Prevalence and Genetic Diversity of Adenovirus 40/41, Astrovirus, and Sapovirus in Children With Acute Gastroenteritis in Kansas City, 2011-2016.

Creator(s)

Marta Diez-Valcarce
Jennifer L. Cannon
Hannah Browne
Kenny Nguyen
Christopher J. Harrison
Mary Moffatt, Children's Mercy HospitalFollow
Kirsten Weltmer, Children's Mercy Kansas CityFollow
Brian R. Lee, Children's Mercy HospitalFollow
Ferdaus Hassan
Debarpan Dhar, Children's Mercy Kansas CityFollow
Mary E. Wikswo
Daniel C. Payne
Aaron T. Curns
Rangaraj Selvarangan, Children's Mercy HospitalFollow
Jan Vinjé

Document Type

Article

Publication Date

2-4-2025

Identifier

DOI: 10.1093/infdis/jiae251

Abstract

BACKGROUND: Most acute gastroenteritis (AGE) episodes in children in the United States are attributed to norovirus, whereas very little information is available on adenovirus 40/41 (AdV40/41), astrovirus, or sapovirus. The New Vaccine Surveillance Network (NVSN) conducted prospective, active, population-based AGE surveillance in young children.

METHODS: We tested and typed stool specimens collected between December 2011 and June 2016 from 1 NVSN site in Kansas City for the 3 viruses, and calculated hospitalization and emergency department (ED) detection rates.

RESULTS: Of 3205 collected specimens, 2453 (76.5%) were from AGE patients (339 inpatients and 2114 ED patients) and 752 (23.5%) were from healthy controls. In patients with AGE, astrovirus was detected in 94 (3.8%), sapovirus in 252 (10.3%), and AdV40/41 in 101 (4.5%) of 2249 patients. In healthy controls, astrovirus was detected in 13 (1.7%) and sapovirus in 15 (2.0%) specimens. Astrovirus type 1 (37.7%) and genogroup I sapoviruses (59.3%) were most prevalent. Hospitalization rates were 5 (AdV40/41), 4 (astrovirus), and 8 (sapovirus) per 100 000 childrenold, whereas ED rates were 2.4 (AdV40/41), 1.9 (astrovirus), and 5.3 (sapovirus) per 1000 childrenold.

CONCLUSIONS: Overall, AdV40/41, astrovirus, and sapovirus were detected in 18.6% of AGE in a large pediatric hospital in Kansas City.

Journal Title

The Journal of infectious diseases

Volume

231

Issue

1

First Page

186

Last Page

195

MeSH Keywords

Humans; Gastroenteritis; Sapovirus; Child, Preschool; Infant; Female; Male; Genetic Variation; Prevalence; Feces; Astroviridae Infections; Prospective Studies; Kansas; Mamastrovirus; Hospitalization; Caliciviridae Infections; Child; Adenoviruses, Human; Infant, Newborn; Adenoviridae Infections

PubMed ID

38718103

Keywords

acute gastroenteritis; adenovirus 40/41; astrovirus; genetic diversity; sapovirus

Comments

Grants and funding

• CDC-RFA-IP16-004/US Centers for Disease Control and Prevention

Recommended Citation

Diez-Valcarce M, Cannon JL, Browne H, et al. Prevalence and Genetic Diversity of Adenovirus 40/41, Astrovirus, and Sapovirus in Children With Acute Gastroenteritis in Kansas City, 2011-2016. J Infect Dis. 2025;231(1):186-195. doi:10.1093/infdis/jiae251