The relationship of eosinophilia with outcomes of Hirschsprung disease in children.

Creator(s)

Richard Sola
Ashwini S. Poola
Rmaah Memon
Vivekanand Singh, Children's Mercy HospitalFollow
Richard J. Hendrickson, Children's Mercy HospitalFollow
Shawn D. St Peter, Children's Mercy HospitalFollow
Jason D. Fraser, Children's Mercy HospitalFollow

Document Type

Article

Publication Date

4-1-2019

Identifier

DOI: 10.1007/s00383-018-04430-9

Abstract

PURPOSE: It has been postulated that children with Hirschsprung disease (HD) and mucosal eosinophilia have been thought to have poorer outcome, but supporting evidence is lacking. The objective of our study was to review the outcomes of children with HD and mucosal eosinophilia.

METHODS: A single center, retrospective review was conducted on all patients diagnosed with HD between 1999 and 2016. Pathology specimens were evaluated for mucosal eosinophilia. Demographics, complications, and outcomes were analyzed.

RESULTS: A total of 100 patients were diagnosed with HD and 27 had mucosal eosinophilia. Median age at the time of surgery was 12 days (8, 30) and 82 were males. Comparing patients with HD with and without mucosal eosinophilia, there was no statistically significant difference in time to bowel function (2 days vs. 2 days; p = 0.85), time to start feeds (3 days vs. 3 days; p = 0.78) and time to goal feeds (5 days vs. 5 days; p = 0.47). There was no statistically significant difference in feeding issues (13% vs. 9%; p = 1.0) and stooling issues (60% vs. 50%; p = 0.38). There was no statistically significant difference in postoperative complications and readmissions rates (63% vs. 56%; p = 0.53).

CONCLUSION: Hirschsprung-associated mucosal eosinophilia may not increase postoperative complications, and may not change feeding and bowel management. Further prospective studies are in process to evaluate long term follow-up outcomes for this patient population.

Journal Title

Pediatric surgery international

Volume

35

Issue

4

First Page

425

Last Page

429

MeSH Keywords

Biopsy; Digestive System Surgical Procedures; Eosinophilia; Female; Hirschsprung Disease; Humans; Incidence; Infant, Newborn; Intestinal Mucosa; Male; Postoperative Complications; Rectum; Retrospective Studies; Treatment Outcome; United States

Keywords

Children; Eosinophilia; Hirschsprung disease

Recommended Citation

Sola R Jr, Poola AS, Memon R, et al. The relationship of eosinophilia with outcomes of Hirschsprung disease in children. Pediatr Surg Int. 2019;35(4):425-429. doi:10.1007/s00383-018-04430-9