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Works from 2020

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Severe cutaneous adverse reactions: comparing outcomes in children with and without complex chronic conditions., James W Antoon, Jennifer Goldman, and Brian R. Lee (Article)

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Long-Distance Phasing of a Tentative "Enhancer" Single-Nucleotide Polymorphism With YP2D6 Star Allele Definitions, Erin C. Boone, Wendy Y. Wang, R Gaedigk, Mariana Cherner, Anick Bérard, J Steven Leeder, Neil A. Miller, and Andrea Gaedigk (Article)

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A Moving Target-Vancomycin Therapeutic Monitoring, Alaina N. Burns and Jennifer Goldman (Article)

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CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia., Monpat Chamnanphon, Sorawit Wainipitapong, Teeravut Wiwattarangkul, Phenphichcha Chuchuen, Kunathip Nissaipan, Weeraya Phaisal, Sookjaroen Tangwongchai, Chonlaphat Sukasem, Supeecha Wittayalertpanya, Andrea Gaedigk, Daruj Aniwattanapong, and Pajaree Chariyavilaskul (Article)

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The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites., Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk, and J Steven Leeder (Article)

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Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities., Jean C. Dinh, Chelsea Hosey-Cojocari, and Bridgette Jones (Article)

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Developmental Expression of SULT1C4 Transcript Variants in Human Liver: Implications for Discordance Between SULT1C4 mRNA and Protein Levels., Sarah Dubaisi, Hailin Fang, Joseph A. Caruso, R Gaedigk, Carrie A. Vyhlidal, Thomas A. Kocarek, and Melissa Runge-Morris (Article)

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Use of telemedicine to provide clinical pharmacy services during the SARS-CoV-2 pandemic., Claire Elson, Christopher M. Oermann, Stephanie Duehlmeyer, and Sarah Bledsoe (Letter to the Editor)

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PharmVar and the Landscape of Pharmacogenetic Resources., Andrea Gaedigk, Michelle Whirl-Carrillo, Victoria M. Pratt, Neil A. Miller, and Teri E. Klein (Article)

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A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy., J Kevin Hicks, Jeffrey R. Bishop, Roseann S. Gammal, Katrin Sangkuhl, Chad A. Bousman, J Steven Leeder, Adrián Llerena, Daniel J. Mueller, Laura B. Ramsey, Stuart A. Scott, Todd C. Skaar, Kelly E. Caudle, Teri E. Klein, and Andrea Gaedigk (Article)

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Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD., Priyadarshini Kachroo, Jarrett D. Morrow, Alvin T. Kho, Carrie A. Vyhlidal, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, and Dawn L. DeMeo (Article)

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Transfer learning enables prediction of CYP2D6 haplotype function., Gregory McInnes, Rachel Dalton, Katrin Sangkuhl, Michelle Whirl-Carrillo, Seung-Been Lee, Philip S. Tsao, Andrea Gaedigk, Russ B. Altman, and Erica L. Woodahl (Article)

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Serum amoxicillin levels in young infants (0-59 days) with sepsis treated with oral amoxicillin., Fatima Mir, Robin E. Pearce, Naila Baig-Ansari, Shamim Qazi, Jeffrey S Barrett, Susan M. Abdel-Rahman, Greg Kearns, and Anita Km Zaidi (Article)

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Comment on "Transition to two-bag intravenous acetylcysteine for acetaminophen overdose"., Michael E Mullins, Mark C Yarema, Marco L A Sivilotti, Margaret Thompson, Michael C Beuhler, D Adam Algren, and Christopher P Holstege (Response or Comment)

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Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity., Valentina Shakhnovich and Kathyrn Kyler (Response or Comment)

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Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance., Erica L. Toth, John D. Clarke, Iván L Csanaky, and Nathan J. Cherrington (Article)

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Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, and J Steven Leeder (Article)

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Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport., Jonathan B. Wagner, Melissa Ruggiero, J Steven Leeder, and Bruno Hagenbuch (Article)

