Rotavirus Vaccine Coverage and Potential Barriers Among US Children Born From 2007 to 2024.

Document Type

Article

Publication Date

7-1-2026

Identifier

DOI: 10.1542/peds.2025-074382

Abstract

BACKGROUND/OBJECTIVES: The Advisory Committee on Immunization Practices recommends the first dose of rotavirus vaccine (RVV) be delivered by a maximum age of 14 weeks, 6 days and that the vaccine not be delivered until time of discharge from the neonatal intensive care unit (NICU). We hypothesized that these guidelines limit the number of children who can be vaccinated with RVV.

METHODS: Children born on or after January 1, 2007, enrolled in the New Vaccine Surveillance Network from December 2014 to August 2024 aged at least 15 weeks with rotavirus-negative acute gastroenteritis or as a healthy control, and with known vaccination status were included. We identified factors associated with not initiating or completing the RVV series and missed opportunities for vaccination. Odds ratios (ORs) and 95% CIs were calculated using univariate logistic regression.

RESULTS: A total of 24 755 children met the inclusion criteria. The risk factors most strongly associated with not initiating RVV were receiving the diphtheria, tetanus, and pertussis vaccine at greater than or equal to age 15 weeks (OR, 30.0; 95% CI, 26.8-33.7), extremely preterm birth (OR, 14.6; 95% CI, 11.2-20.0), being born soon after RVV introduction (2007-2009) (OR, 3.3; 95% CI, 2.9-3.8), and having no health insurance (OR, 2.2; 95% CI, 1.8-2.7). More than 50% of extremely preterm infants in the NICU were not discharged until greater than or equal to age 15 weeks.

CONCLUSIONS: Re-evaluation of the vaccine guidelines to allow RVV administration in the NICU may remove barriers to vaccination and help improve RVV coverage.

Journal Title

Pediatrics

Volume

158

Issue

1

MeSH Keywords

Humans; Rotavirus Vaccines; United States; Female; Rotavirus Infections; Infant, Newborn; Male; Vaccination Coverage; Infant; Gastroenteritis; Unvaccinated Persons

PubMed ID

42252117

Keywords

Rotavirus Vaccines; United States; Rotavirus Infections; Vaccination Coverage; Gastroenteritis; Unvaccinated Persons

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