Publication Date




Download Full Text (126 KB)


We describe a case of an adolescent female with Type A insulin resistance whose severe hirsutism and hyperandrogenism were improved with leuprolide, despite extreme hyperinsulinemia. Ovarian volume decreased in association with the resolution of hyperandrogenism, consistent with ovarian size reflecting hyperandrogenism in adolescents.

This case allowed us to examine the frequently debated bidirectional relationship between insulin and hyperandrogenism, often deemed independent of gonadotropin activity.

MeSH Keywords

Insulin Resistance; Hyperandrogenism; Leuprolide; Receptor, Insulin/genetics; Adolescent; Female; Polycystic Ovary Syndrome


GnRH agonist; PCOS


Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Pediatrics


Presented at Children's Mercy Research Days, May 2019

Gonadotropin Releasing Hormone (GnRH) Agonist Improves Hyperandrogenism in an Adolescent Female with a Novel Insulin Receptor Gene Mutation



To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.