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Ontogeny Related Changes in the Pediatric Liver Metabolome., Christopher M. Wilson, Qian Li, R Gaedigk, Chengpeng Bi, Saskia N. de Wildt, J Steven Leeder, and Brooke L. Fridley (Article)

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Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years., Haeyoung Zhang, Abdul Basit, Chris Wolford, Kuan-Fu Chen, Andrea Gaedigk, Yvonne S Lin, J Steven Leeder, and Bhagwat Prasad (Article)

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Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice., Youcai Zhang, Andrew J. Lickteig, Jing Liu, Iván L Csanaky, and Curtis D. Klaassen (Article)

Works from 2019

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Facilitating Informed Permission/Assent/Consent in Pediatric Clinical Trials., Susan M. Abdel-Rahman (Article)

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Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial., Anna Boronat, Julian Mateus, Natalia Soldevila-Domenech, Mercè Guerra, Jose Rodríguez-Morató, Carlota Varon, Daniel Muñoz, Francina Barbosa, Juan Carlos Morales, Andrea Gaedigk, Klaus Langohr, Maria-Isabel Covas, Clara Pérez-Mañá, Montserrat Fitó, Rachel F. Tyndale, and Rafael de la Torre (Article)

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Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans., Anna Boronat, Julian Mateus, Natalia Soldevila-Domenech, Mercè Guerra, Jose Rodríguez-Morató, Carlota Varon, Daniel Muñoz, Francina Barbosa, Juan Carlos Morales, Andrea Gaedigk, Klaus Langohr, Maria-Isabel Covas, Clara Pérez-Mañá, Montserrat Fitó, Rachel F. Tyndale, and Rafael de la Torre (Article)

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Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles., Mariana R. Botton, Xingwu Lu, Geping Zhao, Elena Repnikova, Yoshinori Seki, Andrea Gaedigk, Eric E. Schadt, Lisa Edelmann, and Stuart A. Scott (Article)

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Improving Recognition and Reporting of Adverse Drug Reactions in the NICU: A Quality Improvement Project., Betsy Cammack, Alexandra Oschman, and Tamorah R. Lewis MD PhD (Article)

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy., Zeruesenay Desta, Roseann S. Gammal, Li Gong, Michelle Whirl-Carrillo, Aditya H. Gaur, Chonlaphat Sukasem, Jennifer Hockings, Alan Myers, Marelize Swart, Rachel F. Tyndale, Collen Masimirembwa, Otito F. Iwuchukwu, Sanika Chirwa, Jeffrey Lennox, Andrea Gaedigk, Teri E. Klein, and David W. Haas (Article)

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Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit., Jamesia Donato, Karishma Rao, and Tamorah R. Lewis MD PhD (Article)

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Pharmacogenetics: Chasing Perfection., Andrea Gaedigk (Editorial)

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Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project., Andrea Gaedigk, Amy Turner, Robin E. Everts, Stuart A. Scott, Praful Aggarwal, Ulrich Broeckel, Gwendolyn A. McMillin, Roberta Melis, Erin C. Boone, Victoria M. Pratt, and Lisa V. Kalman (Article)

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The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children., Roseann S. Gammal, Kelly E. Caudle, Charles T. Quinn, Winfred C. Wang, Andrea Gaedigk, Cynthia A. Prows, Cyrine E. Haidar, Annette K. Taylor, Teri E. Klein, Katrin Sangkuhl, Jane S. Hankins, and Kristine R. Crews (Article)

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Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement., Jennifer Goldman, Wen-Hung Chung, Brian R. Lee, Chun-Bing Chen, Chun-Wei Lu, Wolfram Hoetzenecker, Robert Micheletti, Sally Usdin Yasuda, David J. Margolis, Neil H. Shear, Jeffery P. Struewing, and Munir Pirmohamed (Article)

