Document Type
Article
Publication Date
1-2026
Identifier
DOI: 10.1007/s10856-025-06990-4; PMCID: PMC12783310
Abstract
Orthopedic osteosarcomas and metastatic lesions can be difficult to treat with systemically delivered chemotherapy agents alone. Following removal of the primary tumor, implantation of cement to fill the lesion is often done to stabilize weight-bearing bones. One of the commonly used treatments to address osteosarcoma is systemic delivery of doxorubicin. Therefore, research on the incorporation and release of efficacious doxorubicin for local delivery from cement is important. Poly(methyl methacrylate) (PMMA)-based bone cements are the gold standard in orthopedics but have inherent disadvantages. Efforts to overcome some of these deficiencies led to the development of a novel silorane-based biomaterial (SBB). This work evaluated the ability of both PMMA and SBB to incorporate and release efficacious doxorubicin. PMMA-released doxorubicin showed reduced chemotherapeutic efficacy in vitro. The mechanical properties of PMMA were reduced from controls upon doxorubicin incorporation, likely stemming from doxorubicin inhibition of PMMA radical polymerization. SBB properties were not affected by doxorubicin incorporation and SBB eluted doxorubicin was fully efficacious in vitro compared to doxorubicin controls. These results indicate a likely inhibitory interaction between PMMA and doxorubicin, which affects both the strength of PMMA and the efficacy of doxorubicin. Further, this work illustrates SBB as a potential biomaterial alternative for traditional acrylics for medical biomaterial applications where load-bearing strength alongside drug delivery are key factors.
Journal Title
Journal of materials science. Materials in medicine
Volume
37
Issue
1
First Page
13
Last Page
13
MeSH Keywords
Doxorubicin; Polymethyl Methacrylate; Bone Cements; Drug Carriers; Humans; Materials Testing; Drug Delivery Systems; Biocompatible Materials; Osteosarcoma; Bone Neoplasms; Antibiotics, Antineoplastic
PubMed ID
41452478
Keywords
Doxorubicin; Polymethyl Methacrylate; Bone Cements; Drug Carriers; Humans; Materials Testing; Drug Delivery Systems; Biocompatible Materials; Osteosarcoma; Bone Neoplasms; Antineoplastic Antibiotics
Recommended Citation
Funk, G.A., Menuey, E.M., Denton, Z.D. et al. A comparison of poly(methyl methacrylate) and silorane-based cements as carriers for local doxorubicin delivery. J Mater Sci: Mater Med 37, 13 (2026). https://doi.org/10.1007/s10856-025-06990-4
Comments
Grants and funding
This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.
Publisher's Link: https://link.springer.com/article/10.1007/s10856-025-06990-4