Development of a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders: Study protocol for the naltrexone neuroimaging randomized controlled trial (NN-RCT).
Document Type
Article
Publication Date
5-2025
Identifier
DOI: 10.1016/j.cct.2025.107874
Abstract
Eating disorders (ED) affect 5 % of youth, are associated with reward system alterations, and lead to substantial morbidity. Naltrexone, an opioid antagonist, is used to treat ED behaviors such as binge eating and purging. However, not all patients respond, and the optimal dose is unknown. Neuroimaging may serve as a tool to detect drug response in the brain, acting as a pharmacodynamic biomarker to support therapeutic optimization. Currently, no pharmacodynamic biomarkers for psychopharmacology exist. Building on pilot work, we present the protocol for a randomized controlled trial to validate neuroimaging as a pharmacodynamic biomarker of opioid antagonism in adolescents with ED. Youth aged 13-21 years with binge/purge ED are randomized to receive a single dose of oral naltrexone and placebo in a double-blind using a crossover design with an interdose interval ≥ 2 weeks. Task-based functional neuroimaging detects reward pathway modulation 2 h post-dose. Blood and urine are collected over a model-informed time course. Response (primary outcome) is defined as naltrexone-related blood oxygenation-level dependent signal change (Δ%BOLD) in a priori reward regions of interest and secondary exposure outcomes are naltrexone Cmax and AUC0-∞. Cohen's d will determine Δ%BOLD effect size, and an exposure-response model will identify target exposure to guide future dosing. This study addresses a critical knowledge gap by developing a non-invasive pharmacodynamic biomarker for youth with ED, with future applications in quantitative pharmacology, precision dosing, and the development of novel therapeutics.
Journal Title
Contemp Clin Trials
Volume
152
First Page
107874
Last Page
107874
MeSH Keywords
Adolescent; Female; Humans; Male; Young Adult; Biomarkers; Brain; Cross-Over Studies; Double-Blind Method; Feeding and Eating Disorders; Functional Neuroimaging; Magnetic Resonance Imaging; Naltrexone; Narcotic Antagonists; Neuroimaging; Randomized Controlled Trials as Topic; Reward
PubMed ID
40043750
Keywords
Adolescents; Eating disorders; Naltrexone; Opioid antagonism; Pharmacodynamic biomarker; fMRI
Recommended Citation
Stancil SL, Brewe ME, Tumberger J, et al. Development of a pharmacodynamic biomarker of opioid antagonism in adolescents with eating disorders: Study protocol for the naltrexone neuroimaging randomized controlled trial (NN-RCT). Contemp Clin Trials. 2025;152:107874. doi:10.1016/j.cct.2025.107874
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