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We describe a case of an adolescent female with Type A insulin resistance whose severe hirsutism and hyperandrogenism were improved with leuprolide, despite extreme hyperinsulinemia. Ovarian volume decreased in association with the resolution of hyperandrogenism, consistent with ovarian size reflecting hyperandrogenism in adolescents.
This case allowed us to examine the frequently debated bidirectional relationship between insulin and hyperandrogenism, often deemed independent of gonadotropin activity.
Insulin Resistance; Hyperandrogenism; Leuprolide; Receptor, Insulin/genetics; Adolescent; Female; Polycystic Ovary Syndrome
GnRH agonist; PCOS
Endocrine System Diseases | Endocrinology, Diabetes, and Metabolism | Pediatrics
Paprocki, Emily; Barral, Romina; Vanden Brink, Heidi; Lujan, Maria E.; and Burgert, Tania S., "Gonadotropin Releasing Hormone (GnRH) Agonist Improves Hyperandrogenism in an Adolescent Female with a Novel Insulin Receptor Gene Mutation" (2019). Posters. 102.