Works from 2024
The Effect of Udenafil on Heart Rate and Blood Pressure in Adolescents With the Fontan Circulation., Jonathan B. Edelson, Victor Zak, David Goldberg, Greg Fleming, Andrew S. Mackie, Jyoti K. Patel, Matthew Files, Tacy Downing, Marc Richmond, Ben Acheampong, Mark Cartoski, Jon Detterich, Brian McCrindle, Kimberly McHugh, Jesse E. Hansen, Jonathan B. Wagner, Michael Di Maria, Angela Weingarten, Todd Nowlen, Ja Kyoung Yoon, Gi Beom Kim, Richard Williams, Robert Whitehill, Edward Kirkpatrick, Suellen Yin, Peter Ermis, Adam M. Lubert, Mario Stylianou, D'Andrea Freemon, Chenwei Hu, Olukayode D. Garuba, Peter Frommelt, Bryan H. Goldstein, Stephen Paridon, Ruchira Garg, and Pediatric Heart Network Investigators (Article)
Clarification of adverse drug reactions by a pharmacovigilance team results in increased antibiotic re-prescribing at a freestanding United States children's hospital., Keith Feldman, Sarah Suppes, and Jennifer Goldman (Article)
Response to "DPYD genotyping panels: Impact of population diversity"., Andrea Gaedigk, Amy J. Turner, Cyrine E. Haidar, Philip E. Empey, and Steven M. Offer (Response or Comment)
Pharmacogenetic Factors Influence Escitalopram Pharmacokinetics and Adverse Events in Youth with a Family History of Bipolar Disorder: A Preliminary Study., Duncan C. Honeycutt, Thomas J. Blom, Laura Ramsey, Jeffrey R. Strawn, Kaitlyn M. Bruns, Jeffrey A. Welge, Luis R. Patino, Manpreet K. Singh, and Melissa P. DelBello (Article)
Hearing the Unheard: Voices of Black Emerging Adults With Uncontrolled Asthma., Bridgette Jones and Mahesh Padukudru Anand (Editorial)
Influence of CYP2D6 Metabolizer Status on Risperidone and Paliperidone Tolerability in Children and Adolescents., Amarachi A. Kanu, Michelle M. Johnston, Ethan A. Poweleit, Samuel E. Vaughn, Jeffrey R. Strawn, and Laura Ramsey (Article)
Machine Learning-Based Prediction of Escitalopram and Sertraline Side Effects With Pharmacokinetic Data in Children and Adolescents., Ethan A. Poweleit, Samuel E. Vaughn, Zeruesenay Desta, Judith W. Dexheimer, Jeffrey R. Strawn, and Laura Ramsey (Article)
The impact of skin color and tone on histamine iontophoresis and Doppler flowmetry measurements as a pharmacodynamic biomarker., Aarya Ramprasad, Adara Ezekwe, Brian R. Lee, Shiva Balasubramanian, and Bridgette Jones (Article)
Pharmacogenetics and Oxcarbazepine in Children and Adolescents: Beyond HLA-B*15:02, Stephani L. Stancil, Tracy L. Sandritter, and Jeffrey R. Strawn (Article)
Opportunities for Pharmacogenetic Testing to Guide Dosing of Medications in Youths With Medicaid., Sonya Tang Girdwood, Matthew Hall, James W. Antoon, Kathryn Kyler, Derek J. Williams, Samir S. Shah, Lucas E. Orth, Jennifer Goldman, James A. Feinstein, and Laura B. Ramsey (Article)
Updated DPYD HapB3 haplotype structure and implications for pharmacogenomic testing., Amy J. Turner, Cyrine E. Haidar, Wenjian Yang, Erin C. Boone, Steven M. Offer, Philip E. Empey, Andrew Haddad, Saba Tahir, Gunter Scharer, Ulrich Broeckel, and Andrea Gaedigk (Article)
SLCO1B1 Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia, Jonathan B. Wagner, Susan Abdel-Rahman, Geetha Raghuveer, Andrea Gaedigk, Erin C. Boone, Roger Gaedigk, Vincent S. Staggs, Gregory A. Reed, Na Zhang, and J Steven Leeder (Article)
