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  Mutant p53 Depletion by Natural Compounds

  Mohamed A.A. Alalem, Sana Farooki, and Tomoo Iwakuma

  The goal of this research project is to identify and characterize potentially novel antineoplastic agents that could specifically degrade conformational mutP53 protein in cancer cells. We concluded that treatment of cancer cells with curcumin or PLINH compounds inhibit proliferation of cancer cells in a DNAJA1-misfolded mutp5-dependent manner. Delineation of the exact mechanism through which curcumin and PLINH exert their anti-cancer effects could pave the way for promising novel preventive and therapeutic modalities for cancer.

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  The Physiology and Hormonal Control of Calcium, Phosphate and Vitamin D

  Uri Alon

  Describes calcium, phophate, and vitamin D in the context of pediatric rickets.

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  Comparison of Post-Operative Pain Control Modalities for Pectus Excavatum Repair

  Charlene Dekonenko

  This study compares patient outcomes following pectus excavatum repair using cryoablation, epidural, or patient-controlled analgesia for post-operative pain control. Primary outcome: length of stay
  Secondary outcomes: operative time, pain scores, time to only oral analgesics.
  Conclusion: Intercostal cryoablation during minimally invasive pectus excavatum repair significantly reduces length of stay and time to oral analgesics alone.

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  Early Identification of Depression in Patients with Pediatric Epilepsy

  Erin Day Fecske

  Describes a program to assess adolescent patients with epilepsy for depression, and to refer these patients to mental health services when appropriate.

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  "Making Learning and Teaching Fun Again!" - Strategies to Improve Learner Engagement and Retention

  Kadriye O. Lewis, Jennifer Colombo, Christian Lawrence, Kenya McNeal-Trice, and Mark Chandler

  This presentation describes and demonstrates different strategies for medical education.

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  The Effect of Antihypertensive Dose on Blood Pressure Control in Children with Chronic Kidney Disease

  Benjamin A. Matta

  This presentation describes a study to determine the effect of antihypertensive dosing on blood pressure control in children with chronic kidney disease. The original version of this presentation is a prezi show at https://prezi.com/view/4qluDL1gMKFELOf1nLVA/

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  Improved Coordination of Care for PICU Patients with Newly Diagnosed Anterior Mediastinal Masses

  Laura McCarthy

  This presentation describes a quality improvement project to develop a multi-disciplinary standardized approach for prompt surgical intervention to establish a diagnosis of anterior mediastinal mass. The aim was to decrease the time from presentation to surgical diagnostic procedure to <24 hours for all patients with newly diagnosed AM masses. An Anterior Mediastinal Mass Recommended Pathway was developed to improve communication and reduce time to diagnosis and>treatment.

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  Decreasing Unplanned Extubations by Taping Technique & Creating a Culture of Safety

  Karishma Rao, Beckie Palmer, Christopher R. Nitkin, Christian Anthony Schneider, Brandy Huitt, Molly Terhune, Ashley Orwick, Dianne Wilderson, Sarah Carboneau, Jenny McKee, Kerrie A. Meinert, and Eugenia K. Pallotto

  Describes strategies used to decrease the unplanned extubation rate in the Level IV neonatal intensive care unit to less than 1.0 event per 100 ventilator days by December 2018.

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  Impact of a Mobile Device-Based Clinical Decision Support Tool on Guideline Adherence and Mental Workload Among Trainee and Attending Physicians

  Katherine M. Richardson

  This study evaluated PedsGuide, an app used to evaluate serious bacterial infections in febrile infants.

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  21st Century Clinical Trials: Rethinking Best Practices Challenges and Opportunities

  William E Truog

  Panel discussion at the Pediatric Academic Societies 2019 annual meeting.

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  Alternative Care Models for Management of Diabetes

  Sarah Tsai

  Describes effort to improve A1C in teens using motivational interviewing vs. traditional patient/provider interaction in real-world clinic setting.