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Population pharmacokinetics of sildenafil in extremely premature infants., Daniel Gonzalez, Matthew M. Laughon, P Brian Smith, Shufan Ge, Namasivayam Ambalavanan, Andrew Atz, Gregory M. Sokol, Chi D. Hornik, Dan Stewart, Gratias Mundakel, Brenda B. Poindexter, R Gaedigk, Mary Mills, Michael Cohen-Wolkowiez, Karen Martz, Christoph P. Hornik, and Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee (Article)

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Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen., Sibo Jiang, Valvanera Vozmediano, Susan M. Abdel-Rahman, Stephan Schmidt, and Laura P. James (Article)

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Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children, Kathyrn Kyler, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Kevin Watt, and Valentina Shakhnovich (Article)

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Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism., Mayur K. Ladumor, Deepak Kumar Bhatt, Andrea Gaedigk, Sheena Sharma, Aarzoo Thakur, Robin E. Pearce, J Steven Leeder, Michael B. Bolger, Saranjit Singh, and Bhagwat Prasad (Article)

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Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data., J Steven Leeder (Article)

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Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples., Cindy Yanfei Li, Chelsea Hosey-Cojocari, Abdul Basit, Jashvant D Unadkat, J Steven Leeder, and Bhagwat Prasad (Article)

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Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy., Matthew J. McLaughlin, Susan M. Abdel-Rahman, and J Steven Leeder (Article)

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Considerations for Implementing Precision Therapeutics for Children., Matthew J. McLaughlin, Jonathan B. Wagner, Valentina Shakhnovich, Bruce Carleton, and J Steven Leeder (Article)

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An electronic medical records-based approach to identify idiosyncratic drug-induced liver injury in children., Tracy L. Sandritter, Jennifer Goldman, Clayton J Habiger, James F. Daniel, Jennifer Lowry, and Ryan T. Fischer (Article)

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Visible-Light-Activated High-Density Materials for Controlled in Vivo Insulin Release., Bhagyesh R. Sarode, Karen Kover, and Simon H. Friedman (Article)

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Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity, Valentina Shakhnovich, Susan M. Abdel-Rahman, Craig A. Friesen, J. Weigel, Robin E. Pearce, Andrea Gaedigk, J Steven Leeder, and G. L. Kearns (Article)

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Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model., Rakesh K. Singh, Leon van Haandel, Paul Kiptoo, Mara L. Becker, Teruna J. Siahaan, and Ryan S. Funk (Article)

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Naltrexone Reduces Binge Eating and Purging in Adolescents in an Eating Disorder Program., Stephani L. Stancil, William P. Adelman, Amanda Dietz, and Susan M. Abdel-Rahman (Article)

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Children Are Not Small Adults: Specific Findings in Statin Exposure and Response in a Growing Population., Jonathan B. Wagner (Article)

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Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, R Gaedigk, Andrea Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Ralph Kauffman, Leon Van Haandel, and J Steven Leeder (Article)

Works from 2018

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Variability of surgical prophylaxis in penicillin-allergic children., David F. Butler, Brian R. Lee, Sarah Suppes, Tracy Sandritter, Jason G. Newland, Lory Harte, and Jennifer Goldman (Article)

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Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure., Jeremie H. Estepp, Paweł Wiczling, Joseph Moen, Guolian Kang, Joana Marie Mack, Robert Liem, Julie A. Panepinto, Uttam Garg, Gregory Kearns, and Kathleen A. Neville (Article)

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It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm, Valentina Shakhnovich (Editorial)

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A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents, Valentina Shakhnovich, P. Brian Smith, Jeffrey T. Guptill, Laura P. James, David N. Collier, Huali Wu, Chad E. Livingston, Jian Zhao, Gregory L. Kearns, and Michael Cohen-Wolkowiez (Article)

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Reply, Valentina Shakhnovich, P. Brian Smith, Huali Wu, Michael Cohen-Wolkowiez, and Gregory L. Kearns (Letter to the Editor)

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Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics., Jonathan B. Wagner, Susan M. Abdel-Rahman, Leon Van Haandel, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Ralph Kauffman, and J Steven Leeder (Article)

