Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy.

Document Type

Article

Publication Date

5-2020

Identifier

DOI: 10.1097/PHM.0000000000001334

Abstract

The aim of the study was to identify oral baclofen dosing variability at steady state based on weight and Gross Motor Function Classification System level using a retrospective cross-sectional study design. The medical records of 500 pediatric aged patients (age 1-21 yrs) were reviewed to obtain 144 pediatric patients who met inclusion criteria. One-way analysis of variance tests revealed increasing mean doses in baclofen (in milligram per kilogram) with higher Gross Motor Function Classification System levels (P = 0.001). Post hoc Tukey analysis showed patients with higher ambulatory ability (Gross Motor Function Classification System I-II) received a lower total daily dosage than did patients with less ambulatory ability (Gross Motor Function Classification System III-V). A moderate correlation was observed with increasing oral baclofen dose as weight increased (r = 0.43, P < 0.0001). Because of the variability in dosing between Gross Motor Function Classification System levels, prescribing oral baclofen for pediatric patients with cerebral palsy may not follow the traditional model of weight-based dosing seen in other pediatric conditions.

Journal Title

American journal of physical medicine & rehabilitation / Association of Academic Physiatrists

Volume

99

Issue

5

First Page

441

Last Page

443

MeSH Keywords

Administration, Oral; Adolescent; Baclofen; Body Weight; Cerebral Palsy; Child; Child, Preschool; Cross-Sectional Studies; Disability Evaluation; Female; Humans; Infant; Male; Muscle Relaxants, Central; Practice Patterns, Physicians'; Retrospective Studies; Young Adult

Keywords

Adolescent; Baclofen; Body Weight; Cerebral Palsy; Disability Evaluation; Muscle Relaxants

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