Severe Immune Thrombocytopenia and Myositis After 23-Valent Pneumococcal Vaccine.
Document Type
Article
Publication Date
1-2026
Identifier
DOI: 10.1016/j.pedhc.2025.07.003
Abstract
An adolescent patient developed a severe local inflammatory reaction, acute kidney injury, extensive myofascitis, and profound immune thrombocytopenia resulting in vitreous hemorrhage and long-term permanent visual impairment after 23-valent polysaccharide pneumococcal vaccine administration. This severe adverse outcome has not previously been reported in the literature with this particular vaccination. This case highlights rare but serious potential adverse immunologic effects of polysaccharide vaccines.
Journal Title
Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
Volume
40
Issue
1
First Page
142
Last Page
146
MeSH Keywords
Adolescent; Humans; Myositis; Pneumococcal Infections; Pneumococcal Vaccines; Purpura, Thrombocytopenic, Idiopathic
PubMed ID
40801863
Keywords
adverse effect; myositis; pneumococcal; thrombocytopenia; vaccine
Recommended Citation
Gampala A, Minnaganti D, Weidemann D. Severe Immune Thrombocytopenia and Myositis After 23-Valent Pneumococcal Vaccine. J Pediatr Health Care. 2026;40(1):142-146. doi:10.1016/j.pedhc.2025.07.003
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