Pediatric Beta Blocker Therapy: A Comprehensive Review of Development and Genetic Variation to Guide Precision-Based Therapy in Children, Adolescents, and Young Adults., Mollie Walton and Jonathan B. Wagner (Article)
Response to "What is the Current Clinical Impact of the CYP2C:TG Haplotype?"., Pablo Zubiaur, J Steven Leeder, Francisco Abad-Santos, and Andrea Gaedigk (Response or Comment)
Works from 2023
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6, CYP2C19, CYP2B6, SLC6A4, and HTR2A Genotypes and Serotonin Reuptake Inhibitor Antidepressants., Chad A. Bousman, James M. Stevenson, Laura B. Ramsey, Katrin Sangkuhl, J Kevin Hicks, Jeffrey R. Strawn, Ajeet B. Singh, Gualberto Ruaño, Daniel J. Mueller, Evangelia Eirini Tsermpini, Jacob T. Brown, Gillian C. Bell, J Steven Leeder, Andrea Gaedigk, Stuart A. Scott, Teri E. Klein, Kelly E. Caudle, and Jeffrey R. Bishop (Article)
Evaluating treatment outcomes in pharmacogenomic-guided care for major depression: A rapid review and meta-analysis., Mary Bunka, Gavin Wong, Dan Kim, Louisa Edwards, Jehannine Austin, Mary M. Doyle-Waters, Andrea Gaedigk, and Stirling Bryan (Article)
Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism., Estee Y. Cramer, Jacquelaine Bartlett, Ernest R. Chan, Andrea Gaedigk, Arsene C. Ratsimbasoa, Rajeev K. Mehlotra, Scott M. Williams, and Peter A. Zimmerman (Article)
Standardization of Fertility Preservation Discussion Among Pediatric Oncology and Bone Marrow Transplant Patients: A Single Institution Experience., Chandni Dargan, Sarah Mc Dermott, Shelby Chesbro, Amanda Trout, Nancy Terwilliger, Tennille Hilyard, Ashley Flynn, and Joy M. Fulbright (Article)
Characterization of Reference Materials for CYP3A4 and CYP3A5: A (GeT-RM) Collaborative Project., Andrea Gaedigk, Erin C. Boone, Amy J. Turner, Ron H N van Schaik, Dilyara Chernova, Wendy Y. Wang, Ulrich Broeckel, Caitlin A. Granfield, Jennelle C. Hodge, Reynold C. Ly, Ty C. Lynnes, Matthew W. Mitchell, Ann M. Moyer, Jason Oliva, and Lisa V. Kalman (Article)
Identifying Effective Treatments for Dystonia in Patients With Cerebral Palsy: A Precision Therapeutics Approach., Rose N. Gelineau-Morel, Christopher Smyser, and J Steven Leeder (Article)
The Fontan Udenafil Exercise Longitudinal Trial: Subgroup Analysis., David J. Goldberg, Chenwei Hu, Adam M. Lubert, Rahul H. Rathod, Daniel J. Penny, Christopher J. Petit, Kurt R. Schumacher, Salil Ginde, Richard V. Williams, J K Yoon, Gi Beom Kim, Todd T. Nowlen, Michael V. DiMaria, Benjamin P. Frischhertz, Jonathan B. Wagner, Kimberly E. McHugh, Brian W. McCrindle, Mark J. Cartoski, Jon A. Detterich, Anji T. Yetman, Anitha S. John, Marc E. Richmond, Delphine Yung, R Mark Payne, Andrew S. Mackie, Christopher K. Davis, Shabana Shahanavaz, Kevin D. Hill, Marisa Almaguer, Victor Zak, Michael G. McBride, Bryan H. Goldstein, Gail D. Pearson, Stephen M. Paridon, and Pediatric Heart Network Investigators (Article)
Pharmacogenetic Testing in Patients with Autism Spectrum Disorder Evaluated in a Precision Medicine Clinic., Rachel Goodson, Jennifer Wagner, Tracy L. Sandritter, Vincent S. Staggs, Sarah E. Soden, and Cy Nadler (Article)
