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Works from 2022

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Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans., Deepak Ahire, Abdul Basit, Lisa J. Christopher, Ramaswamy Iyer, J Steven Leeder, and Bhagwat Prasad (Article)

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Parental understanding and attitudes following pharmacogenomic testing for pediatric neuropsychiatric patients., Courtney D. Berrios, Sophia K. Sadaro, Tracy L. Sandritter, Jennifer A. Wagner, Sarah E. Soden, Benjamin Black, and Susan Abdel-Rahman (Article)

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CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study, E Ricky Chan, Rajeev K. Mehlotra, Karim A Pirani, Arsene C. Ratsimbasoa, Scott M. Williams, Andrea Gaedigk, and Peter A. Zimmerman (Article)

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The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity., Jean C. Dinh, Erin C. Boone, Vincent S. Staggs, Robin E. Pearce, Wendy Y. Wang, Roger Gaedigk, J Steven Leeder, and Andrea Gaedigk (Article)

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Utility of the 13C-pantoprazole breath test as a CYP2C19 phenotyping probe for children, Keith Feldman, Gregory L. Kearns, Robin E. Pearce, Susan M. Abdel-Rahman, J Steven Leeder, Alec Friesen, Vincent S. Staggs, Andrea Gaedigk, Jaylene Weigel, and Valentina Shakhnovich (Article)

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CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project., Andrea Gaedigk, Erin C. Boone, Steven E. Scherer, Seung-Been Lee, Ibrahim Numanagić, Cenk Sahinalp, Joshua D. Smith, Sean McGee, Aparna Radhakrishnan, Xiang Qin, Wendy Y. Wang, Emily G. Farrow, Nina Gonzaludo, Aaron L. Halpern, Deborah A. Nickerson, Neil A. Miller, Victoria M. Pratt, and Lisa V. Kalman (Article)

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A cross-sectional study of the relationship between CYP2D6 and CYP2C19 variations and depression symptoms, for women taking SSRIs during pregnancy., Catriona Hippman, Caitlin Slomp, Emily Morris, Rolan Batallones, Angela Inglis, Prescilla Carrion, Ursula Brain, Michelle Higginson, Galen E B Wright, Lynda G. Balneaves, Deirdre Ryan, Corey Nislow, Colin J D Ross, Andrea Gaedigk, Tim F. Oberlander, and Jehannine Austin (Article)

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Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models., Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, and J Steven Leeder (Article)

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Considering metformin as a second-line treatment for children and adolescents with prediabetes., Chelsea M Hosey, Kelsee Halpin, and Yun Yan (Article)

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Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future., J Steven Leeder (Article)

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Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver., J Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad, and Robin E. Pearce (Article)

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Case Report: Pharmacogenetics Applied to Precision Psychiatry Could Explain the Outcome of a Patient With a New CYP2D6 Genotype, Elena Marcos-Vadillo, Lorena Carrascal-Laso, Ignacio Ramos-Gallego, Andrea Gaedigk, Belén García-Berrocal, Eduardo Mayor-Toranzo, Alfonso Sevillano-Jiménez, Almudena Sánchez, María Isidoro-García, and Manuel Franco-Martín (Article)

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Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy., María Celsa Peña-Martín, Belén García-Berrocal, Almudena Sánchez-Martín, Elena Marcos-Vadillo, María Jesús García-Salgado, Santiago Sánchez, Carolina Lorenzo, David González-Parra, Francisco Sans, Manuel Franco, Andrea Gaedigk, María José Mateos-Sexmero, Catalina Sanz, and María Isidoro-García (Article)

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CYP2D6*9 and *41: Does the Activity Value Assigned to these Alleles Need to be Reduced to more Accurately Predict Phenotype?, Laura B. Ramsey and Andrea Gaedigk (Article)

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Ehrlichia-induced hemophagocytic lymphohistiocytosis in a pediatric kidney transplant recipient., Nisha S. Singh, Alexa L. Pagano, J Allyson Hays, Alexander Kats, Steven M. Dahl, Bradley A. Warady, Nathan T. Beins, and Dwight E. Yin (Article)

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The Impact of Age and Genetics on Naltrexone Biotransformation., Stephani L. Stancil, Whitney M. Nolte, Robin E. Pearce, Vincent S. Staggs, and J Steven Leeder (Article)

