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Works from 2021

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A Pilot Comparison of High- Versus Low-Tech Palatability Assessment Tools in Young Children., Susan M. Abdel-Rahman, Shasha Bai, Patricia A. Porter-Gill, Grace A. Goode, and Gregory L. Kearns (Article)

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Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act., Susan M. Abdel-Rahman, Ian M. Paul, Chi Hornik, Janice E. Sullivan, Kelly Wade, Paula Delmore, Gaurav Sharma, Daniel K. Benjamin, and Kanecia O. Zimmerman (Article)

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Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans., Nadia O. Bamfo, Chelsea Hosey-Cojocari, Leslie Z. Benet, and Connie M. Remsberg (Article)

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PharmVar GeneFocus: CYP2C19., Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, José A G Agúndez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, and Andrea Gaedigk (Article)

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Review and Consensus on Pharmacogenomic Testing in Psychiatry., Chad A. Bousman, Susanne A. Bengesser, Katherine J. Aitchison, Azmeraw T. Amare, Harald Aschauer, Bernhard T. Baune, Bahareh Behroozi Asl, Jeffrey R. Bishop, Margit Burmeister, Boris Chaumette, Li-Shiun Chen, Zachary A. Cordner, Jürgen Deckert, Franziska Degenhardt, Lynn E. DeLisi, Lasse Folkersen, James L. Kennedy, Teri E. Klein, Joseph L. McClay, Francis J. McMahon, Richard Musil, Nancy L. Saccone, Katrin Sangkuhl, Robert M. Stowe, Ene-Choo Tan, Arun K. Tiwari, Clement C. Zai, Gwyneth Zai, Jianping Zhang, Andrea Gaedigk, and Daniel J. Müller (Article)

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PharmVar GeneFocus: CYP2B6., Zeruesenay Desta, Ahmed El-Boraie, Li Gong, Andrew A. Somogyi, Volker M. Lauschke, Collet Dandara, Kathrin Klein, Neil A. Miller, Teri E. Klein, Rachel F. Tyndale, Michelle Whirl-Carrillo, and Andrea Gaedigk (Article)

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Too Much of a Good Thing: Defining Antimicrobial Therapeutic Targets to Minimize Toxicity., Kevin J. Downes and Jennifer Goldman (Article)

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Perceived Harm May Be Helpful: Fear of Fluoroquinolone-Associated Adverse Events in Children., Rana El Feghaly and Jennifer Goldman (Editorial)

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Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective., Chance S. Friesen, Sherwin S. Chan, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Iván L Csanaky, and Valentina Shakhnovich (Article)

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Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy., Chance S. Friesen, Chelsea Hosey-Cojocari, Sherwin S. Chan, Iván L. Csanaky, Jonathan B. Wagner, Brooke Sweeney, Alec Friesen, Jason D. Fraser, and Valentina Shakhnovich (Article)

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Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone., Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, and Chonlaphat Sukasem (Article)

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Resolving discordant CYP2D6 genotyping results in Thai subjects: platform limitations and novel haplotypes, Yaowaluck Hongkaew, Wendy Y. Wang, R Gaedigk, Chonlaphat Sukasem, and Andrea Gaedigk (Article)

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DNA methylation perturbations may link altered development and aging in the lung., Priyadarshini Kachroo, Jarrett D. Morrow, Carrie A. Vyhlidal, R Gaedigk, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, and Dawn L. DeMeo (Article)

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update., Jason H. Karnes, Allan E. Rettie, Andrew A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, Adrian Llerena, Michelle Whirl-Carrillo, Teri E. Klein, Elizabeth J. Phillips, Scott Mintzer, Andrea Gaedigk, Kelly E. Caudle, and John T. Callaghan (Article)