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  Human Trafficking and Today's Youth

  Rachel Whitfield

  This presentation is designed to help health care providers

  • Dispel myths around US domestic trafficking
  • Define the different types of human trafficking
  • Understand the contributing factors for trafficking
  • Understand the effect of pornography on the developing brain
  • Recognize risk factors and signs and symptoms of trafficking
  • Know how to report human trafficking and where to find local resources

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  ICN Flu Vaccine Cocooning

  Allison Bauer BSN, RN; Brittany Wolter BSN, RN; Jonathan Rind BSN, RN; Maggie Butaud BSN, RN; Sarah Dumovich BSN,RN; Tori Weishaar BSN, RN; and Karli Wittenbach BSN, RN

  PICO Question

  P (Population): Registered nurses in the CMH Intensive Care Nursery providing patient care.

  I (Intervention): Electronic documentation of parent flu vaccine status. Include vaccine status reminder in pod huddle.

  C (Comparison): Current practice

  O (Outcome): Increase the percentage of families receiving the flu-vac

  Aim Statement

  The objective of this evidence based practice project is to increase the percentage of families receiving the flu vaccine from 83% to 85% by March of 2018

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  Safe Baby

  Hannah Burger BSN, RN; Samantha Cockrell BSN, RN; Shauni Lawrence BSN, RN; Shae McGinnis BSN, RN; Christina Montgomery RN; and Elizabeth Taylor RN

  PICO Question

  P: 4 Henson and 5 Sutherland patients who qualify for Safe Sleep Practices according to the Safe Sleep Policy.
  I: Creating a useable checklist to be completed with each infant and each shift change
  C: Current standard of care
  O: Increased compliance with safe to sleep practices

  Aim Statement

  The objective of this evidence based practice project is to increase Safe Sleep compliance from 50% to 65% on 4 Henson and 5 Sutherland by February 1, 2018.

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  PICU Patient Satisfaction

  Kaitlyn Enochs BSN, RN; Jonathan Foley BSN, RN; Tara Goodman BSN, RN; Abby Haupt BSN, RN; Chelsea Koerkenmeier BSN, RN; Allison Mills BSN, RN; Kara Mishler BSN, RN; Madison Myers BSN, RN; Michelle Noykhovich BSN, RN; Sophia Poplin BSN,RN; Austin Reyes BSN, RN; Kylie Stottlemyre BSN, RN; Sarah Swift BSN, RN; Danielle Warner BSN, RN; Emily Zimmerman BSN, RN; Brooke English MSN, RN, CCRN; and Katherine Hoffman BSN, RN

  PICO

  PICU secretaries and parents will be able to increase the number of completed parent satisfaction surveys compared to current actions and supports.

  Aim Statement

  • To increase rate of completed parent survey by 5%, as measured by the number of surveys submitted each quarter by January 2018
  • To have 10% response rate to surveys for patients that have been in the PICU for 30 days or greater.

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  Chasing Never: Unplanned Extubation

  LeeAnna Gaspers BSN,RN; Brittney Gerber BSN,RN; Madison Hersma BSN,RN; Erin Keith-Chancy BSN,CCRN; Audrey Knodell BSN,RN; Jordan Miller BSN,RN; Liz Morrow BSN,RN; Tara Otterson BSN,RNC; Chantal Rogers BSN,RN; and Abby Slaven BSN,RN

  PICO Question

  • P:In the Intubated neonate
  • I: can the bundling of potentially best practice recommendations (tube location documentation, 2-person handling, and management of positioning and secretions) and standardized hourly assessment with documentation of compliance
  • C: current standard of practice
  • O: decreased unplanned extubations

  Aim Statement

  Decrease the rate of unplanned extubations in the ICN from 1.38/100 ventilator days in 2016 to 1 event/100 ventilator days in 2017.

