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Works from 2024

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Advanced Practice Providers in Cellular Therapy: Survey Results from the ASTCT APP Special Interest Group Exploring Clinical Roles, Compensation, and Job Satisfaction., Cory Edgar, Nancy Shreve, Misty D. Evans, Chelsea Honstain, Michelle Skinner, Elizabeth Zerante, Rita Jakubowski, and Kadee Raser (Article)

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Polypyrimidine Tract Binding Protein: A Universal Player in Cancer Development., Elizabeth Gonzalez, Terrie Flatt, Midhat S. Farooqi, Lisa Johnson, and Atif A. Ahmed (Article)

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COVID-19 venous thromboembolism prophylaxis guidelines in pediatrics., Sara McElroy, Emily Cramer, and Lauren Amos MD (Article)

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Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma., Nneka E. Mbah, Amy L. Myers, Peter Sajjakulnukit, Chan Chung, Joyce K. Thompson, Hanna S. Hong, Heather Giza, Derek Dang, Zeribe C. Nwosu, Mengrou Shan, Stefan R. Sweha, Daniella D. Maydan, Brandon Chen, Li Zhang, Brian Magnuson, Zirui Zhu, Megan Radyk, Brooke Lavoie, Viveka Nand Yadav, Imhoi Koo, Andrew D. Patterson, Daniel R. Wahl, Luigi Franchi, Sameer Agnihotri, Carl J. Koschmann, Sriram Venneti, and Costas A. Lyssiotis (Article)

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Microfluidic Affinity Selection of B-Lineage Cells from Peripheral Blood for Minimal Residual Disease Monitoring in Pediatric B-Type Acute Lymphoblastic Leukemia Patients., Malgorzata A. Witek, Nicholas E. Larkey, Alena Bartakova, Mateusz L. Hupert, Shalee Mog, Jami K. Cronin, Judy Vun, Keith August, and Steven A. Soper (Article)

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Final outcomes from a phase 2 trial of posoleucel in allogeneic hematopoietic cell transplant recipients., Sanjeet S. Dadwal, Rajat Bansal, Michael W. Schuster, Jean A. Yared, Douglas Myers, Michelle Matzko, Sama Adnan, David McNeel, Julie Ma, Sarah A. Gilmore, Spyridoula Vasileiou, Ann M. Leen, Joshua A. Hill, and Jo-Anne H. Young (Article)

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Novel thermoplastic microvalves based on an elastomeric cyclic olefin copolymer., Katie Childers, Ian M. Freed, Mateusz L. Hupert, Benjamin Shaw, Noah Larsen, Paul Herring, Jeanne H. Norton, Farhad Shiri, Judy Vun, Keith August, Małgorzata A. Witek, and Steven A. Soper (Article)

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A Genomics Driven Human Induced Pluripotent Stem Cell Model of Infant ALL – Updates on Hematopoietic Differentiation, Meagan Vacek, Jacqelyn Nemechek, Irina Pushel, Priyanka Kumar, Bradley Thornton, Molly Leyda, Midhat Farooqi, Erin Guest, Jay L. Vivian, and John M. Perry (Poster)

Primary Care for Pediatric Cancer Survivors, Robert W Steele and Joy M. Fulbright (Podcast)

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Evaluation of Hi-C Sequencing for Detection of Gene Fusions in Hematologic and Solid Tumor Pediatric Cancer Samples., Anthony D. Schmitt, Kristin Sikkink, Atif A. Ahmed, Shadi Melnyk, Derek Reid, Logan Van Meter, Erin M Guest, Lisa A. Lansdon, Tomi Pastinen, Irina Pushel, Byunggil Yoo, and Midhat S. Farooqi (Article)