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C19 and Proton Pump Inhibitor Dosing., John J. Lima, Cameron D. Thomas, Julia Barbarino, Zeruesenay Desta, Sara L. Van Driest, Nihal El Rouby, Julie A. Johnson, Larisa H. Cavallari, Valentina Shakhnovich, David L. Thacker, Stuart A. Scott, Matthias Schwab, Chakradhara Rao S Uppugunduri, Christine M. Formea, James P. Franciosi, Katrin Sangkuhl, Andrea Gaedigk, Teri E. Klein, Roseann S. Gammal, and Takahisa Furuta (Article)

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The effect of race and supplementation on maternal and umbilical cord plasma folates., Devika Maulik, Leon van Haandel, Jenifer Allsworth, Kris S Chaisanguanthum, John D Yeast, and J Steven Leeder (Article)

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CYP2D6 Genetic Variation and Its Implication for Vivax Malaria Treatment in Madagascar, Rajeev K. Mehlotra, Andrea Gaedigk, Rosalind E. Howes, Tovonahary A. Rakotomanga, Arsene C. Ratsimbasoa, and Peter A. Zimmerman (Article)

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Trimethoprim-Sulfamethoxazole-associated Fulminant Respiratory Failure in Children and Young Adults., Jenna Miller, Angela R. Shih, Mari Mino-Kenudson, Martin S. Taylor, and Jennifer Goldman (Article)

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Utilization of the Naranjo scale to evaluate adverse drug reactions at a free-standing children's hospital., Madhavi Murali, Sarah Suppes, Keith Feldman, and Jennifer Goldman (Article)

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Genetic variability of CYP2D6, CYP3A4 and CYP3A5 among the Egyptian population, Thuraya M. Mutawi, Mohamed M. Zedan, Raida S. Yahya, Mahmoud M. Zakria, Mamdouh R. El-Sawi, and Andrea Gaedigk (Article)

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Retrospective Review of Pharmacogenetic Testing at an Academic Children's Hospital., Timothy A. Roberts, Jennifer A. Wagner, Tracy L. Sandritter, Benjamin T. Black, Andrea Gaedigk, and Stephani L. Stancil (Article)

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Adolescent perceptions of pharmacogenetic testing., Stephani L. Stancil, Courtney D. Berrios, and Susan M. Abdel-Rahman (Article)

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Profiling Pretomanid as a Therapeutic Option for TB Infection: Evidence to Date., Stephani L. Stancil, Fuad Mirzayev, and Susan M. Abdel-Rahman (Article)

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Neurodevelopmental outcomes in preterm infants with retinopathy of prematurity., Hao Tan, Patricia Blasco, Tamorah R. Lewis, Susan Ostmo, Michael F. Chiang, and John Peter Campbell (Article)

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Ontogeny of Drug-Metabolizing Enzymes., Aarzoo Thakur, Md Masud Parvez, J Steven Leeder, and Bhagwat Prasad (Article)

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Evaluating and Mitigating Risk of Acute Kidney Injury with the Combination of Vancomycin and Piperacillin-Tazobactam in Children., Emma M. Tillman and Jennifer Goldman (Article)

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Enhancing Pediatric Adverse Drug Reaction Documentation in the Electronic Medical Record., Emma M Tillman, Sarah Suppes, Keith Feldman, and Jennifer Goldman (Article)

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Identification of CYP2D6 Haplotypes that Interfere with Commonly Used Assays for Copy Number Variation Characterization., Amy J. Turner, Praful Aggarwal, Erin C. Boone, Cyrine-Eliana Haidar, Mary V. Relling, Ashley D Derezinski, Ulrich Broeckel, and Andrea Gaedigk (Article)

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Loss of Consciousness in the Young Child., Juan Villafane, Jacob R. Miller, Julie Glickstein, Jonathan N Johnson, Jonathan B. Wagner, Chris S. Snyder, Tatiana Filina, Scott L. Pomeroy, S Kristen Sexson-Tejtel, Caitlin Haxel, Jason Gottlieb, Pirooz Eghtesady, and Devyani Chowdhury (Article)