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Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG)., Marwan K. Tayeh, Andrea Gaedigk, Matthew P. Goetz, Teri E. Klein, Elaine Lyon, Gwendolyn A. McMillin, Stefan Rentas, Marwan Shinawi, Victoria M. Pratt, Stuart A. Scott, and ACMG Laboratory Quality Assurance Committee (Article)

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Simultaneous quantification of trimethoprim metabolites in pediatric plasma., Robert T. Tessman, Whitney M. Nolte, Paul C. Toren, Kim T. Gibson, Linda Vu, and Jennifer Goldman (Article)

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The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping, Ya Feng Wen, Andrea Gaedigk, Erin C. Boone, Wendy Y. Wang, and Robert J. Straka (Article)

Works from 2021

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A Pilot Comparison of High- Versus Low-Tech Palatability Assessment Tools in Young Children., Susan M. Abdel-Rahman, Shasha Bai, Patricia A. Porter-Gill, Grace A. Goode, and Gregory L. Kearns (Article)

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Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act., Susan M. Abdel-Rahman, Ian M. Paul, Chi Hornik, Janice E. Sullivan, Kelly Wade, Paula Delmore, Gaurav Sharma, Daniel K. Benjamin, and Kanecia O. Zimmerman (Article)

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Editorial: NSAIDs Pharmacogenomics., José A G Agúndez, Christine Formea, Andrea Gaedigk, Elena García-Martín, Li Gong, Tilo Grosser, Craig R. Lee, and Katherine N. Theken (Editorial)

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Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans., Nadia O. Bamfo, Chelsea Hosey-Cojocari, Leslie Z. Benet, and Connie M. Remsberg (Article)

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PharmVar GeneFocus: CYP2C19., Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, José A G Agúndez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, and Andrea Gaedigk (Article)

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Review and Consensus on Pharmacogenomic Testing in Psychiatry., Chad A. Bousman, Susanne A. Bengesser, Katherine J. Aitchison, Azmeraw T. Amare, Harald Aschauer, Bernhard T. Baune, Bahareh Behroozi Asl, Jeffrey R. Bishop, Margit Burmeister, Boris Chaumette, Li-Shiun Chen, Zachary A. Cordner, Jürgen Deckert, Franziska Degenhardt, Lynn E. DeLisi, Lasse Folkersen, James L. Kennedy, Teri E. Klein, Joseph L. McClay, Francis J. McMahon, Richard Musil, Nancy L. Saccone, Katrin Sangkuhl, Robert M. Stowe, Ene-Choo Tan, Arun K. Tiwari, Clement C. Zai, Gwyneth Zai, Jianping Zhang, Andrea Gaedigk, and Daniel J. Müller (Article)

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CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice., Daniel Carranza-Leon, Alyson L. Dickson, Andrea Gaedigk, C Michael Stein, and Cecilia P. Chung (Article)

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Influence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients, Monpat Chamnanphon, Rattanaporn Sukprasong, Andrea Gaedigk, Weerawat Manosuthi, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya, Napatrupron Koomdee, Thawinee Jantararoungtong, Apichaya Puangpetch, and Chonlaphat Sukasem (Article)

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Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy., Kristine R. Crews, Andrew A. Monte, Rachel Huddart, Kelly E. Caudle, Evan D. Kharasch, Andrea Gaedigk, Henry M. Dunnenberger, J Steven Leeder, John T. Callaghan, Caroline Flora Samer, Teri E. Klein, Cyrine E. Haidar, Sara L. Van Driest, Gualberto Ruano, Katrin Sangkuhl, Larisa H. Cavallari, Daniel J. Müller, Cynthia A. Prows, Mohamed Nagy, Andrew A. Somogyi, and Todd C. Skaar (Article)

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PharmVar GeneFocus: CYP2B6., Zeruesenay Desta, Ahmed El-Boraie, Li Gong, Andrew A. Somogyi, Volker M. Lauschke, Collet Dandara, Kathrin Klein, Neil A. Miller, Teri E. Klein, Rachel F. Tyndale, Michelle Whirl-Carrillo, and Andrea Gaedigk (Article)

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Too Much of a Good Thing: Defining Antimicrobial Therapeutic Targets to Minimize Toxicity., Kevin J. Downes and Jennifer Goldman (Article)