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An atypical form of 60S ribosomal subunit in Diamond-Blackfan anemia linked to RPL17 variants., Florence Fellmann, Carol J. Saunders, Marie-Françoise O'Donohue, David W. Reid, Kelsey A. McFadden, Nathalie Montel-Lehry, Cong Yu, Mingyan Fang, Jianguo Zhang, Beryl Royer-Bertrand, Pietro Farinelli, Narjesse Karboul, Jason R. Willer, Lorraine Fievet, Zahurul Alam Bhuiyan, Alissa Lw Kleinhenz, Julie Jadeau, Joy M. Fulbright, Carlo Rivolta, Raffaele Renella, Nicholas Katsanis, Jacques S. Beckmann, Christopher V. Nicchitta, Lydie Da Costa, Erica E. Davis, and Pierre-Emmanuel Gleizes (Article)

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Integrated drug resistance and leukemic stemness gene-expression scores predict outcomes in large cohort of over 3500 AML patients from 10 trials., Abdelrahman H Elsayed, Xueyuan Cao, Richard J. Marrero, Nam H K Nguyen, Huiyun Wu, Yonhui Ni, Raul C. Ribeiro, Herold Tobias, Peter J. Valk, François Béliveau, Guillaume Richard-Carpentier, Josée Hébert, C Michel Zwaan, Alan S. Gamis, Edward Anders Kolb, Richard Aplenc, Todd A. Alonzo, Soheil Meshinchi, Jeffrey Rubnitz, Stanley Pounds, and Jatinder K. Lamba (Article)

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Tailored approach to participant recruitment and retention to maximize health equity in pediatric cancer research., Carolyn R. Bates, Renee M. Gilbert, Kelsey Dean, Keith August, Christie A. Befort, Shallyn Ward, Mary Gibson, and Meredith Dreyer (Article)

Overview of CBC With Diff, Tobie O'Brien, Trisha Williams, and Rebecca Kahler (Podcast)

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Characteristics and treatment of acute myeloid neoplasms with cutaneous involvement in infants up to 6 months of age: A retrospective study., Juliette Renaud, Bianca F. Goemans, Franco Locatelli, Martina Pigazzi, Shelagh Redmond, Claudia E. Kuehni, Alice Destaillats, Todd A. Alonzo, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Raffaele Renella, Todd Cooper, and Francesco Ceppi (Article)

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Optimized cytogenetic risk-group stratification of KMT2A-rearranged pediatric acute myeloid leukemia., Romy E. van Weelderen, Christine J. Harrison, Kim Klein, Yilin Jiang, Jonas Abrahamsson, Todd Alonzo, Richard Aplenc, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Alan S. Gamis, Robert B. Gerbing, Bianca F. Goemans, Hester A. de Groot-Kruseman, Erin M. Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C Michel Zwaan, and Gertjan J L Kaspers (Article)

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Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis., Eric W. Prince, John R. Apps, John Jeang, Keanu Chee, Stephen Medlin, Eric M. Jackson, Roy Dudley, David Limbrick, Robert Naftel, James Johnston, Neil Feldstein, Laura M. Prolo, Kevin Ginn, Toba Niazi, Amy Smith, Lindsay Kilburn, Joshua Chern, Jeffrey Leonard, Sandi Lam, David S. Hersh, Jose Mario Gonzalez-Meljem, Vladimir Amani, Andrew M. Donson, Siddhartha S. Mitra, Pratiti Bandopadhayay, Juan Pedro Martinez-Barbera, and Todd C. Hankinson (Article)

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3D Bioprinting the Tumor Microenvironment for Immunotherapy Development, Molly Leyda, Tykeem Manor, John Szarejko, Douglas Myers, and John M. Perry (Poster)

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Caregiver perceptions of child heath behaviors and weight during treatment for acute lymphoblastic leukemia., Meghan Tokala, Jacee Weber, Renee Gilbert, Meredith Dreyer, Keith August, Christie A Befort, and Carolyn R. Bates (Article)

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"The 10th International MDM2 Workshop": Opening up new avenues for MDM2 and p53 research, the First International MDM2 Workshop in Asia., Rieko Ohki, Koji Itahana, and Tomoo Iwakuma (Article)

