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Introduction: 22q11.2 deletion syndrome (22q11DS) and 22q duplication syndrome present a wide range of medical challenges. The health and well-being of pediatric patients with 22q11DS may be influenced by socioeconomic factors, which can significantly shape their healthcare experiences, access to services, and overall quality of life. The objective of this study is to identify what factors are correlated with no-show clinic visits for children with 22q11DS.

Methods: A retrospective chart review was performed on pediatric patients in a 22q patient registry of a tertiary care facility that includes patients with 22q11DS and 22q duplication syndrome. Demographic data, sex assigned at birth, appointment attendance, comorbid conditions, and patient specific outcomes were collected for analysis. The patient’s home address was cross-referenced with the GeoMarker database to define corresponding specific socioeconomic contextual variables.

Results: 236 patients were included in the study including 198 patients (83.9%) with 22q11DS and 38 patients (16.1%) with 22q duplication syndrome. Collectively, these patients were scheduled for a total of 9,734 clinic visits and 2,347 visits with the 22q multidisciplinary clinic. The overall mean rate of no-show clinic visits was 7.69% ± 10.90. Factors associated with clinic no-show included lower median household income (OR (95% CI) 1.43 (1.25-1.64), p < .001), lower fraction of population with high school diploma (OR (95% CI) 2.33 2.04-2.67), higher fraction of population below the poverty line (OR (95% CI) 1.52 (1.32-1.73), p < .001) and higher fraction of population that required assisted income (OR (95% CI) 1.38 (1.21-1.58), p < .001). Interestingly, farther distance from the tertiary care facility was associated with lower no-show rate (OR (95% CI) 0.71 (0.60-0.85), p < .001).

Conclusion: These findings highlight the potential influence of socioeconomic factors on no-show clinic appointments in pediatric patients with 22q11DS. These factors can be used to help identify patients at risk of no-show clinic appointments and be used to develop targeted interventions aimed at improving clinic attendance and ultimately elevating patient outcomes.

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No-Show Clinic Appointments and the Social Determinants of Health in Pediatric Patients with 22q