Factors associated with liberation from home mechanical ventilation and tracheostomy decannulation in infants and children with severe bronchopulmonary dysplasia.
Document Type
Article
Publication Date
2-2026
Identifier
DOI: 10.1038/s41372-024-02078-z
Abstract
OBJECTIVE: To identify factors associated with the timing of ventilator liberation and tracheostomy decannulation among infants with severe bronchopulmonary dysplasia (sBPD) who required chronic outpatient invasive ventilation.
STUDY DESIGN: Multicenter retrospective study of 154 infants with sBPD on outpatient ventilators. Factors associated with ventilator liberation and decannulation were identified using Cox regression models and multilevel survival models.
RESULTS: Ventilation liberation and decannulation occurred at median ages of 27 and 49 months, respectively. Older age at transition to a portable ventilator and at discharge, higher positive end expiratory pressure, and multiple respiratory readmissions were associated with delayed ventilator liberation. Surgical management of gastroesophageal reflux was associated with later decannulation.
CONCLUSIONS: Ventilator liberation timing was impacted by longer initial admissions and higher ventilator pressure support needs, whereas decannulation timing was associated with more aggressive reflux management. Variation in the timing of events was primarily due to individual-level factors, rather than center-level factors.
Journal Title
Journal of perinatology : official journal of the California Perinatal Association
Volume
46
Issue
2
First Page
175
Last Page
181
MeSH Keywords
Humans; Bronchopulmonary Dysplasia; Retrospective Studies; Tracheostomy; Infant; Male; Female; Child, Preschool; Respiration, Artificial; Ventilator Weaning; Infant, Newborn; Proportional Hazards Models; Gastroesophageal Reflux; Time Factors; Home Care Services; Tracheostomy Decannulation
PubMed ID
39085436
Keywords
Bronchopulmonary Dysplasia; Retrospective Studies; Tracheostomy; Artificial Respiration; Ventilator Weaning; Proportional Hazards Models; Gastroesophageal Reflux; Time Factors; Home Care Services; Tracheostomy Decannulation
Recommended Citation
Agarwal A, Manimtim WM, Alexiou S, et al. Factors associated with liberation from home mechanical ventilation and tracheostomy decannulation in infants and children with severe bronchopulmonary dysplasia. J Perinatol. 2026;46(2):175-181. doi:10.1038/s41372-024-02078-z
COinS
Comments
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