Works from 2025
The Pharmacogenomics Global Research Network Implementation Working Group: global collaboration to advance pharmacogenetic implementation., Larisa H. Cavallari, J Kevin Hicks, Jai N. Patel, Amanda L. Elchynski, D Max Smith, Salma A. Bargal, Ashley Fleck, Christina L. Aquilante, Shayna R. Killam, Lauren Lemke, Taichi Ochi, Laura Ramsey, Cyrine E. Haidar, Teresa Ho, Nihal El Rouby, Andrew A. Monte, Josiah D. Allen, Amber L. Beitelshees, Jeffrey R. Bishop, Chad Bousman, Ronald Campbell, Emily J. Cicali, Kelsey J. Cook, Benjamin Duong, Evangelia Eirini Tsermpini, Sonya Tang Girdwood, David B. Gregornik, Kristin N. Grimsrud, Nathan Lamb, James C. Lee, Rocio Ortiz Lopez, Tinashe Adrian Mazhindu, Sarah A. Morris, Mohamed Nagy, Jenny Nguyen, Amy L. Pasternak, Natasha Petry, Ron H N van Schaik, April Schultz, Todd C. Skaar, Hana Al Alshaykh, James M. Stevenson, Rachael M. Stone, Nam K. Tran, Sony Tuteja, Erica L. Woodahl, Li-Chi Yuan, and Craig R. Lee (Article)
Works from 2024
Dopamine Transporter and CYP2D6 Gene Relationships with Attention-Deficit/Hyperactivity Disorder Treatment Response in the Methylphenidate and Atomoxetine Crossover Study, Jeffrey R. Bishop, Chuan Zhou, Andrea Gaedigk, Beth Krone, Rick Kittles, Edwin H. Cook, Jeffrey H. Newcorn, and Mark A. Stein (Article)
Toxicity profile of high-dose methotrexate in young children with central nervous system tumors., Ashley N. Chavana, Zachary L. Taylor, Nicholas DeGroote, Holly B. Lindsay, Hannah E. Sauer, Emily J. Mason, Eric S. Schafer, Tamara P. Miller, Sharon M. Castellino, Lauren Pommert, Maureen M. O'Brien, Laura Ramsey, M Brooke Bernhardt, and Austin L. Brown (Article)
Population Pharmacokinetic Analysis of Atomoxetine and its Metabolites in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder., Shen Cheng, Mahmoud Al-Kofahi, J Steven Leeder, and Jacob T. Brown (Article)
Hypoalbuminemia in children with acute lymphoblastic leukemia: relation to asparaginase therapy and impact on high dose methotrexate elimination., Sophie Rex Christensen, Christina Friis Jensen, Jesper Heldrup, Zachary Taylor, Laura Ramsey, and Steen Rosthøj (Article)
Characterization and visualization of tandem repeats at genome scale., Egor Dolzhenko, Adam English, Harriet Dashnow, Guilherme De Sena Brandine, Tom Mokveld, William J. Rowell, Caitlin Karniski, Zev Kronenberg, Matt C. Danzi, Warren A. Cheung, Chengpeng Bi, Emily G. Farrow, Aaron Wenger, Khi Pin Chua, Verónica Martínez-Cerdeño, Trevor D. Bartley, Peng Jin, David L. Nelson, Stephan Zuchner, Tomi Pastinen, Aaron R. Quinlan, Fritz J. Sedlazeck, and Michael A. Eberle (Article)
Clinical Pharmacogenetics Implementation Consortium Guideline (CPIC) for CYP2D6, ADRB1, ADRB2, ADRA2C, GRK4, and GRK5 Genotypes and Beta-Blocker Therapy., Julio D. Duarte, Cameron D. Thomas, Craig R. Lee, Rachel Huddart, Jose A G Agundez, Jordan F. Baye, Andrea Gaedigk, Teri E. Klein, David E. Lanfear, Andrew A. Monte, Mohamed Nagy, Matthias Schwab, C Michael Stein, Chakradhara Rao S. Uppugunduri, Ron H N van Schaik, Roseann S. Donnelly, Kelly E. Caudle, and Jasmine A. Luzum (Article)
