Document Type
Article
Publication Date
9-2025
Identifier
DOI: 10.1017/S1047951125109293
Abstract
CHD has been historically associated with the development of cerebral abscess. This retrospective cohort study examines the association of CHD with the occurrence of cerebral abscess in an inpatient paediatric population. We analysed data from the Pediatric Health Information System database, an administrative database that captures data from participating children's hospitals in the United States. We included all patients admitted to participating paediatric ICUs between 2016 and 2021 for a total of 426,029 admissions. Including all admissions, 1,387 (0.3%) patients experienced a cerebral abscess, and of 80,927 (19%) patients with CHD, only 88 (0.1%) experienced a cerebral abscess (odds ratio 0.29, 0.23-0.36). Patients with seizures, cerebral oedema, stroke, shock, surgical intervention, and older age were associated with increased risk of development of a cerebral abscess. Interestingly, the development of a cerebral abscess was not associated with an increased risk of mortality (p = 0.937). When compared to patients without CHD admitted to the paediatric ICU, those with CHD appear less likely to develop a cerebral abscess. This study reiterates that cerebral abscess is a rare occurrence and does not demonstrate any significant association with CHD in a contemporary, inpatient population in the United States.
Journal Title
Cardiology in the young
Volume
35
Issue
9
First Page
1913
Last Page
1916
MeSH Keywords
Humans; Brain Abscess; Male; Female; Retrospective Studies; United States; Child, Preschool; Databases, Factual; Infant; Child; Heart Defects, Congenital; Risk Factors; Adolescent; Infant, Newborn; Incidence; Intensive Care Units, Pediatric
PubMed ID
40977285
Keywords
CHD; Cerebral abscess; cyanotic heart disease
Recommended Citation
Ewing K, Loomba RS, Flores S, Villarreal EG, Farias JS, Coghill MT. Association between CHD and cerebral abscess: insights from a national database. Cardiol Young. 2025;35(9):1913-1916. doi:10.1017/S1047951125109293
Comments
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
Publisher's Link: https://www.cambridge.org/core/journals/cardiology-in-the-young/article/association-between-chd-and-cerebral-abscess-insights-from-a-national-database/409D43210F787336FFBBE9AD32F32821