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MRD at the end of induction and EFS in T-cell lymphoblastic lymphoma: Children's Oncology Group trial AALL1231., Robert J. Hayashi, Michelle L. Hermiston, Brent L. Wood, David T. Teachey, Meenakshi Devidas, Zhiguo Chen, Robert D. Annett, Barbara L. Asselin, Keith August, Steve Cho, Kimberly P. Dunsmore, Jason Lawrence Freedman, Paul J. Galardy, Paul Harker-Murray, Terzah M. Horton, Alok Jaju, Allison Lam, Yoav H. Messinger, Rodney R. Miles, Maki Okada, Samir Patel, Eric S. Schafer, Tal Schechter, Kristin A. Shimano, Neelam Singh, Amii Steele, Maria L. Sulis, Sarah L. Vargas, Stuart S. Winter, Charlotte Wood, Patrick A. Zweidler-McKay, Mignon L. Loh, Stephen P. Hunger, Elizabeth A. Raetz, Catherine M. Bollard, and Carl E. Allen (Article)

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Prognostic impact of cooccurring mutations in FLT3-ITD pediatric acute myeloid leukemia., Katherine Tarlock, Robert B. Gerbing, Rhonda E. Ries, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Danielle Kirkey, Leila Robinson, Jack H. Peplinksi, Beverly Lange, Todd M. Cooper, Alan S. Gamis, E Anders Kolb, Richard Aplenc, Jessica A. Pollard, Todd A. Alonzo, and Soheil Meshinchi (Article)

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3D Bioprinting the Tumor Microenvironment for Immunotherapy Development, Tykeem Manor, Molly Leyda, John Szarejko, Douglas Myers, and John M. Perry

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Clinical and gene expression data reveal subtypes of pediatric T-cell acute lymphoblastic leukemia, Meghana Bhumireddy, Irina Pushel, Lisa A. Lansdon, Byunggil Yoo, Midhat S. Farooqi, and Keith August

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Fertility Potential and Gonadal Function in Survivors of Reduced-Intensity Hematopoietic Stem Cell Transplantation., Seth J. Rotz, Betty K. Hamilton, Wei Wei, Ibrahim A. Ahmed, Sameeya Ahmed Winston, Sherri Ballard, Robyn J. Bernard, Paul Carpenter, Nosha Farhadfar, Christina Ferraro, Brian D. Friend, Nicholas J. Gloude, Robert J. Hayashi, Kerry Hoyle, Kari Jenssen, Jane Koo, Catherine J. Lee, Livia Mariano, Rawan Nawabit, Alexander Ngwube, Nahal Lalefar, Rachel Phelan, Laynie Perkins, Anandini Rao, Ahmad Rayes, Taryn Sandheinrich, Lauren Stafford, Kathryn Tomlinson, Stacy Whiteside, Christina Wiedl, and Kasiani Myers (Article)

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Shifting perspectives and transformative change: Parent perspectives of an active music engagement intervention for themselves and their child with cancer., Kristin Stegenga, Amanda K. Henley, Elizabeth Harman, and Sheri L. Robb (Article)

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Stability Proteomic Methods To Detect Novel Drug Targets, Whitney M. Nolte, Tomoo Iwakuma, Priscilla Flores-Ascencio, and Alejandro Parrales

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Structural variants involving MLLT10 fusion are associated with adverse outcomes in pediatric acute myeloid leukemia., Oussama Abla, Rhonda E. Ries, Tim Triche, Robert B. Gerbing, Betsy Hirsch, Susana Raimondi, Todd Cooper, Jason E. Farrar, Nathaniel Buteyn, Lauren M. Harmon, Hong Wen, Aniruddha J. Deshpande, E Anders Kolb, Alan S. Gamis, Richard Aplenc, Todd Alonzo, and Soheil Meshinchi (Article)