The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation., Jonathan B. Edelson, Victor Zak, David Goldberg, Greg Fleming, Andrew S. Mackie, Jyoti K. Patel, Matthew Files, Tacy Downing, Marc Richmond, Ben Acheampong, Mark Cartoski, Jon Detterich, Brian McCrindle, Kimberly McHugh, Jesse E. Hansen, Jonathan B. Wagner, Michael Di Maria, Angela Weingarten, Todd Nowlen, Ja Kyoung Yoon, Gi Beom Kim, Richard Williams, Robert Whitehill, Edward Kirkpatrick, Suellen Yin, Peter Ermis, Adam M. Lubert, Mario Stylianou, D'Andrea Freemon, Chenwei Hu, Olukayode D. Garuba, Peter Frommelt, Bryan H. Goldstein, Stephen Paridon, Ruchira Garg, and Pediatric Heart Network Investigators (Article)
Clarification of adverse drug reactions by a pharmacovigilance team results in increased antibiotic re-prescribing at a freestanding United States children's hospital., Keith Feldman, Sarah Suppes, and Jennifer Goldman (Article)
Response to "DPYD genotyping panels: Impact of population diversity"., Andrea Gaedigk, Amy J. Turner, Cyrine E. Haidar, Philip E. Empey, and Steven M. Offer (Response or Comment)
Characterization of Reference Materials for DPYD: A GeT-RM Collaborative Project., Andrea Gaedigk, Amy J. Turner, Ann M. Moyer, Pablo Zubiaur, Erin C. Boone, Wendy Y. Wang, Ulrich Broeckel, and Lisa V. Kalman (Article)
Monte Carlo simulations of cefepime in children receiving continuous kidney replacement therapy support continuous infusions for target attainment., H Rhodes Hambrick, Nieko Punt, Kathryn Pavia, Tomoyuki Mizuno, Stuart L. Goldstein, and Sonya Tang Girdwood (Article)
Pharmacogenetic Factors Influence Escitalopram Pharmacokinetics and Adverse Events in Youth with a Family History of Bipolar Disorder: A Preliminary Study., Duncan C. Honeycutt, Thomas J. Blom, Laura Ramsey, Jeffrey R. Strawn, Kaitlyn M. Bruns, Jeffrey A. Welge, Luis R. Patino, Manpreet K. Singh, and Melissa P. DelBello (Article)
Hearing the Unheard: Voices of Black Emerging Adults With Uncontrolled Asthma., Bridgette Jones and Mahesh Padukudru Anand (Editorial)
Influence of CYP2D6 Metabolizer Status on Risperidone and Paliperidone Tolerability in Children and Adolescents., Amarachi A. Kanu, Michelle M. Johnston, Ethan A. Poweleit, Samuel E. Vaughn, Jeffrey R. Strawn, and Laura Ramsey (Article)
Influence of novel CYP2C-haplotype on proton pump inhibitor pharmacokinetics in children., Kathyrn Kyler, Andrea Gaedigk, Susan Abdel-Rahman, Vincent S. Staggs, Robin E. Pearce, Paul C. Toren, J Steven Leeder, and Valentina Shakhnovich (Article)
PharmVar GeneFocus: CYP2A6., Alec W R Langlois, Meghan J. Chenoweth, David Twesigomwe, Giada Scantamburlo, Michelle Whirl-Carrillo, Katrin Sangkuhl, Teri E. Klein, Charity Nofziger, Rachel F. Tyndale, and Andrea Gaedigk (Article)
Feasibility of adolescent contraceptive care in the pediatric emergency department: A pilot randomized controlled trial., Melissa K. Miller, Kathy Goggin, Stephani L. Stancil, Elizabeth Miller, Tara Ketterer, Vince Staggs, April McNeill-Johnson, Amber Adams, and Cynthia J. Mollen (Article)
From Dose to Exposure: Shifting the Paradigm of Pediatric Clinical Pharmacology Research and Education., Ronaldo Morales Junior, Victor Amajor, Kelli Paice, Kathyrn Kyler, H Rhodes Hambrick, Kathryn E. Pavia, Andrew S. Haynes, Felicia Gooden, Gwendolyn M. Pais, Kevin J. Downes, Laura Ramsey, Jonathan B. Wagner, and Sonya Tang Girdwood (Article)
