Document Type

Article

Publication Date

4-17-2026

Identifier

DOI: 10.31083/FBL47779

Abstract

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized by relapsing and remitting disease activity. Despite decades of research, a definitive cure for IBD remains elusive, as cycles of remission and flare-ups mark the disease course and often relies on long-term pharmacologic and supportive strategies. Increasing evidence indicates that diet and nutrition play an important role in modulating the outcomes of IBD. Although a wide range of dietary interventions has been explored, no universally effective approach has been established. Investigations have also proven that different dietary interventions can significantly affect clinical outcomes by altering gut microbial composition. This review explores a novel approach to IBD management by integrating gut microbiome modulation into personalized patient diets. The review examines various dietary interventions commonly used in IBD treatment and their impact on the gut microbiome composition. Furthermore, the study proposes a framework for creating personalized nutrition based on individual microbiome profiles. Finally, the review discusses the potential of personalized nutrition as a long-term therapeutic strategy for IBD management, offering insights into its feasibility and implications for patient care.

Journal Title

Front Biosci (Landmark Ed)

Volume

31

Issue

4

First Page

47779

Last Page

47779

MeSH Keywords

Humans; Gastrointestinal Microbiome; Inflammatory Bowel Diseases; Precision Medicine; Diet

PubMed ID

42052843

Keywords

diet; gut microbiome; inflammatory bowel disease

Comments

This is an open access article under the CC BY 4.0 license.

Publisher's Link: https://www.imrpress.com/journal/FBL/31/4/10.31083/FBL47779

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