Document Type
Response or Comment
Publication Date
7-8-2026
Identifier
DOI: 10.1016/j.xgen.2026.101301; PMCID: PMC13347937
Abstract
Large differences in gene dosage are usually associated with opposite phenotypic effects but show a bias toward one direction in aggregate genome wide. Milind et al. suggest that this is explained by differences in regulatory mechanisms by which genes influence phenotypes and by the increased selective pressures acting on a subset of genes.
Journal Title
Cell Genom
Volume
6
Issue
7
First Page
101301
Last Page
101301
MeSH Keywords
Gene Dosage; Phenotype; Humans; Animals
PubMed ID
42419259
Keywords
Gene Dosage; Phenotype
Recommended Citation
Smail C. Gene dosage differences and non-linear impacts on complex traits. Cell Genom. 2026;6(7):101301. doi:10.1016/j.xgen.2026.101301
COinS
Comments
Comment on
Buffering of gene dosage response curves for human complex traits
Milind et al.
Cell Genomics May 7, 2026 This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/). Publisher's Link: https://doi.org/10.1016/j.xgen.2026.101301