Committing to genomic answers for all kids: Evaluating inequity in genomic research enrollment., Natalie J. Kane, Ana S A Cohen, Courtney D. Berrios, Bridgette Jones, T Pastinen, and Mark A. Hoffman (Article)
Advancing CYP2D6 Pharmacogenetics through a Pharmacoequity Lens., Oyinlade Kehinde, Laura B. Ramsey, Andrea Gaedigk, and Akinyemi Oni-Orisan (Article)
Peak Oxygen Consumption (V̇O 2peak ) Recovery Delay in a Pediatric Fontan Population., Karoline Krzywda, Kelli M. Teson, Jessica S. Watson, Suma Goudar, Daniel Forsha, Jonathan B. Wagner, and David A. White (Article)
Developmental pharmacokinetics of indomethacin in preterm neonates: Severely decreased drug clearance in the first week of life., Wojciech Krzyzanski, Bradley Stockard, Andrea Gaedigk, Allison Scott, Whitney M. Nolte, Kim T. Gibson, J Steven Leeder, and Tamorah Lewis (Article)
The chicken or the egg: The role of IL-6 in pediatric obese and allergen-exposed asthma., Kathyrn Kyler and Bridgette Jones (Editorial)
Multidisciplinary Approach to Deciphering Etoposide Infusion Reactions and Potential Role of Polyethersulfone Filter Membranes., Nicholas Miles, Andi Masters, Zeruesenay Desta, Jennifer Goldman, Sarah Suppes, and Emma M. Tillman (Article)
Case report: Use of therapeutic drug monitoring and pharmacogenetic testing as opportunities to individualize care in a case of flecainide toxicity after fetal supraventricular tachycardia., Ronald Palmen, Tracy L. Sandritter, Lindsey Malloy-Walton, Christopher Follansbee, and Jonathan B. Wagner (Article)
CYP3A4 and CYP3A5 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase., Victoria M. Pratt, Larisa H. Cavallari, Makenzie L. Fulmer, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa V. Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, Ron H N van Schaik, Michelle Whirl-Carrillo, and Karen E. Weck (Article)
PharmVar GeneFocus: SLCO1B1., Laura B. Ramsey, Li Gong, Seung-Been Lee, Jonathan B. Wagner, Xujia Zhou, Katrin Sangkuhl, Solomon M. Adams, Robert J. Straka, Philip E. Empey, Erin C. Boone, Teri E. Klein, Mikko Niemi, and Andrea Gaedigk (Article)
Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug-Gene Pairs to Know., Tracy L. Sandritter, Rachel Chevalier, Rebecca Abt, and Valentina Shakhnovich (Article)
A longitudinal analysis of the effect of anemia on executive functions in children with mild to moderate chronic kidney disease., Nisha S. Singh, Rebecca J. Johnson, Matthew B. Matheson, Joann Carlson, Stephen R. Hooper, and Bradley A. Warady (Article)
Ontogeny of Scaling Factors for Pediatric Physiologically Based Pharmacokinetic Modeling and Simulation: Cytosolic Protein Per Gram of Liver., Stephani L. Stancil, Robin E. Pearce, Vincent S. Staggs, and J Steven Leeder (Article)
Characterization of complex structural variation in the CYP2D6-CYP2D7-CYP2D8 gene loci using single-molecule long-read sequencing, Amy J. Turner, Ashley D. Derezinski, Andrea Gaedigk, Mark E. Berres, David B. Gregornik, Keith Brown, Ulrich Broeckel, and Gunter Scharer (Article)
PharmVar Tutorial on CYP2D6 Structural Variation Testing and Recommendations on Reporting., Amy J. Turner, Charity Nofziger, Bronwyn E. Ramey, Reynold C. Ly, Chad A. Bousman, José A G Agúndez, Katrin Sangkuhl, Michelle Whirl-Carrillo, Simone Vanoni, Henry M. Dunnenberger, Gualberto Ruaño, Martin A. Kennedy, Michael S. Phillips, Houda Hachad, Teri E. Klein, Ann M. Moyer, and Andrea Gaedigk (Article)
