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Acute bilirubin encephalopathy (ABE) and kernicterus spectrum disorder (KSD) have become relatively uncommon in high income countries but remain a major cause of morbidity and mortality in low- and middle-income countries. To better understand the relationship between free (Bf) and total (TB) bilirubin levels and the development of ABE and KSD we followed infants born in three large tertiary centers in northern and central Nigeria (Jos, Kano and Zaria).

MeSH Keywords

Bilirubin/blood; Kernicterus; Nigeria; Hyperbilirubinemia, Neonatal; Hemolysis


bilirubin encephalopathy; kernicterus spectrum disorder


Congenital, Hereditary, and Neonatal Diseases and Abnormalities | International Public Health | Neurology | Pediatrics


Presented at the Pediatric Academic Societies Meeting in Baltimore, Maryland on April 27, 2019.

Total and Free Plasma Bilirubin and Clinical Outcomes in Severe Hyperbilirubinemia



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