Adenovirus Species in U.S. Children With Acute Respiratory Illness, 2016-2019.
Document Type
Article
Publication Date
6-16-2025
Identifier
DOI: 10.1093/jpids/piaf051
Abstract
BACKGROUND: Human adenovirus (HAdV) is a common cause of pediatric acute respiratory illness (ARI). HAdV-B, -C, and -E species have been associated with ARI, though relative detection frequencies in United States (U.S.) and respective roles in symptomatic respiratory infections remain unclear.
METHODS: We conducted a multicenter, prospective viral surveillance study at 7 U.S. children's hospitals comprising the New Vaccine Surveillance Network from January 12, 2016 to November 30, 2019. Children < 18 years old in the emergency department or hospitalized with fever and/or respiratory symptoms were enrolled, and respiratory specimens were tested for HAdV and other viral pathogens. HAdV-positive specimens were subsequently typed using single-plex real-time PCR assays targeting sequences in the hexon gene. Demographics, clinical characteristics, and outcomes (hospitalization and supplemental oxygen use as severity indicators) were compared between HAdV-B and HAdV-C species.
RESULTS: Of the 29 381 children with ARI, 1843 (6.3%) had HAdV detected, with 1402 specimens (76.0%) successfully typed. HAdV-C was the most frequently detected species (73.0%), followed by HAdV-B (22.3%). Children with HAdV-C were younger than those with HAdV-B and more likely to have another respiratory pathogen. Among children without other detected respiratory pathogens, those with HAdV-C had lower odds of hospitalization compared with children with HAdV-B (aOR: 0.44, 95% CI, 0.27-0.73, P =.001).
CONCLUSIONS: In our study among children seen in the emergency department or hospitalized with ARI, those with HAdV-C had lower odds of hospitalization compared with HAdV-B. These findings warrant further assessment to identify which HAdV types contribute to illness severity.
Journal Title
J Pediatric Infect Dis Soc
Volume
14
Issue
6
MeSH Keywords
Humans; Male; Female; Child, Preschool; Child; Respiratory Tract Infections; Adenoviruses, Human; Prospective Studies; Infant; Adenovirus Infections, Human; United States; Adolescent; Acute Disease; Hospitalization
PubMed ID
40448269
Keywords
adenovirus; epidemiology; pediatric; respiratory; species; types
Recommended Citation
Probst V, Stopczynski T, Amarin JZ, et al. Adenovirus Species in U.S. Children With Acute Respiratory Illness, 2016-2019. J Pediatric Infect Dis Soc. 2025;14(6):piaf051. doi:10.1093/jpids/piaf051
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Comments
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