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Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessment., Michael D. Keller, Patrick J. Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C. Dvorak, Michael R. Verneris, Donald B. Kohn, Sung-Yun Pai, Blachy J. Dávila Saldaña, Benjamin Hanisch, Troy C. Quigg, Roberta H. Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A. Jensen-Wachspress, Christopher A. Lazarski, Gelina Sani, John M. Idso, Haili Lang, Pamela Chansky, Chase D. McCann, Jay Tanna, Allistair A. Abraham, Jennifer L. Webb, Abeer Shibli, Amy K. Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J. Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N. De Oliveira, Mark T. Vander Lugt, Christen L. Ebens, Victor M. Aquino, Jeffrey J. Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T. Zambidis, Elizabeth Gourdine, Catherine M. Bollard, and Michael A. Pulsipher (Article)

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Chromatin Profiles Are Prognostic of Clinical Response to Bortezomib-Containing Chemotherapy in Pediatric Acute Myeloid Leukemia: Results from the COG AAML1031 Trial., Anneke D. van Dijk, Fieke W. Hoff, Yihua Qiu, Stefan E. Hubner, Robin L. Go, Vivian R. Ruvolo, Amanda R. Leonti, Robert B. Gerbing, Alan S. Gamis, Richard Aplenc, Edward A. Kolb, Todd A. Alonzo, Soheil Meshinchi, Eveline S J M de Bont, Terzah M. Horton, and Steven M. Kornblau (Article)

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An Increased Failure Rate of Asparaginase Desensitization with Calaspargase Pegol, Jillian Fry, Erin M. Guest, and Keith J. August (Poster)

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Development and psychometric evaluation of the Symptom Self-Management Behaviors Tool for adolescents/young adults with cancer., Kristin Stegenga, Jeanne M. Erickson, Lauri Linder, Catherine Fiona Macpherson, R K Elswick, and Suzanne Ameringer (Article)

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Diagnosis of Mosaic RASopathy in a Child with Rhabdomyosarcoma, Meagan Vacek, Paige Johnson, Midhat S. Farooqi, Kristi M. Canty, Dihong Zhou, Brendan Lanpher, Wendy Allen-Rhoades, and Erin M. Guest (Poster)

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Early Cholestasis and Vitamin K Deficiency Secondary to Biliary Atresia presenting as Coagulopathy and Thymic Hemorrhage, Abbey Elsbernd and Lauren Amos MD (Poster)

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Increasing Palliative Care Team Involvement in Pediatric Hematopoietic Stem Cell Transplant Patients, Meagan Vacek, Lisa Tarbell, Melissa List, Erin Hall, Jennifer Linebarger, Kelstan Ellis, Gina Jones, and Joel Thompson (Poster)

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Reporting and impact of subsequent cycle toxicities in oncology phase I clinical trials., Avina Rami, Steven G. DuBois, and Kevin Campbell (Article)

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Single Center Retrospective Comparison of Bivalirudin and Heparin for Therapeutic Anticoagulation in Pediatric Patients, Clayton Habiger and Shannon L. Carpenter (Poster)

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Testing for Bleeding Disorders in Child Abuse: Adherence to AAP Recommendations and Results of Testing, Lyndsey Hultman, Angela Doswell, Henry T. Puls, Shannon L. Carpenter, Angela Bachim, Kristine Campbell, Daniel Lindberg, Joanne Wood, and James Anderst (Presentation)

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Association between hemoglobin values and VWF assays: a multicenter investigation., Jillian Simoneau, Cindy Tay, Allison Wheeler, Lauren Amos MD, Meghan McCormick, Yonairy Collado, Megan Brown, and Angela C. Weyand (Letter to the Editor)

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Increased Incidence of TdT-negative Pre-B Acute Lymphoblastic Leukemia Associated With Poor Prognostic Features Among Mexican Children in Central Mexico., Meagan Vacek, Laura C. Zárraga Vargas, Elizabeth González Domínguez, Lilia Garcia Rodriguez, Omar A. Tello Teran, Carlos Mojica Cardoso, Luisa V. Ocampo Roosens, Juan J. Acevedo Fernandez, Weijie Li, Brian R. Lee, Jesús S Olalla Tapia, and Terrie Flatt (Article)