Age-Dependent Abundance of CYP450 Enzymes Involved in Metronidazole Metabolism: Application to Pediatric PBPK Modeling., Md Masud Parvez, Aarzoo Thakur, Aanchal Mehrotra, Stephani L. Stancil, Robin E. Pearce, Abdul Basit, J Steven Leeder, and Bhagwat Prasad (Article)
Breath of Inequality: How Socioeconomic Factors Shape Asthma Outcomes., Ekta Perera, Bridgette Jones, and Mahboobeh Mahdavinia (Editorial)
Machine Learning-Based Prediction of Escitalopram and Sertraline Side Effects With Pharmacokinetic Data in Children and Adolescents., Ethan A. Poweleit, Samuel E. Vaughn, Zeruesenay Desta, Judith W. Dexheimer, Jeffrey R. Strawn, and Laura Ramsey (Article)
Understanding Health Equity in Patient-Reported Outcomes., Lourdes G. Ramirez, Margee Louisias, Princess U. Ogbogu, Alanna Stinson, Ruchi Gupta, Samantha Sansweet, Tarandeep Singh, Andrea Apter, Bridgette Jones, and Sharmilee M. Nyenhuis (Article)
The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker., Aarya Ramprasad, Adara Ezekwe, Brian R. Lee, Shiva Balasubramanian, and Bridgette Jones (Article)
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy., Katherine M. Robinson, Seenae Eum, Zeruesenay Desta, Rachel F. Tyndale, Andrea Gaedigk, Richard C. Crist, Cyrine E. Haidar, Alan L. Myers, Caroline F. Samer, Andrew A. Somogyi, Pablo Zubiaur, Otito F. Iwuchukwu, Michelle Whirl-Carrillo, Teri E. Klein, Kelly E. Caudle, Roseann S. Donnelly, and Evan D. Kharasch (Article)
Optimizing early phase clinical trial washout periods: a report from the Therapeutic Advances in Childhood Leukemia and Lymphoma consortium., Eric S. Schafer, Teresa Rushing, Kristine R. Crews, Colleen Annesley, Susan I. Colace, Nicole Kaiser, Lauren Pommert, Laura Ramsey, Himalee S. Sabnis, Kenneth Wong, Bill H. Chang, Todd M. Cooper, Nirali N. Shah, Susan R. Rheingold, Andrew E. Place, Yueh-Yun Chi, Deepa Bhojwani, Alan S. Wayne, and M Brooke Bernhardt (Article)
Pharmacogenetic testing in primary care could bolster depression treatment: A value proposition., Nina R. Sperber, Megan C. Roberts, Sarah Gonzales, Lisa M. Bendz, Deborah Cragun, Susanne B. Haga, R Ryanne Wu, Chioma Omeogu, Brystana Kaufman, Natasha J. Petry, Laura Ramsey, and Ryley Uber (Article)
Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond HLA-B*15:02, Stephani L. Stancil, Tracy L. Sandritter, and Jeffrey R. Strawn (Article)
Ontogeny of Human Liver Aldehyde Oxidase: Developmental Changes and Implications for Drug Metabolism., Sandhya Subash, Dilip K. Singh, Deepak Ahire, S Cyrus Khojasteh, Bernard P. Murray, Michael A. Zientek, Robert S. Jones, Priyanka Kulkarni, Faizan Zubair, Bill J. Smith, Scott Heyward, J Steven Leeder, and Bhagwat Prasad (Article)
Racial and Ethnic Representation in Food Allergen Immunotherapy Trial Participants: A Systematic Review., Hannah Suffian, Aarti Pandya, Lauren Davidson, Vincent Staggs, and Bridgette Jones (Article)
Opportunities for Pharmacogenetic Testing to Guide Dosing of Medications in Youths With Medicaid., Sonya Tang Girdwood, Matthew Hall, James W. Antoon, Kathryn Kyler, Derek J. Williams, Samir S. Shah, Lucas E. Orth, Jennifer Goldman, James A. Feinstein, and Laura B. Ramsey (Article)
Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study., Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López-Viñau López, Carmelo Rizzari, and Scott C. Howard (Article)
