Presenter Status
Fellow
Abstract Type
Research
Primary Mentor
Shannon Carpenter
Start Date
12-5-2023 11:30 AM
End Date
12-5-2023 1:30 PM
Presentation Type
Poster-Restricted Access
Description
Background: Patients with bleeding disorders have greater propensity for blood loss and therefore may have a higher prevalence of iron deficiency when compared to the general population. However, current literature focuses on adolescent females and few studies have assessed the overall prevalence of iron deficiency in children with inherited bleeding disorders.
Hypothesis: Children with inherited bleeding disorders will have an increased prevalence of iron deficiency compared to children in the general population.
Analysis: This study represents a retrospective analysis of children with any inherited bleeding disorder seen in Children’s Mercy Hospital’s Hemophilia Treatment Center between 2010 and 2020. Iron deficiency was defined by recently published serum ferritin thresholds outlined by the National Health and Nutrition Examination Surveys. Concomitant iron deficiency risk factors were included in the analysis. Results: There were 798 patients with inherited bleeding disorders who were included in this analysis. Of the 306 patients who had serum ferritin collected, 162 (53%) had iron deficiency. In patients who had iron deficiency, 68% were female and 48% were aged 6 to 15 years. Notably, of the 129 (26%) males with serum ferritin collected, 40% had iron deficiency. The proportion of patients who had iron deficiency in each age group is displayed in figure 1. Of the 757 patients who had blood counts measured, 346 (46%) were anemic. Of the patients with anemia, 232 (67%) were male. The proportion of anemic patients in each age group is displayed in figure 2. Only 9 (6%) of the patients found to be iron deficient had other iron deficiency risk factors. The prevalence of iron deficiency in our cohort is considerably higher than the 10% prevalence estimated in the general pediatric population. Prior epidemiologic analysis of iron deficiency and anemia is mostly focused on adolescent females. However, the high prevalence of anemia in males with inherited bleeding disorders suggests that they are at comparable risk. Considering only 24% of males had ferritin collected, it is possible that the prevalence of iron deficiency in males is higher than this report suggests.
MeSH Keywords
Iron deficiency; Inherited bleeding disorders; Anemia
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Prevalence of Iron Deficiency in Patients with Inherited Bleeding Disorders
Background: Patients with bleeding disorders have greater propensity for blood loss and therefore may have a higher prevalence of iron deficiency when compared to the general population. However, current literature focuses on adolescent females and few studies have assessed the overall prevalence of iron deficiency in children with inherited bleeding disorders.
Hypothesis: Children with inherited bleeding disorders will have an increased prevalence of iron deficiency compared to children in the general population.
Analysis: This study represents a retrospective analysis of children with any inherited bleeding disorder seen in Children’s Mercy Hospital’s Hemophilia Treatment Center between 2010 and 2020. Iron deficiency was defined by recently published serum ferritin thresholds outlined by the National Health and Nutrition Examination Surveys. Concomitant iron deficiency risk factors were included in the analysis. Results: There were 798 patients with inherited bleeding disorders who were included in this analysis. Of the 306 patients who had serum ferritin collected, 162 (53%) had iron deficiency. In patients who had iron deficiency, 68% were female and 48% were aged 6 to 15 years. Notably, of the 129 (26%) males with serum ferritin collected, 40% had iron deficiency. The proportion of patients who had iron deficiency in each age group is displayed in figure 1. Of the 757 patients who had blood counts measured, 346 (46%) were anemic. Of the patients with anemia, 232 (67%) were male. The proportion of anemic patients in each age group is displayed in figure 2. Only 9 (6%) of the patients found to be iron deficient had other iron deficiency risk factors. The prevalence of iron deficiency in our cohort is considerably higher than the 10% prevalence estimated in the general pediatric population. Prior epidemiologic analysis of iron deficiency and anemia is mostly focused on adolescent females. However, the high prevalence of anemia in males with inherited bleeding disorders suggests that they are at comparable risk. Considering only 24% of males had ferritin collected, it is possible that the prevalence of iron deficiency in males is higher than this report suggests.
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