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Perceived Harm May Be Helpful: Fear of Fluoroquinolone-Associated Adverse Events in Children., Rana El Feghaly and Jennifer Goldman (Editorial)

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Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective., Chance S. Friesen, Sherwin S. Chan, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Iván L Csanaky, and Valentina Shakhnovich (Article)

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Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy., Chance S. Friesen, Chelsea Hosey-Cojocari, Sherwin S. Chan, Iván L. Csanaky, Jonathan B. Wagner, Brooke Sweeney, Alec Friesen, Jason D. Fraser, and Valentina Shakhnovich (Article)

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Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation., Andrea Gaedigk, Scott T. Casey, Michelle Whirl-Carrillo, Neil A. Miller, and Teri E. Klein (Article)

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Scholarly Productivity in Clinical Pharmacology Amid Pandemic-Related Workforce Disruptions: Are Men and Women Affected Equally?, Alethea B. Gerding, Sharon J. Swan, Kimberly A. Brayer, and Susan M. Abdel-Rahman (Editorial)

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Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics., Daniel L. Hertz, Laura B. Ramsey, Mathangi Gopalakrishnan, J Steven Leeder, and Sara L. Van Driest (Article)

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Pharmacogenomics Factors Influencing the Effect of Risperidone on Prolactin Levels in Thai Pediatric Patients With Autism Spectrum Disorder., Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Roger Gaedigk, Wiranpat Kittitharaphan, Nattawat Ngamsamut, Penkhae Limsila, Apichaya Puangpetch, Rattanaporn Sukprasong, and Chonlaphat Sukasem (Article)

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Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone., Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, and Chonlaphat Sukasem (Article)

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Resolving discordant CYP2D6 genotyping results in Thai subjects: platform limitations and novel haplotypes, Yaowaluck Hongkaew, Wendy Y. Wang, R Gaedigk, Chonlaphat Sukasem, and Andrea Gaedigk (Article)

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Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure., Khursheed Iqbal, Stephen H. Pierce, Keisuke Kozai, Pramod Dhakal, Regan L. Scott, Katherine F Roby, Carrie A. Vyhlidal, and Michael J. Soares (Article)

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Promoting Culture Change Within Organizations., Bridgette Jones, Catherine Cheng, Lisa M. Foglia, Hope Ricciotti, and Wendi Willis El-Amin (Article)

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Methods for Detecting Pediatric Adverse Drug Reactions From the Electronic Medical Record., Lydia M. Joyner, Leah A. Alicea, Jennifer Goldman, Sarah Suppes, and Emma M. Tillman (Article)

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DNA methylation perturbations may link altered development and aging in the lung., Priyadarshini Kachroo, Jarrett D. Morrow, Carrie A. Vyhlidal, R Gaedigk, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, and Dawn L. DeMeo (Article)

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update., Jason H. Karnes, Allan E. Rettie, Andrew A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, Adrian Llerena, Michelle Whirl-Carrillo, Teri E. Klein, Elizabeth J. Phillips, Scott Mintzer, Andrea Gaedigk, Kelly E. Caudle, and John T. Callaghan (Article)

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Clinical Outcome and Antibiotic Dosing Differences by Weight in Children With Acute Osteomyelitis., Kathyrn Kyler, Brian R. Lee, Earl F. Glynn, Joel P Waddell, Mark A. Hoffman, and Jennifer Goldman (Article)

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing., John J. Lima, Cameron D. Thomas, Julia Barbarino, Zeruesenay Desta, Sara L. Van Driest, Nihal El Rouby, Julie A. Johnson, Larisa H. Cavallari, Valentina Shakhnovich, David L. Thacker, Stuart A. Scott, Matthias Schwab, Chakradhara Rao S Uppugunduri, Christine M. Formea, James P. Franciosi, Katrin Sangkuhl, Andrea Gaedigk, Teri E. Klein, Roseann S. Gammal, and Takahisa Furuta (Article)

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The effect of race and supplementation on maternal and umbilical cord plasma folates., Devika Maulik, Leon van Haandel, Jenifer Allsworth, Kris S Chaisanguanthum, John D Yeast, and J Steven Leeder (Article)

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CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar, Rajeev K. Mehlotra, Andrea Gaedigk, Rosalind E. Howes, Tovonahary A. Rakotomanga, Arsene C. Ratsimbasoa, and Peter A. Zimmerman (Article)

