Document Type
Article
Publication Date
2-2025
Identifier
DOI: 10.1016/j.lana.2025.100996; PMCID: PMC11804820
Abstract
BACKGROUND: Physical activity fragmentation represents the frequency of transitioning from an active to sedentary state. The prognostic information of physical activity fragmentation is unclear in Hispanics/Latinos. This study examined the association of PA fragmentation with all-cause mortality in Hispanic/Latino adults.
METHODS: We investigated 11,992 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) (18-74 yr; 52.2% women), from four United States urban communities (Bronx, New York; Chicago, Illinois; Miami, Florida; San Diego, California), that wore an accelerometer for one week. Physical activity fragmentation was calculated using the active-to-sedentary transition probability (ASTP) as the reciprocal of the average active bout duration. Daily total log-transformed activity count (TLAC) was used as a measure of total physical activity. The residual of ASTP regressed on TLAC (TLAC-adjusted ASTP) was explored to investigate the association of ASTP independent of total physical activity. Deaths were identified from annual follow-up interviews, obituary searches, or matches to the National Death Index through December 31, 2021. Cox regression models were fitted according to physical activity fragmentation.
FINDINGS: There were 745 deaths (6.2%) over a mean follow-up of 11.2 (SD 2.2) years. The highest compared to the lowest tertile of ASTP showed a HR of 1.45 (95% CI 1.10-1.92) of all-cause mortality after accounting for confounders. The mortality risk also increased for each 0.10-unit increase of ASTP, as a continuous variable, by 22% (HR 1.22; 95% CI 1.07-1.39). The results were similar considering TLAC-adjusted ASTP.
INTERPRETATION: Among Hispanic/Latino adults, more fragmented physical activity was associated with elevated all-cause mortality, independent of total physical activity volume.
FUNDING: HCHS/SOL was supported by the National Institutes of Health.
Journal Title
Lancet Reg Health Am
Volume
42
First Page
100996
Last Page
100996
PubMed ID
39925467
Keywords
Fragmentation; Hispanics; Latinos; Mortality; Physical activity; Sedentary
Recommended Citation
Mediano MFF, Mok Y, Ballew SH, et al. The association of physical activity fragmentation with all-cause mortality in Hispanics: a prospective cohort study. Lancet Reg Health Am. 2025;42:100996. Published 2025 Jan 24. doi:10.1016/j.lana.2025.100996
Comments
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Publisher's Link: https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(25)00006-7/fulltext