Document Type

Article

Publication Date

10-2024

Identifier

DOI: 10.1002/cpt.3405

Abstract

The Pharmacogene Variation Consortium (PharmVar) serves as a global repository providing star (*) allele nomenclature for the polymorphic human CYP4F2 gene. CYP4F2 genetic variation impacts the metabolism of vitamin K, which is associated with warfarin dose requirements, and the metabolism of drugs, such as imatinib or fingolimod, and certain endogenous compounds including vitamin E and eicosanoids. This GeneFocus provides a comprehensive overview and summary of CYP4F2 genetic variation including the characterization of 14 novel star alleles, CYP4F2*4 through *17. A description of how haplotype information cataloged by PharmVar is utilized by the Pharmacogenomics Knowledgebase (PharmGKB) and the Clinical Pharmacogenetics Implementation Consortium (CPIC) is also provided.

Journal Title

Clinical pharmacology and therapeutics

Volume

116

Issue

4

First Page

963

Last Page

975

MeSH Keywords

Humans; Cytochrome P450 Family 4; Pharmacogenetics; Haplotypes; Alleles; Genetic Variation; Pharmacogenomic Variants

Keywords

Cytochrome P450 Family 4; Pharmacogenetics; Haplotypes; Alleles; Genetic Variation; Pharmacogenomic Variants

Comments

Grants and funding

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Publisher's Link: https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.3405

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