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Effect of Crohn's Disease on Villous Length and CYP3A4 Expression in the Pediatric Small Intestine., Carrie A. Vyhlidal, Brian D. Chapron, Atif Ahmed, Vivekanand Singh, Rebecca Casini, and Valentina Shakhnovich (Article)

Works from 2020

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Severe cutaneous adverse reactions: comparing outcomes in children with and without complex chronic conditions., James W Antoon, Jennifer Goldman, and Brian R. Lee (Article)

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Long-Distance Phasing of a Tentative "Enhancer" Single-Nucleotide Polymorphism With YP2D6 Star Allele Definitions, Erin C. Boone, Wendy Y. Wang, R Gaedigk, Mariana Cherner, Anick Bérard, J Steven Leeder, Neil A. Miller, and Andrea Gaedigk (Article)

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A Moving Target-Vancomycin Therapeutic Monitoring, Alaina N. Burns and Jennifer Goldman (Article)

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CYP2D6 Predicts Plasma Donepezil Concentrations in a Cohort of Thai Patients with Mild to Moderate Dementia., Monpat Chamnanphon, Sorawit Wainipitapong, Teeravut Wiwattarangkul, Phenphichcha Chuchuen, Kunathip Nissaipan, Weeraya Phaisal, Sookjaroen Tangwongchai, Chonlaphat Sukasem, Supeecha Wittayalertpanya, Andrea Gaedigk, Daruj Aniwattanapong, and Pajaree Chariyavilaskul (Article)

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The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites., Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk, and J Steven Leeder (Article)

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Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities., Jean C. Dinh, Chelsea Hosey-Cojocari, and Bridgette Jones (Article)

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Developmental Expression of SULT1C4 Transcript Variants in Human Liver: Implications for Discordance Between SULT1C4 mRNA and Protein Levels., Sarah Dubaisi, Hailin Fang, Joseph A. Caruso, R Gaedigk, Carrie A. Vyhlidal, Thomas A. Kocarek, and Melissa Runge-Morris (Article)

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Use of telemedicine to provide clinical pharmacy services during the SARS-CoV-2 pandemic., Claire Elson, Christopher M. Oermann, Stephanie Duehlmeyer, and Sarah Bledsoe (Letter to the Editor)

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Foundational health content in environmental studies, sciences, and sustainability education: report of a workshop, Elizabeth Friedman, Sasha Adkins, and Tee L. Guidotti (Article)

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PharmVar and the Landscape of Pharmacogenetic Resources., Andrea Gaedigk, Michelle Whirl-Carrillo, Victoria M. Pratt, Neil A. Miller, and Teri E. Klein (Article)

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A Call for Clear and Consistent Communications Regarding the Role of Pharmacogenetics in Antidepressant Pharmacotherapy., J Kevin Hicks, Jeffrey R. Bishop, Roseann S. Gammal, Katrin Sangkuhl, Chad A. Bousman, J Steven Leeder, Adrián Llerena, Daniel J. Mueller, Laura B. Ramsey, Stuart A. Scott, Todd C. Skaar, Kelly E. Caudle, Teri E. Klein, and Andrea Gaedigk (Article)

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Population Pharmacokinetic Modeling of Acetaminophen Protein Adducts in Adults and Children., Sibo Jiang, Kumpal Madrasi, Tanay Samant, Chakradhar Lagishetty, Valvanera Vozmediano, Angela Chiew, Susan M. Abdel-Rahman, Laura P. James, and Stephan Schmidt (Article)

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Co-methylation analysis in lung tissue identifies pathways for fetal origins of COPD., Priyadarshini Kachroo, Jarrett D. Morrow, Alvin T. Kho, Carrie A. Vyhlidal, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, and Dawn L. DeMeo (Article)

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Transfer learning enables prediction of CYP2D6 haplotype function., Gregory McInnes, Rachel Dalton, Katrin Sangkuhl, Michelle Whirl-Carrillo, Seung-Been Lee, Philip S. Tsao, Andrea Gaedigk, Russ B. Altman, and Erica L. Woodahl (Article)