Sex and the Kidney Drug-Metabolizing Enzymes and Transporters: Are Preclinical Drug Disposition Data Translatable to Humans?, Aarzoo Thakur, Guihua Yue, Deepak Ahire, Vijaya S Mettu, Abrar Al Maghribi, Kaitlyn Ford, Lucia Peixoto, J Steven Leeder, and Bhagwat Prasad (Article)
Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing., Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, and Andrea Gaedigk (Article)
SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia, Jonathan B. Wagner, Susan Abdel-Rahman, Geetha Raghuveer, Andrea Gaedigk, Erin C. Boone, Roger Gaedigk, Vincent S. Staggs, Gregory A. Reed, Na Zhang, and J Steven Leeder (Article)
Pediatric Beta Blocker Therapy: A Comprehensive Review of Development and Genetic Variation to Guide Precision-Based Therapy in Children, Adolescents, and Young Adults., Mollie Walton and Jonathan B. Wagner (Article)
CYP2D6 copy number determination using digital PCR, Wendy Y. Wang, Lancy Lin, Erin C. Boone, Junko Stevens, and Andrea Gaedigk (Article)
Response to "What is the Current Clinical Impact of the CYP2C:TG Haplotype?"., Pablo Zubiaur, J Steven Leeder, Francisco Abad-Santos, and Andrea Gaedigk (Response or Comment)
PharmVar GeneFocus: CYP4F2., Pablo Zubiaur, Cristina Rodríguez-Antona, Erin C. Boone, Ann K. Daly, Evangelia Eirini Tsermpini, Lubna Q. Khasawneh, Katrin Sangkuhl, Jorge Duconge, Mariana R. Botton, Jessica Savieo, Charity Nofziger, Michelle Whirl-Carrillo, Teri E. Klein, and Andrea Gaedigk (Article)
Works from 2023
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants., Chad A. Bousman, James M. Stevenson, Laura B. Ramsey, Katrin Sangkuhl, J Kevin Hicks, Jeffrey R. Strawn, Ajeet B. Singh, Gualberto Ruaño, Daniel J. Mueller, Evangelia Eirini Tsermpini, Jacob T. Brown, Gillian C. Bell, J Steven Leeder, Andrea Gaedigk, Stuart A. Scott, Teri E. Klein, Kelly E. Caudle, and Jeffrey R. Bishop (Article)
Evaluating treatment outcomes in pharmacogenomic-guided care for major depression: A rapid review and meta-analysis., Mary Bunka, Gavin Wong, Dan Kim, Louisa Edwards, Jehannine Austin, Mary M. Doyle-Waters, Andrea Gaedigk, and Stirling Bryan (Article)
Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism., Estee Y. Cramer, Jacquelaine Bartlett, Ernest R. Chan, Andrea Gaedigk, Arsene C. Ratsimbasoa, Rajeev K. Mehlotra, Scott M. Williams, and Peter A. Zimmerman (Article)
Standardization of Fertility Preservation Discussion Among Pediatric Oncology and Bone Marrow Transplant Patients: A Single Institution Experience., Chandni Dargan, Sarah Mc Dermott, Shelby Chesbro, Amanda Trout, Nancy Terwilliger, Tennille Hilyard, Ashley Flynn, and Joy M. Fulbright (Article)
Characterization of Reference Materials for CYP3A4 and CYP3A5: A (GeT-RM) Collaborative Project., Andrea Gaedigk, Erin C. Boone, Amy J. Turner, Ron H N van Schaik, Dilyara Chernova, Wendy Y. Wang, Ulrich Broeckel, Caitlin A. Granfield, Jennelle C. Hodge, Reynold C. Ly, Ty C. Lynnes, Matthew W. Mitchell, Ann M. Moyer, Jason Oliva, and Lisa V. Kalman (Article)
Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach., Rose N. Gelineau-Morel, Christopher Smyser, and J Steven Leeder (Article)