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SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming., Xi Xu, Yanhui Yu, Wenwen Zhang, Weiwei Ma, Chong He, Guo Qiu, Xinyi Wang, Qiong Liu, Minyi Zhao, Jiayi Xie, Fang Tao, John M. Perry, Qifa Liu, Shuan Rao, Xunlei Kang, Meng Zhao, and Linjia Jiang (Article)

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Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers: a Beat Childhood Cancer Research Consortium trial., Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C. Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B. Nagulapally, Karl Dykema, Valerie I Brown, Michael S. Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K. Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K. Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F Halperin, Abigail Moore, Sara A. Byron, William P D Hendricks, and Jeffrey M. Trent (Article)

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Therapeutic potential of combating cancer by restoring wild-type p53 through mRNA nanodelivery., Divya Kamath, Tomoo Iwakuma, and Stefan H. Bossmann (Article)

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Family Rules and Routines During the Early Phases of Pediatric Cancer Treatment: Associations With Child Emotional and Behavioral Health., Carolyn R. Bates, Vincent S. Staggs, Kelsey Dean, Keith August, Christie A. Befort, Lynne Covitz, and Meredith Dreyer (Article)

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A road map for the treatment of pediatric diffuse midline glioma., Carl Koschmann, Wajd N. Al-Holou, Marta M. Alonso, Jamie Anastas, Pratiti Bandopadhayay, Tara Barron, Oren Becher, Rodrigo Cartaxo, Maria G. Castro, Chan Chung, Madison Clausen, Derek Dang, Robert Doherty, Ryan Duchatel, Matthew Dun, Mariella Filbin, Andrea Franson, Stefanie Galban, Marc Garcia Moure, Hugh Garton, Pruthvi Gowda, Joana Graca Marques, Cynthia Hawkins, Allison Heath, Esther Hulleman, Sunjong Ji, Chris Jones, Lindsay Kilburn, Cassie Kline, Michael A. Koldobskiy, Daniel Lim, Pedro R. Lowenstein, Q Richard Lu, Joanna Lum, Stephen Mack, Suresh Magge, Bernard Marini, Donna Martin, Neena Marupudi, Dana Messinger, Rajen Mody, Meredith Morgan, Mateus Mota, Karin Muraszko, Sabine Mueller, Siva Kumar Natarajan, Javad Nazarian, Michael Niculcea, Nicholas Nuechterlein, Hideho Okada, Valerie Opipari, Manjunath P. Pai, Sharmistha Pal, Erik Peterson, Timothy Phoenix, John R. Prensner, Matthew Pun, G Praveen Raju, Zachary J. Reitman, Adam Resnick, David Rogawski, Amanda Saratsis, Stefanie G. Sbergio, Mark Souweidane, James M. Stafford, Theophilos Tzaridis, Sujatha Venkataraman, Orazio Vittorio, Jack Wadden, Daniel Wahl, Robert J. Wechsler-Reya, Viveka Nand Yadav, Xu Zhang, Qiang Zhang, and Sriram Venneti (Article)

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A comprehensive analysis of neuroblastoma incidence, survival, and racial and ethnic disparities from 2001 to 2019., Kevin Campbell, David A. Siegel, Puja J. Umaretiya, Shifan Dai, Andras Heczey, Philip J. Lupo, Jeremy M. Schraw, Trevor D. Thompson, Michael E. Scheurer, and Jennifer H. Foster (Article)