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Serum amoxicillin levels in young infants (0-59 days) with sepsis treated with oral amoxicillin., Fatima Mir, Robin E. Pearce, Naila Baig-Ansari, Shamim Qazi, Jeffrey S Barrett, Susan M. Abdel-Rahman, Greg Kearns, and Anita Km Zaidi (Article)

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Comment on "Transition to two-bag intravenous acetylcysteine for acetaminophen overdose"., Michael E Mullins, Mark C Yarema, Marco L A Sivilotti, Margaret Thompson, Michael C Beuhler, D Adam Algren, and Christopher P Holstege (Response or Comment)

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Screening trimethoprim primary metabolites for covalent binding to albumin, Whitney M. Nolte, Robert T. Tessman, and Jennifer Goldman (Article)

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Filling the Gap in Knowledge for Drug Dose Individualization in Pediatric Obesity., Valentina Shakhnovich and Kathyrn Kyler (Response or Comment)

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Effect of Intrauterine Smoke Exposure on microRNA-15a Expression in Human Lung Development and Subsequent Asthma Risk., Sunita Sharma, Alvin T. Kho, Divya Chhabra, Kathleen Haley, Carrie A. Vyhlidal, R Gaedigk, J Steven Leeder, Kelan G. Tantisira, Benjamin Raby, and Scott T. Weiss (Article)

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Interaction of Oatp1b2 expression and nonalcoholic steatohepatitis on pravastatin plasma clearance., Erica L. Toth, John D. Clarke, Iván L Csanaky, and Nathan J. Cherrington (Article)

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Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Leon Van Haandel, and J Steven Leeder (Article)

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Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport., Jonathan B. Wagner, Melissa Ruggiero, J Steven Leeder, and Bruno Hagenbuch (Article)

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Ontogeny Related Changes in the Pediatric Liver Metabolome., Christopher M. Wilson, Qian Li, R Gaedigk, Chengpeng Bi, Saskia N. de Wildt, J Steven Leeder, and Brooke L. Fridley (Article)

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Normalized Testosterone Glucuronide as a Potential Urinary Biomarker for Highly Variable UGT2B17 in Children 7-18 Years., Haeyoung Zhang, Abdul Basit, Chris Wolford, Kuan-Fu Chen, Andrea Gaedigk, Yvonne S Lin, J Steven Leeder, and Bhagwat Prasad (Article)

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Effects of ablation and activation of Nrf2 on bile acid homeostasis in male mice., Youcai Zhang, Andrew J. Lickteig, Jing Liu, Iván L Csanaky, and Curtis D. Klaassen (Article)

Works from 2019

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Facilitating Informed Permission/Assent/Consent in Pediatric Clinical Trials., Susan M. Abdel-Rahman (Article)

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Cardiovascular benefits of tyrosol and its endogenous conversion into hydroxytyrosol in humans. A randomized, controlled trial., Anna Boronat, Julian Mateus, Natalia Soldevila-Domenech, Mercè Guerra, Jose Rodríguez-Morató, Carlota Varon, Daniel Muñoz, Francina Barbosa, Juan Carlos Morales, Andrea Gaedigk, Klaus Langohr, Maria-Isabel Covas, Clara Pérez-Mañá, Montserrat Fitó, Rachel F. Tyndale, and Rafael de la Torre (Article)

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Data on the endogenous conversion of tyrosol into hydroxytyrosol in humans., Anna Boronat, Julian Mateus, Natalia Soldevila-Domenech, Mercè Guerra, Jose Rodríguez-Morató, Carlota Varon, Daniel Muñoz, Francina Barbosa, Juan Carlos Morales, Andrea Gaedigk, Klaus Langohr, Maria-Isabel Covas, Clara Pérez-Mañá, Montserrat Fitó, Rachel F. Tyndale, and Rafael de la Torre (Article)