Works from 2017

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Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants., Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J Steven Leeder, and Bhagwat Prasad (Article)

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A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants., Alain Cuna, S Govindarajan, Alexandra Oschman, H Dai, K Brophy, Michael Norberg, and William E. Truog (Article)

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Prediction of CYP2D6 phenotype from genotype across world populations., Andrea Gaedigk, Katrin Sangkuhl, Michelle Whirl-Carrillo, Teri Klein, and J Steven Leeder (Article)

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Variability in Antifungal and Antiviral Use in Hospitalized Children., Jennifer L. Goldman, Rachael K. Ross, Brian R. Lee, Jason G. Newland, Adam L. Hersh, Matthew P. Kronman, and Jeffrey S. Gerber (Article)

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Intravenous Versus Oral Antibiotics for the Prevention of Treatment Failure in Children With Complicated Appendicitis: Has the Abandonment of Peripherally Inserted Catheters Been Justified?, Shawn J. Rangel, Brett R. Anderson, Rajendu Srivastava, Samir S. Shah, Paul Ishimine, Mythili Srinivasan, Matthew Bryan, Wu Gong, Matt Hall, Russell Localio, Xianqun Luan, Seema Anandalwar, Ron Keren, and Pediatric Research in Inpatient Settings (PRIS) Network (Article)

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Metronidazole Metabolism in Neonates and the Interplay Between Ontogeny and Genetic Variation., Laura A. Wang, Daniel Gonzalez, J Steven Leeder, Rachel F. Tyndale, Robin E. Pearce, Daniel K. Benjamin, Gregory L. Kearns, Michael Cohen-Wolkowiez, and Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (Article)

Works from 2016

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A Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantitation of Plasma Busulfan., Shuang Deng, Michael Kiscoan, C. Clinton Frazee III, Susan M. Abdel-Rahman, Jignesh Dalal, and Uttam Garg (Article)

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Pharmacogenetic comparison of CYP2D6 predictive and measured phenotypes in a South African cohort., T M. Dodgen, C De J De J Labuschagne, A van Schalkwyk, F E. Steffens, Andrea Gaedigk, A D. Cromarty, M Alessandrini, and M S. Pepper (Article)

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Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology., Uttam Garg and Yan Victoria Zhang (Article)

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Bioactivation of Trimethoprim to Protein-Reactive Metabolites in Human Liver Microsomes., Jennifer Goldman, Yakov M. Koen, Steven A. Rogers, Kelin Li, J Steven Leeder, and Robert P. Hanzlik (Article)

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Tablet/Capsule Size Variation Among the Most Commonly Prescribed Medications for Children in the USA: Retrospective Review and Firsthand Pharmacy Audit., Laura Jacobsen, Kathy Riley, Brian R. Lee, Kathleen Bradford, and Ravi Jhaveri (Article)

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Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting., L V. Kalman, Jag Agúndez, M Lindqvist Appell, J L. Black, G C. Bell, S Boukouvala, C Bruckner, E Bruford, K Caudle, S A. Coulthard, A K. Daly, Al Del Tredici, J T. den Dunnen, K Drozda, R E. Everts, D Flockhart, R R. Freimuth, Andrea Gaedigk, H Hachad, T Hartshorne, M Ingelman-Sundberg, T E. Klein, V M. Lauschke, D R. Maglott, H L. McLeod, G A. McMillin, U A. Meyer, D J. Müller, D A. Nickerson, W S. Oetting, M Pacanowski, V M. Pratt, M V. Relling, A Roberts, W S. Rubinstein, K Sangkuhl, M Schwab, S A. Scott, S C. Sim, R K. Thirumaran, L H. Toji, R F. Tyndale, Rhn van Schaik, M Whirl-Carrillo, KTJ Yeo, and U M. Zanger (Article)

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Clindamycin-susceptibility rates of methicillin-resistant staphylococcus aureus varies by infection type in pediatric patients, Amanda Li, Rangaraj Selvarangan, Richard K. Ogden Jr., Brandon French, and Diana Yu (Article)