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Trimethoprim-Sulfamethoxazole-associated Fulminant Respiratory Failure in Children and Young Adults., Jenna Miller, Angela R. Shih, Mari Mino-Kenudson, Martin S. Taylor, and Jennifer Goldman (Article)

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Brief Motivational Intervention to Improve Adolescent Sexual Health Service Uptake: A Pilot Randomized Controlled Trial in the Emergency Department., Melissa K. Miller, Delwyn Catley, Amber Adams, Vincent S. Staggs, M Denise Dowd, Stephani L. Stancil, Elizabeth Miller, Catherine L. Satterwhite, José Bauermeister, and Kathy Goggin (Article)

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Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital., Madhavi Murali, Sarah Suppes, Keith Feldman, and Jennifer Goldman (Article)

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Precision dosing of vancomycin: in defence of AUC-guided therapy in children., Mark E. Murphy, Sonya Tang Girdwood, Jennifer Goldman, Marc H. Scheetz, and Kevin J. Downes (Article)

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Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population, Thuraya M. Mutawi, Mohamed M. Zedan, Raida S. Yahya, Mahmoud M. Zakria, Mamdouh R. El-Sawi, and Andrea Gaedigk (Article)

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Recommendations for Clinical CYP2D6 Genotyping Allele Selection: A Joint Consensus Recommendation of the Association for Molecular Pathology, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, and the European Society for Pharmacogenomics and Personalized Therapy., Victoria M. Pratt, Larisa H. Cavallari, Andria L. Del Tredici, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa V. Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, R H N van Schaik, Michelle Whirl-Carrillo, and Karen E. Weck (Article)

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Characterization of Reference Materials with an Association for Molecular Pathology Pharmacogenetics Working Group Tier 2 Status: CYP2C9, CYP2C19, VKORC1, CYP2C Cluster Variant, and GGCX: A GeT-RM Collaborative Project., Victoria M. Pratt, Amy Turner, Ulrich Broeckel, D Brian Dawson, Andrea Gaedigk, Ty C. Lynnes, Elizabeth B. Medeiros, Ann M. Moyer, Deborah Requesens, Francesco Vetrini, and Lisa V. Kalman (Article)

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Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital., Timothy A. Roberts, Jennifer A. Wagner, Tracy L. Sandritter, Benjamin T. Black, Andrea Gaedigk, and Stephani L. Stancil (Article)

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PharmVar GeneFocus: CYP2C9., Katrin Sangkuhl, Karla Claudio-Campos, Larisa H. Cavallari, Jose A G Agundez, Michelle Whirl-Carrillo, Jorge Duconge, Andria L. Del Tredici, Mia Wadelius, Mariana Rodrigues Botton, Erica L. Woodahl, Stuart A. Scott, Teri E. Klein, Victoria M. Pratt, Ann K. Daly, and Andrea Gaedigk (Article)

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Developmental Considerations for the Use of Naltrexone in Children and Adolescents., Stephani L. Stancil, Susan M. Abdel-Rahman, and Jonathan B. Wagner (Article)

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Adolescent perceptions of pharmacogenetic testing., Stephani L. Stancil, Courtney D. Berrios, and Susan M. Abdel-Rahman (Article)

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Long-acting reversible contraceptives (LARCs) as harm reduction: a qualitative study exploring views of women with histories of opioid misuse., Stephani L. Stancil, Melissa K. Miller, Alex Duello, Sarah Finocchario-Kessler, Kathy Goggin, Rachel P. Winograd, and Emily A. Hurley (Article)

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Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date., Stephani L. Stancil, Fuad Mirzayev, and Susan M. Abdel-Rahman (Article)

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Neurodevelopmental outcomes in preterm infants with retinopathy of prematurity., Hao Tan, Patricia Blasco, Tamorah R. Lewis, Susan Ostmo, Michael F. Chiang, and John Peter Campbell (Article)

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Ontogeny of Drug-Metabolizing Enzymes., Aarzoo Thakur, Md Masud Parvez, J Steven Leeder, and Bhagwat Prasad (Article)

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Evaluating and Mitigating Risk of Acute Kidney Injury with the Combination of Vancomycin and Piperacillin-Tazobactam in Children., Emma M. Tillman and Jennifer Goldman (Article)

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Enhancing Pediatric Adverse Drug Reaction Documentation in the Electronic Medical Record., Emma M Tillman, Sarah Suppes, Keith Feldman, and Jennifer Goldman (Article)

