Changes in Suicidality among Transgender Adolescents Following Hormone Therapy: An Extended Study.
Document Type
Article
Publication Date
2-2026
Identifier
DOI: 10.1016/j.jpeds.2025.114883
Abstract
OBJECTIVE: To examine changes in suicidality following hormone therapy (HT) among transgender and gender-diverse adolescents and young adults.
STUDY DESIGN: A retrospective chart review was conducted at a multidisciplinary gender health clinic with 432 patients (mean follow-up = 679 days) completing the Ask Suicide-Screening Questions before and after treatment initiation. A repeated-measures ANCOVA assessed within-person changes in suicidality over time, adjusting for age at treatment and treatment duration.
RESULTS: Suicidality significantly declined from pretreatment to post-treatment (F[1, 426] = 34.63, P < .001, partial η2 = 0.075). This effect was consistent across sex assigned at birth, age at start of therapy, and treatment duration.
CONCLUSIONS: HT was associated with clinically meaningful reductions in suicidality over time, extending prior findings with a larger sample and longer follow-up. These study findings provide clinical evidence supporting the mental health benefits of timely access to HT in this population.
Journal Title
The Journal of pediatrics
Volume
289
First Page
114883
Last Page
114883
MeSH Keywords
Humans; Adolescent; Retrospective Studies; Male; Female; Transgender Persons; Young Adult; Suicidal Ideation; Suicide; Hormone Replacement Therapy; Follow-Up Studies
PubMed ID
41177392
Keywords
adolescent; estrogen; gender dysphoria; gender-affirming hormones; testosterone; transgender; youth
Recommended Citation
Allen LR, Dodd CG, Moser CN, Knoll MM. Changes in Suicidality among Transgender Adolescents Following Hormone Therapy: An Extended Study. J Pediatr. 2026;289:114883. doi:10.1016/j.jpeds.2025.114883
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