Novel expansion of a well-established antimicrobial stewardship program: Enhancing program efficiency and reach., Ann L. Wirtz, Brian R. Lee, Alaina N. Burns, Ryan McDonough, Tammy Frank, Darrell E. Hall, Kate Vanlandingham, and Jennifer Goldman (Article)
Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity., Pablo Zubiaur, Paula Soria-Chacartegui, Erin C. Boone, Bhagwat Prasad, Jean Dinh, Wendy Y. Wang, Santiago Zugbi, Andrea Rodríguez-Lopez, Eva González-Iglesias, J Steven Leeder, Francisco Abad-Santos, and Andrea Gaedigk (Article)
Works from 2022
Interindividual Variability and Differential Tissue Abundance of Mitochondrial Amidoxime Reducing Component Enzymes in Humans., Deepak Ahire, Abdul Basit, Lisa J. Christopher, Ramaswamy Iyer, J Steven Leeder, and Bhagwat Prasad (Article)
Isolation and Identification of 3,4-Seco-Solanidine-3,4-dioic acid (SSDA) as a Urinary Biomarker of Cytochrome P450 2D6 (CYP2D6) Activity., Andrew C. Behrle, Justin Douglas, J Steven Leeder, and Leon van Haandel (Article)
Parental understanding and attitudes following pharmacogenomic testing for pediatric neuropsychiatric patients., Courtney D. Berrios, Sophia K. Sadaro, Tracy L. Sandritter, Jennifer A. Wagner, Sarah E. Soden, Benjamin Black, and Susan Abdel-Rahman (Article)
CYP2D6 gene resequencing in the Malagasy, a population at the crossroads between Asia and Africa: a pilot study, E Ricky Chan, Rajeev K. Mehlotra, Karim A Pirani, Arsene C. Ratsimbasoa, Scott M. Williams, Andrea Gaedigk, and Peter A. Zimmerman (Article)
Recent advances in the ontogeny of drug disposition., Brian D. Chapron, Alenka Chapron, and J Steven Leeder (Article)
Clinical Implications of Altered Drug Transporter Abundance/Function and PBPK Modeling in Specific Populations: An ITC Perspective., Xiaoyan Chu, Bhagwat Prasad, Sibylle Neuhoff, Kenta Yoshida, J Steven Leeder, Dwaipayan Mukherjee, Kunal Taskar, Manthena V S Varma, Xinyuan Zhang, Xinning Yang, and Aleksandra Galetin (Article)
The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity., Jean C. Dinh, Erin C. Boone, Vincent S. Staggs, Robin E. Pearce, Wendy Y. Wang, Roger Gaedigk, J Steven Leeder, and Andrea Gaedigk (Article)
Novel Oncogenic PDGFRB Variant in Severe Infantile Myofibromatosis With Response to Imatinib Using Therapeutic Drug Monitoring, Abbey Elsbernd, Boutaina Boulouadnine, Atif Ahmed, Midhat S. Farooqi, Tracy L. Sandritter, Valentina Shakhnovich, Darius Blanding, Jean-Baptiste Demoulin, and Joel Thompson (Article)
Utility of the 13C-pantoprazole breath test as a CYP2C19 phenotyping probe for children, Keith Feldman, Gregory L. Kearns, Robin E. Pearce, Susan M. Abdel-Rahman, J Steven Leeder, Alec Friesen, Vincent S. Staggs, Andrea Gaedigk, Jaylene Weigel, and Valentina Shakhnovich (Article)
CYP2C8, CYP2C9, and CYP2C19 Characterization Using Next-Generation Sequencing and Haplotype Analysis: A GeT-RM Collaborative Project., Andrea Gaedigk, Erin C. Boone, Steven E. Scherer, Seung-Been Lee, Ibrahim Numanagić, Cenk Sahinalp, Joshua D. Smith, Sean McGee, Aparna Radhakrishnan, Xiang Qin, Wendy Y. Wang, Emily G. Farrow, Nina Gonzaludo, Aaron L. Halpern, Deborah A. Nickerson, Neil A. Miller, Victoria M. Pratt, and Lisa V. Kalman (Article)