The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis., David J. Goldberg, Chenwei Hu, Adam M. Lubert, Rahul H. Rathod, Daniel J. Penny, Christopher J. Petit, Kurt R. Schumacher, Salil Ginde, Richard V. Williams, J K Yoon, Gi Beom Kim, Todd T. Nowlen, Michael V. DiMaria, Benjamin P. Frischhertz, Jonathan B. Wagner, Kimberly E. McHugh, Brian W. McCrindle, Mark J. Cartoski, Jon A. Detterich, Anji T. Yetman, Anitha S. John, Marc E. Richmond, Delphine Yung, R Mark Payne, Andrew S. Mackie, Christopher K. Davis, Shabana Shahanavaz, Kevin D. Hill, Marisa Almaguer, Victor Zak, Michael G. McBride, Bryan H. Goldstein, Gail D. Pearson, Stephen M. Paridon, and Pediatric Heart Network Investigators (Article)
Pharmacogenetic Testing in Patients with Autism Spectrum Disorder Evaluated in a Precision Medicine Clinic., Rachel Goodson, Jennifer Wagner, Tracy L. Sandritter, Vincent S. Staggs, Sarah E. Soden, and Cy Nadler (Article)
Committing to genomic answers for all kids: Evaluating inequity in genomic research enrollment., Natalie J. Kane, Ana S A Cohen, Courtney D. Berrios, Bridgette Jones, T Pastinen, and Mark A. Hoffman (Article)
Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens., Oyinlade Kehinde, Laura B. Ramsey, Andrea Gaedigk, and Akinyemi Oni-Orisan (Article)
Peak Oxygen Consumption (V̇O 2peak ) Recovery Delay in a Pediatric Fontan Population., Karoline Krzywda, Kelli M. Teson, Jessica S. Watson, Suma Goudar, Daniel Forsha, Jonathan B. Wagner, and David A. White (Article)
Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life., Wojciech Krzyzanski, Bradley Stockard, Andrea Gaedigk, Allison Scott, Whitney M. Nolte, Kim T. Gibson, J Steven Leeder, and Tamorah Lewis (Article)
The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma., Kathyrn Kyler and Bridgette Jones (Editorial)
Multidisciplinary Approach to Deciphering Etoposide Infusion Reactions and Potential Role of Polyethersulfone Filter Membranes., Nicholas Miles, Andi Masters, Zeruesenay Desta, Jennifer Goldman, Sarah Suppes, and Emma M. Tillman (Article)
Case report: Use of therapeutic drug monitoring and pharmacogenetic testing as opportunities to individualize care in a case of flecainide toxicity after fetal supraventricular tachycardia., Ronald Palmen, Tracy L. Sandritter, Lindsey Malloy-Walton, Christopher Follansbee, and Jonathan B. Wagner (Article)
CYP3A4 and CYP3A5 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase., Victoria M. Pratt, Larisa H. Cavallari, Makenzie L. Fulmer, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa V. Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, Ron H N van Schaik, Michelle Whirl-Carrillo, and Karen E. Weck (Article)
PharmVar GeneFocus: SLCO1B1., Laura B. Ramsey, Li Gong, Seung-Been Lee, Jonathan B. Wagner, Xujia Zhou, Katrin Sangkuhl, Solomon M. Adams, Robert J. Straka, Philip E. Empey, Erin C. Boone, Teri E. Klein, Mikko Niemi, and Andrea Gaedigk (Article)
Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug-Gene Pairs to Know., Tracy L. Sandritter, Rachel Chevalier, Rebecca Abt, and Valentina Shakhnovich (Article)
A longitudinal analysis of the effect of anemia on executive functions in children with mild to moderate chronic kidney disease., Nisha S. Singh, Rebecca J. Johnson, Matthew B. Matheson, Joann Carlson, Stephen R. Hooper, and Bradley A. Warady (Article)
Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver., Stephani L. Stancil, Robin E. Pearce, Vincent S. Staggs, and J Steven Leeder (Article)
Characterization of complex structural variation in the CYP2D6-CYP2D7-CYP2D8 gene loci using single-molecule long-read sequencing, Amy J. Turner, Ashley D. Derezinski, Andrea Gaedigk, Mark E. Berres, David B. Gregornik, Keith Brown, Ulrich Broeckel, and Gunter Scharer (Article)
PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting., Amy J. Turner, Charity Nofziger, Bronwyn E. Ramey, Reynold C. Ly, Chad A. Bousman, José A G Agúndez, Katrin Sangkuhl, Michelle Whirl-Carrillo, Simone Vanoni, Henry M. Dunnenberger, Gualberto Ruaño, Martin A. Kennedy, Michael S. Phillips, Houda Hachad, Teri E. Klein, Ann M. Moyer, and Andrea Gaedigk (Article)
Novel expansion of a well-established antimicrobial stewardship program: Enhancing program efficiency and reach., Ann L. Wirtz, Brian R. Lee, Alaina N. Burns, Ryan McDonough, Tammy Frank, Darrell E. Hall, Kate Vanlandingham, and Jennifer Goldman (Article)
Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity., Pablo Zubiaur, Paula Soria-Chacartegui, Erin C. Boone, Bhagwat Prasad, Jean Dinh, Wendy Y. Wang, Santiago Zugbi, Andrea Rodríguez-Lopez, Eva González-Iglesias, J Steven Leeder, Francisco Abad-Santos, and Andrea Gaedigk (Article)
Works from 2022
Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans., Deepak Ahire, Abdul Basit, Lisa J. Christopher, Ramaswamy Iyer, J Steven Leeder, and Bhagwat Prasad (Article)
Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic acid (SSDA) as a Urinary Biomarker of Cytochrome P450 2D6 (CYP2D6) Activity., Andrew C. Behrle, Justin Douglas, J Steven Leeder, and Leon van Haandel (Article)
Parental understanding and attitudes following pharmacogenomic testing for pediatric neuropsychiatric patients., Courtney D. Berrios, Sophia K. Sadaro, Tracy L. Sandritter, Jennifer A. Wagner, Sarah E. Soden, Benjamin Black, and Susan Abdel-Rahman (Article)
CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study, E Ricky Chan, Rajeev K. Mehlotra, Karim A Pirani, Arsene C. Ratsimbasoa, Scott M. Williams, Andrea Gaedigk, and Peter A. Zimmerman (Article)
Recent advances in the ontogeny of drug disposition., Brian D. Chapron, Alenka Chapron, and J Steven Leeder (Article)
Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective., Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, J Steven Leeder, Dwaipayan Mukherjee, Kunal Taskar, Manthena V S Varma, Xinyuan Zhang, Xinning Yang, and Aleksandra Galetin (Article)
The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity., Jean C. Dinh, Erin C. Boone, Vincent S. Staggs, Robin E. Pearce, Wendy Y. Wang, Roger Gaedigk, J Steven Leeder, and Andrea Gaedigk (Article)
Novel Oncogenic PDGFRB Variant in Severe Infantile Myofibromatosis With Response to Imatinib Using Therapeutic Drug Monitoring, Abbey Elsbernd, Boutaina Boulouadnine, Atif Ahmed, Midhat S. Farooqi, Tracy L. Sandritter, Valentina Shakhnovich, Darius Blanding, Jean-Baptiste Demoulin, and Joel Thompson (Article)
Utility of the 13C-pantoprazole breath test as a CYP2C19 phenotyping probe for children, Keith Feldman, Gregory L. Kearns, Robin E. Pearce, Susan M. Abdel-Rahman, J Steven Leeder, Alec Friesen, Vincent S. Staggs, Andrea Gaedigk, Jaylene Weigel, and Valentina Shakhnovich (Article)
CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project., Andrea Gaedigk, Erin C. Boone, Steven E. Scherer, Seung-Been Lee, Ibrahim Numanagić, Cenk Sahinalp, Joshua D. Smith, Sean McGee, Aparna Radhakrishnan, Xiang Qin, Wendy Y. Wang, Emily G. Farrow, Nina Gonzaludo, Aaron L. Halpern, Deborah A. Nickerson, Neil A. Miller, Victoria M. Pratt, and Lisa V. Kalman (Article)
A cross-sectional study of the relationship between CYP2D6 and CYP2C19 variations and depression symptoms, for women taking SSRIs during pregnancy., Catriona Hippman, Caitlin Slomp, Emily Morris, Rolan Batallones, Angela Inglis, Prescilla Carrion, Ursula Brain, Michelle Higginson, Galen E B Wright, Lynda G. Balneaves, Deirdre Ryan, Corey Nislow, Colin J D Ross, Andrea Gaedigk, Tim F. Oberlander, and Jehannine Austin (Article)
Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models., Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, and J Steven Leeder (Article)
Considering metformin as a second-line treatment for children and adolescents with prediabetes., Chelsea M Hosey, Kelsee Halpin, and Yun Yan (Article)
Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future., J Steven Leeder (Article)
Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver., J Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad, and Robin E. Pearce (Article)
A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence., J Steven Leeder, Andrea Gaedigk, Krista J. Wright, Vincent S. Staggs, Sarah E. Soden, Yvonne S. Lin, and Robin E. Pearce (Article)
Dosing Variability and Clinical Outcomes of Oxybutynin: A Pediatric Cohort of Patients With Neurogenic Bladder., Mahnoor F. Malik, Joseph Hogan Randall, Jack G. Campbell, Matthew J. McLaughlin, and Joel F Koenig (Article)
Case Report: Pharmacogenetics Applied to Precision Psychiatry Could Explain the Outcome of a Patient With a New CYP2D6 Genotype, Elena Marcos-Vadillo, Lorena Carrascal-Laso, Ignacio Ramos-Gallego, Andrea Gaedigk, Belén García-Berrocal, Eduardo Mayor-Toranzo, Alfonso Sevillano-Jiménez, Almudena Sánchez, María Isidoro-García, and Manuel Franco-Martín (Article)
Therapeutic plasma exchange for multiorgan dysfunction among critically ill pediatric patients with leukemia: A single-institutional experience., Sarah E. Mc Dermott, Chandni Dargan, Elizabeth Gonzalez, Lejla Music Aplenc, Terrie Flatt, and Nazia Iqbal (Article)
Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy., María Celsa Peña-Martín, Belén García-Berrocal, Almudena Sánchez-Martín, Elena Marcos-Vadillo, María Jesús García-Salgado, Santiago Sánchez, Carolina Lorenzo, David González-Parra, Francisco Sans, Manuel Franco, Andrea Gaedigk, María José Mateos-Sexmero, Catalina Sanz, and María Isidoro-García (Article)
TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase., Victoria M. Pratt, Larisa H. Cavallari, Makenzie L. Fulmer, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa V. Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, R H N van Schaik, Michelle Whirl-Carrillo, and Karen E. Weck (Article)
Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project., Victoria M. Pratt, Wendy Y. Wang, Erin C. Boone, Ulrich Broeckel, Neal Cody, Lisa Edelmann, Andrea Gaedigk, Ty C. Lynnes, Elizabeth B. Medeiros, Ann M. Moyer, Matthew W. Mitchell, Stuart A. Scott, Petr Starostik, Amy Turner, and Lisa V. Kalman (Article)
CYP2D6*9 and *41: Does the Activity Value Assigned to these Alleles Need to be Reduced to more Accurately Predict Phenotype?, Laura B. Ramsey and Andrea Gaedigk (Article)
PharmVar GeneFocus: CYP3A5., Cristina Rodriguez-Antona, Jessica L. Savieo, Volker M. Lauschke, Katrin Sangkuhl, Britt I. Drögemöller, Danxin Wang, Ron H N van Schaik, Andrei A. Gilep, Arul P. Peter, Erin C. Boone, Bronwyn E. Ramey, Teri E. Klein, Michelle Whirl-Carrillo, Victoria M. Pratt, and Andrea Gaedigk (Article)
Ehrlichia-induced hemophagocytic lymphohistiocytosis in a pediatric kidney transplant recipient., Nisha S. Singh, Alexa L. Pagano, J Allyson Hays, Alexander Kats, Steven M. Dahl, Bradley A. Warady, Nathan T. Beins, and Dwight E. Yin (Article)
The Impact of Age and Genetics on Naltrexone Biotransformation., Stephani L. Stancil, Whitney M. Nolte, Robin E. Pearce, Vincent S. Staggs, and J Steven Leeder (Article)
Effects of genotype and food on naltrexone exposure in adolescents., Stephani L. Stancil, Michaela Voss, Whitney M. Nolte, John Tumberger, William Adelman, and Susan Abdel-Rahman (Article)
Pharmacometabolomics Profiling of Preterm Infants Validates Patterns of Metabolism Associated With Response to Dexamethasone Treatment for Bronchopulmonary Dysplasia., Bradley Stockard, Cheri Gauldin, William E. Truog, and Tamorah Lewis (Article)
Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population., Sudeep D. Sunthankar, Prince J. Kannankeril, Andrea Gaedigk, Andrew E. Radbill, Frank A. Fish, and Sara L. Van Driest (Article)
Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG)., Marwan K. Tayeh, Andrea Gaedigk, Matthew P. Goetz, Teri E. Klein, Elaine Lyon, Gwendolyn A. McMillin, Stefan Rentas, Marwan Shinawi, Victoria M. Pratt, Stuart A. Scott, and ACMG Laboratory Quality Assurance Committee (Article)
Simultaneous quantification of trimethoprim metabolites in pediatric plasma., Robert T. Tessman, Whitney M. Nolte, Paul C. Toren, Kim T. Gibson, Linda Vu, and Jennifer Goldman (Article)
A consensus statement on the use of botulinum toxin in pediatric patients., Joshua A. Vova, Michael M. Green, Joline E. Brandenburg, Loren Davidson, Andrea Paulson, Supreet Deshpande, Joyce L. Oleszek, Didem Inanoglu, and Matthew J. McLaughlin (Article)
Characterization of Novel CYP2D6 Alleles across Sub-Saharan African Populations, Wendy Y. Wang, David Twesigomwe, Charity Nofziger, Amy J. Turner, Lena-Sophie Helmecke, Ulrich Broeckel, Ashley D. Derezinski, Scott Hazelhurst, and Andrea Gaedigk (Article)
The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping, Ya Feng Wen, Andrea Gaedigk, Erin C. Boone, Wendy Y. Wang, and Robert J. Straka (Article)
Use of pharmacogenetics for benzodiazepine prescription: state of the art and expectations., Pablo Zubiaur and Francisco Abad-Santos (Editorial)
CYP2C18: the orphan in the CYP2C family., Pablo Zubiaur and Andrea Gaedigk (Editorial)
Works from 2021
A Pilot Comparison of High- Versus Low-Tech Palatability Assessment Tools in Young Children., Susan M. Abdel-Rahman, Shasha Bai, Patricia A. Porter-Gill, Grace A. Goode, and Gregory L. Kearns (Article)