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Structural variation at the CYP2C locus: Characterization of deletion and duplication alleles., Mariana R. Botton, Xingwu Lu, Geping Zhao, Elena Repnikova, Yoshinori Seki, Andrea Gaedigk, Eric E. Schadt, Lisa Edelmann, and Stuart A. Scott (Article)

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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy., Jacob T. Brown, Jeffrey R. Bishop, Katrin Sangkuhl, Erika L. Nurmi, Daniel J. Mueller, Jean C. Dinh, Andrea Gaedigk, Teri E. Klein, Kelly E. Caudle, James T. McCracken, Jose de Leon, and J Steven Leeder (Article)

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Improving Recognition and Reporting of Adverse Drug Reactions in the NICU: A Quality Improvement Project., Betsy Cammack, Alexandra Oschman, and Tamorah R. Lewis MD PhD (Article)

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Opioid Prescribing Practices in Pediatric Acute Care Settings., Michelle DePhillips, Jennifer Watts, Jennifer Lowry, and M Denise Dowd (Article)

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Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2B6 and Efavirenz-Containing Antiretroviral Therapy., Zeruesenay Desta, Roseann S. Gammal, Li Gong, Michelle Whirl-Carrillo, Aditya H. Gaur, Chonlaphat Sukasem, Jennifer Hockings, Alan Myers, Marelize Swart, Rachel F. Tyndale, Collen Masimirembwa, Otito F. Iwuchukwu, Sanika Chirwa, Jeffrey Lennox, Andrea Gaedigk, Teri E. Klein, and David W. Haas (Article)

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Pharmacology of Common Analgesic and Sedative Drugs Used in the Neonatal Intensive Care Unit., Jamesia Donato, Karishma Rao, and Tamorah R. Lewis MD PhD (Article)

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Developmental Expression of the Cytosolic Sulfotransferases in Human Liver., Sarah Dubaisi, Joseph A. Caruso, R Gaedigk, Carrie A. Vyhlidal, Philip C. Smith, Ronald N. Hines, Thomas A. Kocarek, and Melissa Runge-Morris (Article)

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Pharmacogenetics: Chasing Perfection., Andrea Gaedigk (Editorial)

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Characterization of Reference Materials for Genetic Testing of CYP2D6 Alleles: A GeT-RM Collaborative Project., Andrea Gaedigk, Amy Turner, Robin E. Everts, Stuart A. Scott, Praful Aggarwal, Ulrich Broeckel, Gwendolyn A. McMillin, Roberta Melis, Erin C. Boone, Victoria M. Pratt, and Lisa V. Kalman (Article)

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The Case for Pharmacogenetics-Guided Prescribing of Codeine in Children., Roseann S. Gammal, Kelly E. Caudle, Charles T. Quinn, Winfred C. Wang, Andrea Gaedigk, Cynthia A. Prows, Cyrine E. Haidar, Annette K. Taylor, Teri E. Klein, Katrin Sangkuhl, Jane S. Hankins, and Kristine R. Crews (Article)

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Adverse drug reaction causality assessment tools for drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: room for improvement., Jennifer Goldman, Wen-Hung Chung, Brian R. Lee, Chun-Bing Chen, Chun-Wei Lu, Wolfram Hoetzenecker, Robert Micheletti, Sally Usdin Yasuda, David J. Margolis, Neil H. Shear, Jeffery P. Struewing, and Munir Pirmohamed (Article)

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Population pharmacokinetics of sildenafil in extremely premature infants., Daniel Gonzalez, Matthew M. Laughon, P Brian Smith, Shufan Ge, Namasivayam Ambalavanan, Andrew Atz, Gregory M. Sokol, Chi D. Hornik, Dan Stewart, Gratias Mundakel, Brenda B. Poindexter, R Gaedigk, Mary Mills, Michael Cohen-Wolkowiez, Karen Martz, Christoph P. Hornik, and Best Pharmaceuticals for Children Act - Pediatric Trials Network Steering Committee (Article)