A cross-sectional study of the relationship between CYP2D6 and CYP2C19 variations and depression symptoms, for women taking SSRIs during pregnancy., Catriona Hippman, Caitlin Slomp, Emily Morris, Rolan Batallones, Angela Inglis, Prescilla Carrion, Ursula Brain, Michelle Higginson, Galen E B Wright, Lynda G. Balneaves, Deirdre Ryan, Corey Nislow, Colin J D Ross, Andrea Gaedigk, Tim F. Oberlander, and Jehannine Austin (Article)
Pediatric growth patterns in youth-onset type 2 diabetes mellitus: Implications for physiologically-based pharmacokinetic models., Chelsea M. Hosey, Kelsee Halpin, Valentina Shakhnovich, Chengpeng Bi, Brooke Sweeney, Yun Yan, and J Steven Leeder (Article)
Considering metformin as a second-line treatment for children and adolescents with prediabetes., Chelsea M Hosey, Kelsee Halpin, and Yun Yan (Article)
Ontogeny of Pediatric Pharmacogenetics: Celebrating the Past and Vision for the Future., J Steven Leeder (Article)
Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver., J Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad, and Robin E. Pearce (Article)
A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence., J Steven Leeder, Andrea Gaedigk, Krista J. Wright, Vincent S. Staggs, Sarah E. Soden, Yvonne S. Lin, and Robin E. Pearce (Article)
Dosing Variability and Clinical Outcomes of Oxybutynin: A Pediatric Cohort of Patients With Neurogenic Bladder., Mahnoor F. Malik, Joseph Hogan Randall, Jack G. Campbell, Matthew J. McLaughlin, and Joel F Koenig (Article)
Case Report: Pharmacogenetics Applied to Precision Psychiatry Could Explain the Outcome of a Patient With a New CYP2D6 Genotype, Elena Marcos-Vadillo, Lorena Carrascal-Laso, Ignacio Ramos-Gallego, Andrea Gaedigk, Belén García-Berrocal, Eduardo Mayor-Toranzo, Alfonso Sevillano-Jiménez, Almudena Sánchez, María Isidoro-García, and Manuel Franco-Martín (Article)
Therapeutic plasma exchange for multiorgan dysfunction among critically ill pediatric patients with leukemia: A single-institutional experience., Sarah E. Mc Dermott, Chandni Dargan, Elizabeth Gonzalez, Lejla Music Aplenc, Terrie Flatt, and Nazia Iqbal (Article)
Ten Years of Experience Support Pharmacogenetic Testing to Guide Individualized Drug Therapy., María Celsa Peña-Martín, Belén García-Berrocal, Almudena Sánchez-Martín, Elena Marcos-Vadillo, María Jesús García-Salgado, Santiago Sánchez, Carolina Lorenzo, David González-Parra, Francisco Sans, Manuel Franco, Andrea Gaedigk, María José Mateos-Sexmero, Catalina Sanz, and María Isidoro-García (Article)
TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase., Victoria M. Pratt, Larisa H. Cavallari, Makenzie L. Fulmer, Andrea Gaedigk, Houda Hachad, Yuan Ji, Lisa V. Kalman, Reynold C. Ly, Ann M. Moyer, Stuart A. Scott, R H N van Schaik, Michelle Whirl-Carrillo, and Karen E. Weck (Article)
Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project., Victoria M. Pratt, Wendy Y. Wang, Erin C. Boone, Ulrich Broeckel, Neal Cody, Lisa Edelmann, Andrea Gaedigk, Ty C. Lynnes, Elizabeth B. Medeiros, Ann M. Moyer, Matthew W. Mitchell, Stuart A. Scott, Petr Starostik, Amy Turner, and Lisa V. Kalman (Article)
