Document Type

Article

Publication Date

4-2026

Identifier

DOI: 10.1093/jamiaopen/ooag057; PMCID: PMC13291905

Abstract

PURPOSE: The MTXPK.org webtool facilitates model-informed supportive care and glucarpidase use in patients receiving high-dose methotrexate, but its reliance on manual data entry limits workflow integration. We aimed to highlight how translational informatics can advance, automate, and enhance the usability of clinical decision support tools by embedding MTXPK.org within the electronic health record (EHR).

METHODS: A human factors study with 6 clinical providers guided iterative prototype development. MTXPK.org was rebuilt within the EHR using a 3-tier architecture with Fast Healthcare Interoperability Resources-based data retrieval, automated pharmacokinetic modeling, and interactive visualization.

RESULTS: Two rounds of prototyping with task-based evaluations and contextual inquiry showed progressive improvements in information recognition and navigation. The final design achieved excellent usability, with a System Usability Scale score of 90.4 compared to 57 for the original MTXPK.org tool. The dashboard is now live, automating data entry and generating individualized pharmacokinetic profiles with interactive visualization.

CONCLUSIONS: The Methotrexate Monitoring Tool is an integrated methotrexate dashboard that automates data entry, improves usability, and facilitates model-informed supportive care and glucarpidase use.

Journal Title

JAMIA Open

Volume

9

Issue

2

First Page

057

Last Page

057

PubMed ID

42358613

Keywords

Clinical decision support; methotrexate; oncology; pediatrics; precision medicine

Comments

This is an open access article distributed under the terms of the Creative Commons CC BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Publisher's Link: https://academic.oup.com/jamiaopen/article-lookup/doi/10.1093/jamiaopen/ooag057

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