Histologic analysis of gonadal tissue in patients with Turner syndrome and Y chromosome material.

Creator(s)

Julia Bhuiyan
Raghuveer Kavarthapu
Mary Soliman
G Thomas Brown
Jacqueline C. Yano
Tazim Dowlut-McElroy, Children's Mercy Kansas CityFollow
Veronica Gomez-Lobo

Document Type

Article

Publication Date

2-2025

Identifier

DOI: 10.1016/j.jpurol.2024.07.016; PMCID: PMC11757796

Abstract

This study investigates gonadal histology in individuals with Turner syndrome assigned female at birth and Y-chromosome material (TS+Y) who underwent prophylactic gonadectomy. Despite case reports suggesting spontaneous menarche and pregnancies in TS+Y, this research reveals the absence of germ cells, indicating low fertility likelihood. Germ cell neoplasia in-situ was present in some patients, emphasizing a non-negligible risk of cancer precursor. As no malignancies were found even in older individuals, the study challenges the immediate need for prophylactic gonadectomy upon TS+Y diagnosis. Limited fertility benefits are suggested, emphasizing the need for further research on optimal timing and criteria for the procedure.

Journal Title

J Pediatr Urol

Volume

21

Issue

1

First Page

217

Last Page

220

MeSH Keywords

Turner Syndrome; Humans; Female; Chromosomes, Human, Y; Adolescent; Child; Child, Preschool; Adult; Young Adult; Gonads; Ovary; Infant; Retrospective Studies

PubMed ID

39089951

Keywords

Gonadal dysgenesis; Gonadal tumors; Gonadectomy; Turner syndrome

Comments

Grants and funding

• ZIA HD009005/ImNIH/Intramural NIH HHS/United States

Recommended Citation

Bhuiyan J, Kavarthapu R, Soliman M, et al. Histologic analysis of gonadal tissue in patients with Turner syndrome and Y chromosome material. J Pediatr Urol. 2025;21(1):217-220. doi:10.1016/j.jpurol.2024.07.016