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Acetaminophen Protein Adducts in Hospitalized Children Receiving Multiple Doses of Acetaminophen., Sibo Jiang, Valvanera Vozmediano, Susan M. Abdel-Rahman, Stephan Schmidt, and Laura P. James (Article)

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Drug Dose Selection in Pediatric Obesity: Available Information for the Most Commonly Prescribed Drugs to Children, Kathyrn Kyler, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Kevin Watt, and Valentina Shakhnovich (Article)

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Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism., Mayur K. Ladumor, Deepak Kumar Bhatt, Andrea Gaedigk, Sheena Sharma, Aarzoo Thakur, Robin E. Pearce, J Steven Leeder, Michael B. Bolger, Saranjit Singh, and Bhagwat Prasad (Article)

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Who Believes They Are "Just Average": Informing the Treatment of Individual Patients Using Population Data., J Steven Leeder (Article)

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Optimized Renal Transporter Quantification by Using Aquaporin 1 and Aquaporin 2 as Anatomical Markers: Application in Characterizing the Ontogeny of Renal Transporters and Its Correlation with Hepatic Transporters in Paired Human Samples., Cindy Yanfei Li, Chelsea Hosey-Cojocari, Abdul Basit, Jashvant D Unadkat, J Steven Leeder, and Bhagwat Prasad (Article)

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Effects of Absence of Constitutive Androstane Receptor (CAR) on Bile Acid Homeostasis in Male and Female Mice., Andrew J. Lickteig, Youcai Zhang, Curtis D. Klaassen, and Iván L. Csanaky (Article)

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Examining the role of precision medicine with oral baclofen in pediatric patients with cerebral palsy., Matthew J. McLaughlin, Susan M. Abdel-Rahman, and J Steven Leeder (Article)

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Considerations for Implementing Precision Therapeutics for Children., Matthew J. McLaughlin, Jonathan B. Wagner, Valentina Shakhnovich, Bruce Carleton, and J Steven Leeder (Article)

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Assessing effectiveness of a novel mid-upper arm circumference Z-score tape in a community setting in Guatemala., Mikaela A. Miller, Kristen Mallory, Manolo Escobedo, Ana Cecilia Tarot, and Susan M. Abdel-Rahman (Article)

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Description of an Innovative Pediatric Individualized Therapeutics Clinic: Working toward Precision Drug Therapy., Tracy L. Sandritter, Jean C. Dinh, Jennifer A. Wagner, and Jennifer Lowry (Article)

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An electronic medical records-based approach to identify idiosyncratic drug-induced liver injury in children., Tracy L. Sandritter, Jennifer Goldman, Clayton J Habiger, James F. Daniel, Jennifer Lowry, and Ryan T. Fischer (Article)

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Visible-Light-Activated High-Density Materials for Controlled in Vivo Insulin Release., Bhagyesh R. Sarode, Karen Kover, and Simon H. Friedman (Article)

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Lean body weight dosing avoids excessive systemic exposure to proton pump inhibitors for children with obesity, Valentina Shakhnovich, Susan M. Abdel-Rahman, Craig A. Friesen, J. Weigel, Robin E. Pearce, Andrea Gaedigk, J Steven Leeder, and G. L. Kearns (Article)

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Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model., Rakesh K. Singh, Leon van Haandel, Paul Kiptoo, Mara L. Becker, Teruna J. Siahaan, and Ryan S. Funk (Article)

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Naltrexone Reduces Binge Eating and Purging in Adolescents in an Eating Disorder Program., Stephani L. Stancil, William P. Adelman, Amanda Dietz, and Susan M. Abdel-Rahman (Article)