CYP2D6*9 and *41: Does the Activity Value Assigned to these Alleles Need to be Reduced to more Accurately Predict Phenotype?, Laura B. Ramsey and Andrea Gaedigk (Article)
PharmVar GeneFocus: CYP3A5., Cristina Rodriguez-Antona, Jessica L. Savieo, Volker M. Lauschke, Katrin Sangkuhl, Britt I. Drögemöller, Danxin Wang, Ron H N van Schaik, Andrei A. Gilep, Arul P. Peter, Erin C. Boone, Bronwyn E. Ramey, Teri E. Klein, Michelle Whirl-Carrillo, Victoria M. Pratt, and Andrea Gaedigk (Article)
Ehrlichia-induced hemophagocytic lymphohistiocytosis in a pediatric kidney transplant recipient., Nisha S. Singh, Alexa L. Pagano, J Allyson Hays, Alexander Kats, Steven M. Dahl, Bradley A. Warady, Nathan T. Beins, and Dwight E. Yin (Article)
The Impact of Age and Genetics on Naltrexone Biotransformation., Stephani L. Stancil, Whitney M. Nolte, Robin E. Pearce, Vincent S. Staggs, and J Steven Leeder (Article)
Effects of genotype and food on naltrexone exposure in adolescents., Stephani L. Stancil, Michaela Voss, Whitney M. Nolte, John Tumberger, William Adelman, and Susan Abdel-Rahman (Article)
Pharmacometabolomics Profiling of Preterm Infants Validates Patterns of Metabolism Associated With Response to Dexamethasone Treatment for Bronchopulmonary Dysplasia., Bradley Stockard, Cheri Gauldin, William E. Truog, and Tamorah Lewis (Article)
Influence of CYP2D6 genetic variation on adverse events with propafenone in the pediatric and young adult population., Sudeep D. Sunthankar, Prince J. Kannankeril, Andrea Gaedigk, Andrew E. Radbill, Frank A. Fish, and Sara L. Van Driest (Article)
Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG)., Marwan K. Tayeh, Andrea Gaedigk, Matthew P. Goetz, Teri E. Klein, Elaine Lyon, Gwendolyn A. McMillin, Stefan Rentas, Marwan Shinawi, Victoria M. Pratt, Stuart A. Scott, and ACMG Laboratory Quality Assurance Committee (Article)
Simultaneous quantification of trimethoprim metabolites in pediatric plasma., Robert T. Tessman, Whitney M. Nolte, Paul C. Toren, Kim T. Gibson, Linda Vu, and Jennifer Goldman (Article)
A consensus statement on the use of botulinum toxin in pediatric patients., Joshua A. Vova, Michael M. Green, Joline E. Brandenburg, Loren Davidson, Andrea Paulson, Supreet Deshpande, Joyce L. Oleszek, Didem Inanoglu, and Matthew J. McLaughlin (Article)
Characterization of Novel CYP2D6 Alleles across Sub-Saharan African Populations, Wendy Y. Wang, David Twesigomwe, Charity Nofziger, Amy J. Turner, Lena-Sophie Helmecke, Ulrich Broeckel, Ashley D. Derezinski, Scott Hazelhurst, and Andrea Gaedigk (Article)
The Identification of Novel CYP2D6 Variants in US Hmong: Results From Genome Sequencing and Clinical Genotyping, Ya Feng Wen, Andrea Gaedigk, Erin C. Boone, Wendy Y. Wang, and Robert J. Straka (Article)
Use of pharmacogenetics for benzodiazepine prescription: state of the art and expectations., Pablo Zubiaur and Francisco Abad-Santos (Editorial)
CYP2C18: the orphan in the CYP2C family., Pablo Zubiaur and Andrea Gaedigk (Editorial)
Works from 2021
A Pilot Comparison of High- Versus Low-Tech Palatability Assessment Tools in Young Children., Susan M. Abdel-Rahman, Shasha Bai, Patricia A. Porter-Gill, Grace A. Goode, and Gregory L. Kearns (Article)