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Risks and mitigation strategies to prevent etoposide infusion-related reactions in children., Emma M. Tillman, Sarah Suppes, Nicholas Miles, Ashley M. Duty, Kelsey L. Kelley, and Jennifer Goldman (Article)

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Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization., Amy J. Turner, Praful Aggarwal, Erin C. Boone, Cyrine-Eliana Haidar, Mary V. Relling, Ashley D Derezinski, Ulrich Broeckel, and Andrea Gaedigk (Article)

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Loss of Consciousness in the Young Child., Juan Villafane, Jacob R. Miller, Julie Glickstein, Jonathan N Johnson, Jonathan B. Wagner, Chris S. Snyder, Tatiana Filina, Scott L. Pomeroy, S Kristen Sexson-Tejtel, Caitlin Haxel, Jason Gottlieb, Pirooz Eghtesady, and Devyani Chowdhury (Article)

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Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine., Carrie A. Vyhlidal, Brian D. Chapron, Atif Ahmed, Vivekanand Singh, Rebecca Casini, and Valentina Shakhnovich (Article)

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Is this the end for ranitidine? NDMA presence continues to confound., Jennifer A. Wagner, Jean C. Dinh, Jennifer R. Lightdale, Benjamin D. Gold, and Jennifer Colombo (Article)

Works from 2020

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Severe cutaneous adverse reactions: comparing outcomes in children with and without complex chronic conditions., James W Antoon, Jennifer Goldman, and Brian R. Lee (Article)

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Long-Distance Phasing of a Tentative "Enhancer" Single-Nucleotide Polymorphism With YP2D6 Star Allele Definitions, Erin C. Boone, Wendy Y. Wang, R Gaedigk, Mariana Cherner, Anick Bérard, J Steven Leeder, Neil A. Miller, and Andrea Gaedigk (Article)

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A Moving Target-Vancomycin Therapeutic Monitoring, Alaina N. Burns and Jennifer Goldman (Article)

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CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia., Monpat Chamnanphon, Sorawit Wainipitapong, Teeravut Wiwattarangkul, Phenphichcha Chuchuen, Kunathip Nissaipan, Weeraya Phaisal, Sookjaroen Tangwongchai, Chonlaphat Sukasem, Supeecha Wittayalertpanya, Andrea Gaedigk, Daruj Aniwattanapong, and Pajaree Chariyavilaskul (Article)

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The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites., Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk, and J Steven Leeder (Article)

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Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities., Jean C. Dinh, Chelsea Hosey-Cojocari, and Bridgette Jones (Article)

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Developmental Expression of SULT1C4 Transcript Variants in Human Liver: Implications for Discordance Between SULT1C4 mRNA and Protein Levels., Sarah Dubaisi, Hailin Fang, Joseph A. Caruso, R Gaedigk, Carrie A. Vyhlidal, Thomas A. Kocarek, and Melissa Runge-Morris (Article)

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Use of telemedicine to provide clinical pharmacy services during the SARS-CoV-2 pandemic., Claire Elson, Christopher M. Oermann, Stephanie Duehlmeyer, and Sarah Bledsoe (Letter to the Editor)

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Foundational health content in environmental studies, sciences, and sustainability education: report of a workshop, Elizabeth Friedman, Sasha Adkins, and Tee L. Guidotti (Article)

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PharmVar and the Landscape of Pharmacogenetic Resources., Andrea Gaedigk, Michelle Whirl-Carrillo, Victoria M. Pratt, Neil A. Miller, and Teri E. Klein (Article)

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A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy., J Kevin Hicks, Jeffrey R. Bishop, Roseann S. Gammal, Katrin Sangkuhl, Chad A. Bousman, J Steven Leeder, Adrián Llerena, Daniel J. Mueller, Laura B. Ramsey, Stuart A. Scott, Todd C. Skaar, Kelly E. Caudle, Teri E. Klein, and Andrea Gaedigk (Article)

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Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children., Sibo Jiang, Kumpal Madrasi, Tanay Samant, Chakradhar Lagishetty, Valvanera Vozmediano, Angela Chiew, Susan M. Abdel-Rahman, Laura P. James, and Stephan Schmidt (Article)

