
Humans; COVID-19; Exome Sequencing; Infant, Newborn; Male; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Female; Twins; Severity of Illness Index
PubMed ID
39082788
Keywords
COVID-19; Exome Sequencing; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Twins; Severity of Illness Index
Recommended Citation
Godwin J, Daniel J 4th, Chavez-Bueno S, Sampath V. Insight Into Severe Neonatal COVID-19 Gained Through Whole Exome Sequencing of Twin Neonates. Pediatr Infect Dis J. 2025;44(1):44-46. doi:10.1097/INF.0000000000004501