Racial and Ethnic Diversity in Studies Funded Under the Best Pharmaceuticals for Children Act., Susan M. Abdel-Rahman, Ian M. Paul, Chi Hornik, Janice E. Sullivan, Kelly Wade, Paula Delmore, Gaurav Sharma, Daniel K. Benjamin, and Kanecia O. Zimmerman (Article)
Editorial: NSAIDs Pharmacogenomics., José A G Agúndez, Christine Formea, Andrea Gaedigk, Elena García-Martín, Li Gong, Tilo Grosser, Craig R. Lee, and Katherine N. Theken (Editorial)
Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans., Nadia O. Bamfo, Chelsea Hosey-Cojocari, Leslie Z. Benet, and Connie M. Remsberg (Article)
PharmVar GeneFocus: CYP2C19., Mariana R. Botton, Michelle Whirl-Carrillo, Andria L. Del Tredici, Katrin Sangkuhl, Larisa H. Cavallari, José A G Agúndez, Jorge Duconge, Ming Ta Michael Lee, Erica L. Woodahl, Karla Claudio-Campos, Ann K. Daly, Teri E. Klein, Victoria M. Pratt, Stuart A. Scott, and Andrea Gaedigk (Article)
Review and Consensus on Pharmacogenomic Testing in Psychiatry., Chad A. Bousman, Susanne A. Bengesser, Katherine J. Aitchison, Azmeraw T. Amare, Harald Aschauer, Bernhard T. Baune, Bahareh Behroozi Asl, Jeffrey R. Bishop, Margit Burmeister, Boris Chaumette, Li-Shiun Chen, Zachary A. Cordner, Jürgen Deckert, Franziska Degenhardt, Lynn E. DeLisi, Lasse Folkersen, James L. Kennedy, Teri E. Klein, Joseph L. McClay, Francis J. McMahon, Richard Musil, Nancy L. Saccone, Katrin Sangkuhl, Robert M. Stowe, Ene-Choo Tan, Arun K. Tiwari, Clement C. Zai, Gwyneth Zai, Jianping Zhang, Andrea Gaedigk, and Daniel J. Müller (Article)
CYP2D6 genotype and reduced codeine analgesic effect in real-world clinical practice., Daniel Carranza-Leon, Alyson L. Dickson, Andrea Gaedigk, C Michael Stein, and Cecilia P. Chung (Article)
Influence of SULT1A1*2 Polymorphism on Plasma Efavirenz Concentration in Thai HIV-1 Patients, Monpat Chamnanphon, Rattanaporn Sukprasong, Andrea Gaedigk, Weerawat Manosuthi, Pajaree Chariyavilaskul, Supeecha Wittayalertpanya, Napatrupron Koomdee, Thawinee Jantararoungtong, Apichaya Puangpetch, and Chonlaphat Sukasem (Article)
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy., Kristine R. Crews, Andrew A. Monte, Rachel Huddart, Kelly E. Caudle, Evan D. Kharasch, Andrea Gaedigk, Henry M. Dunnenberger, J Steven Leeder, John T. Callaghan, Caroline Flora Samer, Teri E. Klein, Cyrine E. Haidar, Sara L. Van Driest, Gualberto Ruano, Katrin Sangkuhl, Larisa H. Cavallari, Daniel J. Müller, Cynthia A. Prows, Mohamed Nagy, Andrew A. Somogyi, and Todd C. Skaar (Article)
PharmVar GeneFocus: CYP2B6., Zeruesenay Desta, Ahmed El-Boraie, Li Gong, Andrew A. Somogyi, Volker M. Lauschke, Collet Dandara, Kathrin Klein, Neil A. Miller, Teri E. Klein, Rachel F. Tyndale, Michelle Whirl-Carrillo, and Andrea Gaedigk (Article)
Too Much of a Good Thing: Defining Antimicrobial Therapeutic Targets to Minimize Toxicity., Kevin J. Downes and Jennifer Goldman (Article)
Perceived Harm May Be Helpful: Fear of Fluoroquinolone-Associated Adverse Events in Children., Rana El Feghaly and Jennifer Goldman (Editorial)
Critical need for pharmacologic treatment options in NAFLD: A pediatric perspective., Chance S. Friesen, Sherwin S. Chan, Jonathan B. Wagner, Chelsea Hosey-Cojocari, Iván L Csanaky, and Valentina Shakhnovich (Article)
