Viral Whole Genome Sequencing for Antiviral Resistance in a Child with DOCK8 Deficiency and Recurrent HSV-1

Authors

Sean Stout, Children's Mercy HospitalFollow
A. L. Greninger
Rangaraj Selvarangan, Children's Mercy HospitalFollow
A. F. Freeman
Brandon D. Newell, Children's Mercy HospitalFollow
Erin Stahl, Children's Mercy HospitalFollow
Dwight Yin, Children's Mercy HospitalFollow

Publication Date

5-2019

Files

Mentor, Preceptor, Principle Investigator

Mentor: Dwight Yin MD, MPH

Abstract

We present the case of a child with dedicator of cytokinesis 8 (DOCK8) deficiency and chronic, resistant HSV-1 mucocutaneous infections to illustrate the clinical utility of viral whole genome sequencing to detect active and latent HSV resistance mutations.

MeSH Keywords

DOCK8 protein, human; Herpesvirus 1, Human; Drug Resistance, Viral; Whole Genome Sequencing; Child; Adolescent

Keywords

DOCK8 Deficiency; HSV-1

Disciplines

Infectious Disease | Medical Genetics | Pediatrics | Skin and Connective Tissue Diseases | Virus Diseases

Notes

Presented at the Children's Mercy Kansas City Research Days, May 2019

Recommended Citation

Stout, Sean; Greninger, A. L.; Selvarangan, Rangaraj; Freeman, A. F.; Newell, Brandon D.; Stahl, Erin; and Yin, Dwight, "Viral Whole Genome Sequencing for Antiviral Resistance in a Child with DOCK8 Deficiency and Recurrent HSV-1" (2019). Posters. 111.
https://scholarlyexchange.childrensmercy.org/posters/111