Comorbidities, pharmacologic interventions, and mechanical interventions associated with mortality in isolated diastolic left heart failure: lessons from a national database.
Document Type
Article
Publication Date
1-2025
Identifier
DOI: 10.1017/S1047951124026787
Abstract
BACKGROUND: Diastolic heart failure may be noted in paediatric patients with CHD, cardiomyopathy, or malignancies requiring chemotherapy, but the available data are scarce, and often derived from adult trials or based on theoretic or anecdotal evidence.
METHODS: Data between 2016 and 2021 were obtained from Pediatric Health Information System database. PatientsPatients' demographics, comorbidities using ICD-10 codes, and pharmacologic interventions were also recorded. Univariate analysis was done in demographics, comorbidities, pharmacologic interventions, and mechanical interventions between admissions with and without mortality. Multivariable logistic regression was done for inpatient mortality and multivariable linear regression was done for total hospital length of stay in survivors.
RESULTS: Isolated diastolic heart failure comprised 0.5% of critically ill paediatric patients. A total of 121 (5%) experienced mortality among the 2,273 admissions in the final analyses. Milrinone and angiotensin converting enzyme inhibitor were found to be associated with decreased mortality. Increasing age and diuretics were associated with decreased total hospital length of stay in survivors.
CONCLUSION: In the cohort studied, isolated diastolic left heart failure has a 5% mortality. Several comorbidities and interventions are associated with increased mortality with milrinone and angiotensin converting enzyme inhibitors being associated with decreased risk of mortality. When only admissions with survival to discharge are considered, older age and diuretics are associated with lower total hospital length of stay.
Journal Title
Cardiology in the young
Volume
35
Issue
1
First Page
102
Last Page
108
MeSH Keywords
Humans; Female; Male; Child; Heart Failure, Diastolic; Adolescent; Comorbidity; Databases, Factual; Child, Preschool; United States; Retrospective Studies; Infant; Hospital Mortality; Angiotensin-Converting Enzyme Inhibitors; Milrinone; Length of Stay; Cardiotonic Agents
PubMed ID
39465538
Keywords
CHD; Diastolic heart failure; cardiovascular drugs; paediatric ICU
Recommended Citation
Loomba RS, Ikeda N, Farias JS, Villarreal EG, Flores S. Comorbidities, pharmacologic interventions, and mechanical interventions associated with mortality in isolated diastolic left heart failure: lessons from a national database. Cardiol Young. 2025;35(1):102-108. doi:10.1017/S1047951124026787
