Document Type
Article
Publication Date
10-2024
Identifier
DOI: 10.1002/cpt.3387
Abstract
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various drugs. Thus, genetic variation can substantially contribute to the function of this enzyme and associated efficacy and safety. This GeneFocus provides an overview of the clinical significance of CYP2A6, including its genetic variation and function. We also highlight and discuss caveats in the identification and characterization of allelic variation of this complex pharmacogene, a prerequisite for accurate genotype determination and prediction of phenotype status.
Journal Title
Clinical pharmacology and therapeutics
Volume
116
Issue
4
First Page
948
Last Page
962
MeSH Keywords
Humans; Cytochrome P-450 CYP2A6; Pharmacogenetics; Genetic Variation; Phenotype; Nicotine; Genotype; Pharmacogenomic Variants; Alleles; Polymorphism, Genetic
Keywords
Cytochrome P-450 CYP2A6; Pharmacogenetics; Genetic Variation; Phenotype; Nicotine; Genotype; Pharmacogenomic Variants; Alleles; Genetic Polymorphism
Recommended Citation
Langlois AWR, Chenoweth MJ, Twesigomwe D, et al. PharmVar GeneFocus: CYP2A6. Clin Pharmacol Ther. 2024;116(4):948-962. doi:10.1002/cpt.3387
Comments
Grants and funding
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Publisher's Link: https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.3387