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Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD., Priyadarshini Kachroo, Jarrett D. Morrow, Alvin T. Kho, Carrie A. Vyhlidal, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, and Dawn L. DeMeo (Article)

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Evidence demonstrating the pharmacist's direct impact on clinical outcomes in pediatric patients: An opinion of the pediatrics practice and research network of the American College of Clinical Pharmacy, Joseph LaRochelle, Katherine Smith, Sandra Benavides, Kelly Bobo, Allison Chung, Elizabeth Farrington, Audrey R. Kennedy, David Knoppert, Bernard Lee, Kalen Manasco, Rebecca Pettit, Hanna Phan, Amy Potts, Tracy L. Sandritter, and Tracy Hagemann (Article)

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Transfer learning enables prediction of CYP2D6 haplotype function., Gregory McInnes, Rachel Dalton, Katrin Sangkuhl, Michelle Whirl-Carrillo, Seung-Been Lee, Philip S. Tsao, Andrea Gaedigk, Russ B. Altman, and Erica L. Woodahl (Article)

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Serum amoxicillin levels in young infants (0-59 days) with sepsis treated with oral amoxicillin., Fatima Mir, Robin E. Pearce, Naila Baig-Ansari, Shamim Qazi, Jeffrey S Barrett, Susan M. Abdel-Rahman, Greg Kearns, and Anita Km Zaidi (Article)

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Comment on "Transition to two-bag intravenous acetylcysteine for acetaminophen overdose"., Michael E Mullins, Mark C Yarema, Marco L A Sivilotti, Margaret Thompson, Michael C Beuhler, D Adam Algren, and Christopher P Holstege (Response or Comment)

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Screening trimethoprim primary metabolites for covalent binding to albumin, Whitney M. Nolte, Robert T. Tessman, and Jennifer Goldman (Article)

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Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity., Valentina Shakhnovich and Kathyrn Kyler (Response or Comment)

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Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk., Sunita Sharma, Alvin T. Kho, Divya Chhabra, Kathleen Haley, Carrie A. Vyhlidal, R Gaedigk, J Steven Leeder, Kelan G. Tantisira, Benjamin Raby, and Scott T. Weiss (Article)

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Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance., Erica L. Toth, John D. Clarke, Iván L Csanaky, and Nathan J. Cherrington (Article)

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Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, and J Steven Leeder (Article)

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Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport., Jonathan B. Wagner, Melissa Ruggiero, J Steven Leeder, and Bruno Hagenbuch (Article)

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Ontogeny Related Changes in the Pediatric Liver Metabolome., Christopher M. Wilson, Qian Li, R Gaedigk, Chengpeng Bi, Saskia N. de Wildt, J Steven Leeder, and Brooke L. Fridley (Article)

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Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years., Haeyoung Zhang, Abdul Basit, Chris Wolford, Kuan-Fu Chen, Andrea Gaedigk, Yvonne S Lin, J Steven Leeder, and Bhagwat Prasad (Article)

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Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice., Youcai Zhang, Andrew J. Lickteig, Jing Liu, Iván L Csanaky, and Curtis D. Klaassen (Article)

Works from 2019

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Facilitating Informed Permission/Assent/Consent in Pediatric Clinical Trials., Susan M. Abdel-Rahman (Article)

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Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial., Anna Boronat, Julian Mateus, Natalia Soldevila-Domenech, Mercè Guerra, Jose Rodríguez-Morató, Carlota Varon, Daniel Muñoz, Francina Barbosa, Juan Carlos Morales, Andrea Gaedigk, Klaus Langohr, Maria-Isabel Covas, Clara Pérez-Mañá, Montserrat Fitó, Rachel F. Tyndale, and Rafael de la Torre (Article)

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Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans., Anna Boronat, Julian Mateus, Natalia Soldevila-Domenech, Mercè Guerra, Jose Rodríguez-Morató, Carlota Varon, Daniel Muñoz, Francina Barbosa, Juan Carlos Morales, Andrea Gaedigk, Klaus Langohr, Maria-Isabel Covas, Clara Pérez-Mañá, Montserrat Fitó, Rachel F. Tyndale, and Rafael de la Torre (Article)

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Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles., Mariana R. Botton, Xingwu Lu, Geping Zhao, Elena Repnikova, Yoshinori Seki, Andrea Gaedigk, Eric E. Schadt, Lisa Edelmann, and Stuart A. Scott (Article)