Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation.

Creator(s)

Laura A. Wang
Daniel Gonzalez
J Steven Leeder, Children's Mercy HospitalFollow
Rachel F. Tyndale
Robin E. Pearce, Children's Mercy HospitalFollow
Daniel K. Benjamin
Gregory L. Kearns
Michael Cohen-Wolkowiez
Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee

Document Type

Article

Publication Date

2-1-2017

Identifier

PMCID: PMC5233579 DOI: 10.1002/jcph.797

Journal Title

Journal of clinical pharmacology

Volume

57

Issue

2

First Page

230

Last Page

234

MeSH Keywords

Anti-Infective Agents; Cohort Studies; Cytochrome P-450 Enzyme System; Female; Genetic Variation; Humans; Infant, Newborn; Male; Metronidazole

Keywords

metabolism; metronidazole; neonates; pharmacokinetics

Comments

Grant support

• K24 HD058735/HD/NICHD NIH HHS/United States

• HHSN272201300017C/AI/NIAID NIH HHS/United States

• HHSN272201300017I/AI/NIAID NIH HHS/United States

• K23 HD083465/HD/NICHD NIH HHS/United States

• R03 MH109787/MH/NIMH NIH HHS/United States

• U01 FD004858/FD/FDA HHS/United States

• HHSN275201000003C/HD/NICHD NIH HHS/United States

• TMH109787/CIHR/Canada

• HHSN275201000003I/HD/NICHD NIH HHS/United States

• UL1 TR001117/TR/NCATS NIH HHS/United States

• HHSN272201500006C/AI/NIAID NIH HHS/United States

• R01 HD076676/HD/NICHD NIH HHS/United States

Recommended Citation

Wang LA, Gonzalez D, Leeder JS, et al. Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation. J Clin Pharmacol. 2017;57(2):230-234. doi:10.1002/jcph.797