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Stochastic nonlinear mixed effects: a metformin case study., Brett Matzuka, Jason Chittenden, Jonathan Monteleone, and Hien Tran (Article)

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Cetirizine Quantification by High-Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)., Ada Munar, C. Clinton Frazee III, Bridgette Jones, and Uttam Garg (Article)

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Yinzhihuang attenuates ANIT-induced intrahepatic cholestasis in rats through upregulation of Mrp2 and Bsep expressions., Qiao-Qun Ou, Xin-Hua Qian, Ding-You Li, You-Xiang Zhang, Xia-Nan Pei, Jin-Wen Chen, and Li Yu (Article)

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Quantification of Free Phenytoin by Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS)., Judy Peat, C. Clinton Frazee III, and Uttam Garg (Article)

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Ontogeny of Hepatic Drug Transporters as Quantified by LC-MS/MS Proteomics., B Prasad, Andrea Gaedigk, M Vrana, R Gaedigk, J Steven Leeder, L Salphati, X Chu, G Xiao, Ceca Hop, R Evers, L Gan, and J D Unadkat (Article)

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Comprehensive Urine Drug Screen by Gas Chromatography/Mass Spectrometry (GC/MS)., Bheemraj Ramoo, Melissa Funke, C. Clinton Frazee III, and Uttam Garg (Article)

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CYP450 genotype and pharmacogenetic association studies: a critical appraisal., Rashmi R. Shah, Andrea Gaedigk, Adrián LLerena, Michel Eichelbaum, Julia Stingl, and Robert L. Smith (Article)

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Long-term velaglucerase alfa treatment in children with Gaucher disease type 1 naïve to enzyme replacement therapy or previously treated with imiglucerase., Laurie Smith, William Rhead, Joel Charrow, Suma P. Shankar, Ashish Bavdekar, Nicola Longo, Rebecca Mardach, Paul Harmatz, Thomas Hangartner, Hak-Myung Lee, Eric Crombez, and Gregory M. Pastores (Article)

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Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene,, Greyson P. Twist, Andrea Gaedigk, Neil A. Miller, Emily G. Farrow, Laurel K. Willig, Darrell L. Dinwiddie, Josh E. Petrikin, Sarah E. Soden, Suzanne Herd, Margaret Gibson, Julie A. Cakici, Amanda K. Riffel, J Steven Leeder, Deendayal Dinakarpandian, and Stephen F. Kingsmore (Article)

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Quantification of pravastatin acid, lactone and isomers in human plasma by UHPLC-MS/MS and its application to a pediatric pharmacokinetic study., Leon van Haandel, Kim T. Gibson, J Steven Leeder, and Jonathan B. Wagner (Article)

Works from 2015

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Comparative effectiveness of intravenous vs oral antibiotics for postdischarge treatment of acute osteomyelitis in children., Ron Keren, Samir S. Shah, Rajendu Srivastava, Shawn Rangel, Michael Bendel-Stenzel, Nada Harik, John Hartley, Michelle Lopez, Luis Seguias, Joel Tieder, Matthew Bryan, Wu Gong, Matt Hall, Russell Localio, Xianqun Luan, Rachel deBerardinis, Allison Parker, Pediatric Research in Inpatient Settings Network, and Jeffrey D. Colvin (Article)

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CYP2D7 Sequence Variation Interferes with TaqMan CYP2D6 (*) 15 and (*) 35 Genotyping., Amanda K. Riffel, Mehdi Dehghani, Toinette Hartshorne, Kristen C. Floyd, J Steven Leeder, Kevin P. Rosenblatt, and Andrea Gaedigk (Article)

Works from 2014

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General considerations for pediatric oral drug formulation, Valentina Shakhnovich and Susan M. Abdel-Rahman (Book Chapter)

Works from 2013

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Pediatric pharmacokinetics., Jonathan B. Wagner and Susan M. Abdel-Rahman (Article)