Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy.
The aim of the study was to identify oral baclofen dosing variability at steady state based on weight and Gross Motor Function Classification System level using a retrospective cross-sectional study design. The medical records of 500 pediatric aged patients (age 1-21 yrs) were reviewed to obtain 144 pediatric patients who met inclusion criteria. One-way analysis of variance tests revealed increasing mean doses in baclofen (in milligram per kilogram) with higher Gross Motor Function Classification System levels (P = 0.001). Post hoc Tukey analysis showed patients with higher ambulatory ability (Gross Motor Function Classification System I-II) received a lower total daily dosage than did patients with less ambulatory ability (Gross Motor Function Classification System III-V). A moderate correlation was observed with increasing oral baclofen dose as weight increased (r = 0.43, P < 0.0001). Because of the variability in dosing between Gross Motor Function Classification System levels, prescribing oral baclofen for pediatric patients with cerebral palsy may not follow the traditional model of weight-based dosing seen in other pediatric conditions.
American journal of physical medicine & rehabilitation / Association of Academic Physiatrists
Administration, Oral; Adolescent; Baclofen; Body Weight; Cerebral Palsy; Child; Child, Preschool; Cross-Sectional Studies; Disability Evaluation; Female; Humans; Infant; Male; Muscle Relaxants, Central; Practice Patterns, Physicians'; Retrospective Studies; Young Adult
Adolescent; Baclofen; Body Weight; Cerebral Palsy; Disability Evaluation; Muscle Relaxants
McLaughlin MJ, Ratnasingam D, McGhee E. Variability of Steady State Oral Baclofen Prescribing Practices in Pediatric Patients With Cerebral Palsy. Am J Phys Med Rehabil. 2020;99(5):441-443. doi:10.1097/PHM.0000000000001334