Predictive Performance of Existing Population Pharmacokinetic Models of Tacrolimus in Pediatric Kidney Transplant Recipients

Authors

Alenka Chapron, Children's Mercy Hospital, Kansas City, MOFollow
Susan M. Abdel-Rahman, Children's Mercy HospitalFollow

Publication Date

5-2019

Files

Abstract

With the goal of developing a clinician-driven tacrolimus (TAC) pharmacokinetic dosing tool, our initial objectives were 1) to examine whether published TAC population pharmacokinetic (popPK) models could serve as a foundation for the dosing tool, and 2) evaluate their performance predicting TAC concentrations in an independent cohort of Children's Mercy patients.

MeSH Keywords

Tacrolimus/pharmacokinetics; Tacrolimus/administration & dosage; Kidney Transplantation; Child; Adolescent; Infant

Keywords

Population pharmacokinetics; Renal Transplantation

Disciplines

Medical Pharmacology | Pediatrics | Pharmaceutical Preparations

Notes

Presented at the Children's Mercy Kansas City Research Days, May 2019.

Recommended Citation

Chapron, Alenka and Abdel-Rahman, Susan M., "Predictive Performance of Existing Population Pharmacokinetic Models of Tacrolimus in Pediatric Kidney Transplant Recipients" (2019). Posters. 107.
https://scholarlyexchange.childrensmercy.org/posters/107