Efficacy of Weight Reduction on Pediatric Nonalcoholic Fatty Liver Disease: Opportunities to Improve Treatment Outcomes Through Pharmacotherapy., Chance S. Friesen, Chelsea Hosey-Cojocari, Sherwin S. Chan, Iván L. Csanaky, Jonathan B. Wagner, Brooke Sweeney, Alec Friesen, Jason D. Fraser, and Valentina Shakhnovich (Article)
Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation., Andrea Gaedigk, Scott T. Casey, Michelle Whirl-Carrillo, Neil A. Miller, and Teri E. Klein (Article)
Scholarly Productivity in Clinical Pharmacology Amid Pandemic-Related Workforce Disruptions: Are Men and Women Affected Equally?, Alethea B. Gerding, Sharon J. Swan, Kimberly A. Brayer, and Susan M. Abdel-Rahman (Editorial)
Analysis Approaches to Identify Pharmacogenetic Associations With Pharmacodynamics., Daniel L. Hertz, Laura B. Ramsey, Mathangi Gopalakrishnan, J Steven Leeder, and Sara L. Van Driest (Article)
Pharmacogenomics Factors Influencing the Effect of Risperidone on Prolactin Levels in Thai Pediatric Patients With Autism Spectrum Disorder., Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Roger Gaedigk, Wiranpat Kittitharaphan, Nattawat Ngamsamut, Penkhae Limsila, Apichaya Puangpetch, Rattanaporn Sukprasong, and Chonlaphat Sukasem (Article)
Relationship between CYP2D6 genotype, activity score and phenotype in a pediatric Thai population treated with risperidone., Yaowaluck Hongkaew, Andrea Gaedigk, Bob Wilffert, Nattawat Ngamsamut, Wiranpat Kittitharaphan, Penkhae Limsila, and Chonlaphat Sukasem (Article)
Resolving discordant CYP2D6 genotyping results in Thai subjects: platform limitations and novel haplotypes, Yaowaluck Hongkaew, Wendy Y. Wang, R Gaedigk, Chonlaphat Sukasem, and Andrea Gaedigk (Article)
Evaluation of Placentation and the Role of the Aryl Hydrocarbon Receptor Pathway in a Rat Model of Dioxin Exposure., Khursheed Iqbal, Stephen H. Pierce, Keisuke Kozai, Pramod Dhakal, Regan L. Scott, Katherine F Roby, Carrie A. Vyhlidal, and Michael J. Soares (Article)
Promoting Culture Change Within Organizations., Bridgette Jones, Catherine Cheng, Lisa M. Foglia, Hope Ricciotti, and Wendi Willis El-Amin (Article)
Methods for Detecting Pediatric Adverse Drug Reactions From the Electronic Medical Record., Lydia M. Joyner, Leah A. Alicea, Jennifer Goldman, Sarah Suppes, and Emma M. Tillman (Article)
DNA methylation perturbations may link altered development and aging in the lung., Priyadarshini Kachroo, Jarrett D. Morrow, Carrie A. Vyhlidal, R Gaedigk, Edwin K. Silverman, Scott T. Weiss, Kelan G. Tantisira, and Dawn L. DeMeo (Article)
Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2C9 and HLA-B Genotypes and Phenytoin Dosing: 2020 Update., Jason H. Karnes, Allan E. Rettie, Andrew A. Somogyi, Rachel Huddart, Alison E. Fohner, Christine M. Formea, Ming Ta Michael Lee, Adrian Llerena, Michelle Whirl-Carrillo, Teri E. Klein, Elizabeth J. Phillips, Scott Mintzer, Andrea Gaedigk, Kelly E. Caudle, and John T. Callaghan (Article)
Clinical Outcome and Antibiotic Dosing Differences by Weight in Children With Acute Osteomyelitis., Kathyrn Kyler, Brian R. Lee, Earl F. Glynn, Joel P Waddell, Mark A. Hoffman, and Jennifer Goldman (Article)