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  ABCs of Safe Sleep

  Alyson Hill RN, Jennifer Markey RN, Bailey Ritter RN, Ashley Smith RN, and Aaron Smithson RN

  PICO Question

  Does education and teaching to parents and family regarding safe sleep practices increase the compliance of safe sleep for infants 0-12 months on 4 Sutherland compared to the current practice?

  Aim Statement

  The objective of the evidence based practice project is to increase Safe Sleep compliance by improving education given to parents and family from 20% to 90% by February 2018

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  Baby Got BAC

  Tina Histand BSN, RN; Heidi Mustapich BSN, RN; Brittany Parks RN; Mallory Potter BSN, RN; and Melanie Traynham RN

  PICO Statement

  • Population: 6 Henson patients who qualify for Safe Sleep Practices according to the Safe Sleep Policy.
  • Intervention: Signs will placed in high patient care areas to provide awareness and reminders to 6 Henson patient caregivers of correct safe sleep practices.
  • Comparison: Current standard of care
  • Outcomes: Increased compliance with safe to sleep practices

  Aim Statement

  The objective of this evidence based practice project is to increase Safe Sleep compliance on the 6 Henson unit by 10% by March of 2018

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  Save the Pharmacy Piggy Bank: Managing Mega High-Cost Drugs

  Richard K. Ogden Jr., Jerame Hill, and Sam Abdelghany

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  Same Day Discharge for Non-Perforated Appendicitis in Children: An Updated Institutional Protocol

  Tolulope A. Oyetunji MD MPH

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  ED Staff Morale

  Madison Wilkins RN, Tonya Cross RN, Brittany Schmalzbach RN, Noah Olla RN, Fred Richards RN, and Emily Pendleton RN

  PICO Question

  PICO Question & Aim Statement

  • (Population, Intervention, Comparison, Outcomes Measures)

  • P: ED Nurses and Support Staff

  • I: Huddle Recognition and prizes

  • C: No recognition

  • O: Improved nursing morale

   To increase the median morale of nursing and support staff from 74% to 80% as measured by Daily Pulse by March of 2018

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  Evaluating the Consistency and Quality of Search Strategies and Methodology in Cochrane Urology Group Systematic Reviews

  Jennifer A. Lyon, Carrie Price, Jamie Saragossi, and Clara Y. Tran

  OBJECTIVES

  The Cochrane Urology Working Group has undergone multiple administrative and personnel changes over its history. Presently, there are nearly a dozen Information Specialists volunteering from several institutions and two countries. To identify areas for quality and consistency improvement, we evaluated the search methodologies in 64 Urology Group Reviews/Protocols.

  METHODS

  64 published Urology Group Cochrane Systematic Reviews (CSR) and Protocols (CSP) were downloaded from the Cochrane Library on September 15, 2016. A data form was created using Qualtrics consisting of several sections including expanded PRESS (Peer-Review of Electronic Search Strategies) elements, database selection, search methodology reporting, & consistency. Four librarians, including two Cochrane Urology Assistant Information Specialists, evaluated 20 CSR/Ps each, allowing overlap to verify data extraction reliability.

  RESULTS

  Librarian reviewers noted high variability in CSR/P search methods including selection of databases searched, full search strategies reporting, and use of publication filters, clinical trial registries, conference proceedings, and journal TOCs. Within search strategies, common errors included wrong line numbers, misspellings, inappropriate syntax, and duplicated lines.

  CONCLUSIONS

  Cochrane Reviews are frequently viewed as the "gold standard" of systematic reviews, therefore the CSR/Ps should have high quality search methodology. This retrospective analysis represents a historical overview of search method reporting in CSR/Ps from the Cochrane Urology Group. Our results demonstrate a need for improved standardization including complete documentation of all strategies, more consistent database selection, less variation in strategy construction, increased use of peer-review and inclusion of the PRISMA Flow Diagram, and tighter adherence to the Cochrane Handbook/MECIR Standards.