Document Type
Article
Publication Date
3-25-2025
Identifier
DOI: 10.1007/s00296-025-05836-0; PMCID: PMC11937059
Abstract
Hypermobile Ehlers-Danlos Syndrome (hEDS) is the most common connective tissue disorder. However, few studies exist on psychiatric and sleep disorders in pediatric patients with hEDS. This study aims to describe psychiatric and sleep disorders and evaluate their impact on health-related quality of life (HRQoL) in pediatric patients with hEDS. As part of a longitudinal study, a convenience sample of 123 pediatric patients with hEDS, were recruited at a hEDS multidisciplinary clinic in sequential order over a seven-month period. Patient-reported outcomes were completed (Patient Reported Outcomes Measurement Information System Pediatric Profile Version 2 [PROMIS], Generalized Anxiety Disorder-7 [GAD-7], Adolescent Sleep Wake Scale [ASWS], and Pediatric Quality of Life Inventory Rheumatology Module [PEDS-QL Rheum]). The mean age was 15.8 years (SD = 2.7), the majority were female (92%) and Caucasian (92%). Most (86%) had at least one psychiatric diagnosis, with anxiety (80%) the most common, followed by depression (42%). Many (42%) also reported poor sleep. Correlations were seen between the GAD-7, PROMIS pain and HRQoL. Worse anxiety and depression were correlated with more sleep problems. Depression, GAD-7, and ASWS were also correlated with worse HRQoL. Performing regression analyses found anxiety and pain to be most predictive of HRQoL. Psychiatric and sleep disorders are prevalent in pediatric patients with hEDS and impact HRQoL negatively. Clinical focus on the anxiety and pain are important due to their impact on HRQoL.
Journal Title
Rheumatology international
Volume
45
Issue
4
First Page
81
Last Page
81
MeSH Keywords
Humans; Quality of Life; Female; Ehlers-Danlos Syndrome; Male; Adolescent; Sleep Wake Disorders; Child; Prevalence; Longitudinal Studies; Anxiety; Depression; Patient Reported Outcome Measures; Mental Disorders
PubMed ID
40131551
Keywords
Ehlers Danlos syndrome; Mental health; Pediatrics; Psychiatric disorders; Sleep disorders
Recommended Citation
Hertel AK, Jones JT, Lytch A, Cramer E, Schroeder A, Black WR. Prevalence of psychiatric and sleep disorders and their impact on quality of life in children with hypermobile Ehlers-Danlos syndrome: an observational study. Rheumatol Int. 2025;45(4):81. Published 2025 Mar 25. doi:10.1007/s00296-025-05836-0
Comments
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Publisher's Link: https://link.springer.com/article/10.1007/s00296-025-05836-0