Document Type

Article

Publication Date

1-2025

Identifier

DOI: 10.1016/j.jclinepi.2024.111578

Abstract

OBJECTIVES: Trustworthy guidelines rely on systematic reviews of the best available published evidence. The GRADE (Grading of Recommendations Assessment, Development, and Evaluation) Working Group has provided guidance about developing evidence-based recommendations when published direct evidence is lacking. In this article, we provide a case example as an alternate solution to generate primary data using registries prior to collecting expert evidence.

STUDY DESIGN AND SETTING: When direct published literature was absent, a team of clinical and statistical expertise can utilize registries, when available, for primary data generation in a way that allows for answering clinically important questions.

RESULTS: Out of 54 questions prioritized by a guideline development for the prevention and management of peritoneal dialysis-associated infections in children, 25 questions had no evidence to inform them. The use of unpublished registry data served as a primary source of information to answer 12 of the 25 questions and provided additional information for nine questions for which at least one published study was available.

CONCLUSION: This article extends our previous GRADE note for scenarios of "no" evidence, highlighting the value of generating primary evidence using unpublished registry data when relevant registries and resources allow. This approach can be of particular value when addressing conditions that are rare or from populations that are considered vulnerable, while emphasizing the importance of being transparent regarding the reporting of raw data and the analysis plan in the event of reporting unpublished work.

Journal Title

Journal of clinical epidemiology

Volume

177

First Page

111578

Last Page

111578

MeSH Keywords

Registries; Humans; Evidence-Based Medicine; Peritoneal Dialysis; Practice Guidelines as Topic; GRADE Approach; Child

PubMed ID

39442676

Keywords

Data; Evidence; GRADE; Guideline; Registry; Systematic review

Comments

This article is available under the Creative Commons CC-BY-NC license and permits non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited.

Publisher's Link: https://www.jclinepi.com/article/S0895-4356(24)00334-2/fulltext

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