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Evaluating metronidazole as a novel, safe CYP2A6 phenotyping probe in healthy adults., Stephani L. Stancil, Robin E. Pearce, Rachel F. Tyndale, Gregory L. Kearns, Carrie A. Vyhlidal, J Steven Leeder, and Susan M. Abdel-Rahman (Article)

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Children Are Not Small Adults: Specific Findings in Statin Exposure and Response in a Growing Population., Jonathan B. Wagner (Article)

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Genomics and Precision Medicine to Direct Statin Use in the Young., Jonathan B. Wagner (Article)

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Impact of Genetic Variation on Pravastatin Systemic Exposure in Pediatric Hypercholesterolemia., Jonathan B. Wagner, Susan M. Abdel-Rahman, R Gaedigk, Andrea Gaedigk, Geetha Raghuveer, Vincent S. Staggs, Ralph Kauffman, Leon Van Haandel, and J Steven Leeder (Article)

Works from 2018

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Variability of surgical prophylaxis in penicillin-allergic children., David F. Butler, Brian R. Lee, Sarah Suppes, Tracy Sandritter, Jason G. Newland, Lory Harte, and Jennifer Goldman (Article)

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Hydroxycarbamide in children with sickle cell anaemia after first-dose vs. chronic therapy: pharmacokinetics and predictive models for drug exposure., Jeremie H. Estepp, Paweł Wiczling, Joseph Moen, Guolian Kang, Joana Marie Mack, Robert Liem, Julie A. Panepinto, Uttam Garg, Gregory Kearns, and Kathleen A. Neville (Article)

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Intensive and prolonged urine collection in preterm infants reveals three distinct indomethacin metabolic patterns: potential implications for drug dosing., Tamorah R. Lewis, Leon Van Haandel, Allison Scott, and J Steven Leeder (Response or Comment)

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It's Time to Reverse our Thinking: The Reverse Translation Research Paradigm, Valentina Shakhnovich (Editorial)

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A Population-Based Pharmacokinetic Model Approach to Pantoprazole Dosing for Obese Children and Adolescents, Valentina Shakhnovich, P. Brian Smith, Jeffrey T. Guptill, Laura P. James, David N. Collier, Huali Wu, Chad E. Livingston, Jian Zhao, Gregory L. Kearns, and Michael Cohen-Wolkowiez (Article)

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Reply, Valentina Shakhnovich, P. Brian Smith, Huali Wu, Michael Cohen-Wolkowiez, and Gregory L. Kearns (Letter to the Editor)

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Development of a UPLC-MS/MS method for quantitation of metronidazole and 2-hydroxy metronidazole in human plasma and its application to a pharmacokinetic study., Stephani L. Stancil, Leon van Haandel, Susan M. Abdel-Rahman, and Robin E. Pearce (Article)

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Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants., Bianca D. van Groen, Evita van de Steeg, Miriam G. Mooij, Marola M H van Lipzig, Barbara A E de Koning, Robert M. Verdijk, Heleen M. Wortelboer, R Gaedigk, Chengpeng Bi, J Steven Leeder, Ron H N van Schaik, Joost van Rosmalen, Dick Tibboel, Wouter H. Vaes, and Saskia N. de Wildt (Article)

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Impact of SLCO1B1 Genotype on Pediatric Simvastatin Acid Pharmacokinetics., Jonathan B. Wagner, Susan M. Abdel-Rahman, Leon Van Haandel, Andrea Gaedigk, R Gaedigk, Geetha Raghuveer, Ralph Kauffman, and J Steven Leeder (Article)

Works from 2017

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Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants., Mikael Boberg, Marc Vrana, Aanchal Mehrotra, Robin E. Pearce, Andrea Gaedigk, Deepak Kumar Bhatt, J Steven Leeder, and Bhagwat Prasad (Article)

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A comparison of 7-day versus 10-day course of low-dose dexamethasone for chronically ventilated preterm infants., Alain Cuna, S Govindarajan, Alexandra Oschman, H Dai, K Brophy, Michael Norberg, and William E. Truog (Article)