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A modified nucleoside O6-methyl-2'-deoxyguanosine-5'-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner., Zi-Hui Wang, Jin Li, Qian Liu, Jian-Chang Qian, Qing-Qing Li, Qing-Yu Wang, Lv-Tao Zeng, Si-Jia Li, Xin Gao, Jia-Xin Pan, Xu-Fan Gao, Kun Wu, Guo-Xin Hu, Tomoo Iwakuma, and Jian-Ping Cai (Article)

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Use of phosphotyrosine-containing peptides to target SH2 domains: Antagonist peptides of the Crk/CrkL-p130Cas axis., Justin T. Douglas, David K. Johnson, Anuradha Roy, and Taeju Park (Article)

Works from 2023

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Lessons learnt in the first year of an Australian pediatric cardio oncology clinic., Claudia Toro, Ben Felmingham, Mangesh Jhadav, David S. Celermajer, Andre La Gerche, John O'Sullivan, Sanjeev Kumar, Marion K. Mateos, Joy M. Fulbright, Dinisha Govender, Lane Collier, Michael Cheung, David D. Eisenstat, Peter W. Lange, Julian Ayer, David A. Elliott, and Rachel Conyers (Article)

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Colonic L-cell impairment in aged subjects with type 2 diabetes leads to diminished GLP-1 production., Qing-Yu Wang, Wei Zhang, Yue Zhao, Hui-Lian Chen, Qian Liu, Zi-Hui Wang, Lv-Tao Zeng, Jin Li, Si-Jie Chen, Lei Wei, Tomoo Iwakuma, and Jian-Ping Cai (Article)

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Mediators and Moderators of Active Music Engagement to Reduce Traumatic Stress Symptoms and Improve Well-being in Parents of Young Children With Cancer., Sheri L. Robb, Kristin Stegenga, Susan M. Perkins, Timothy E. Stump, Karen M. Moody, Amanda K. Henley, Jessica MacLean, Seethal A. Jacob, David Delgado, and Paul R. Haut (Article)

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Rare Tumors: Opportunities and challenges from the Children's Oncology Group perspective., Kris Ann P. Schultz, Murali Chintagumpala, Jin Piao, Kenneth S. Chen, Rachana Shah, Robyn D. Gartrell, Emily Christison-Lagay, Farzana Pashnakar, Jesse L. Berry, Allison F. O'Neill, Lauren M. Vasta, Ashley Flynn, Sarah G. Mitchell, Brittani Kn Seynnaeve, Jeremy Rosenblum, Samara L. Potter, Junne Kamihara, Carlos Rodriguez-Galindo, Douglas S. Hawkins, and Theodore W. Laetsch (Article)

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Trends in dedicated care for females with bleeding disorders within U.S. hemophilia treatment centers., Allison P. Wheeler, Ming Y. Lim, Patricia S. Huguelet, Julie Jaffray, Janice M. Staber, Kerry Funkhouser, Shannon L. Carpenter, and Angela C. Weyand (Letter to the Editor)

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory., Iker Ausejo-Mauleon, Sara Labiano, Daniel de la Nava, Virginia Laspidea, Marta Zalacain, Lucía Marrodán, Marc García-Moure, Marisol González-Huarriz, Irati Hervás-Corpión, Laasya Dhandapani, Silvestre Vicent, Maria Collantes, Iván Peñuelas, Oren J. Becher, Mariella G. Filbin, Li Jiang, Jenna Labelle, Carlos A O de Biagi-Junior, Javad Nazarian, Sandra Laternser, Timothy N. Phoenix, Jasper van der Lugt, Mariette Kranendonk, Raoull Hoogendijk, Sabine Mueller, Carlos De Andrea, Ana C. Anderson, Elizabeth Guruceaga, Carl Koschmann, Viveka Nand Yadav, Jaime Gállego Pérez-Larraya, Ana Patiño-García, Fernando Pastor, and Marta M. Alonso (Article)

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Clinical Efficacy of ONC201 in H3K27M-Mutant Diffuse Midline Gliomas Is Driven by Disruption of Integrated Metabolic and Epigenetic Pathways., Sriram Venneti, Abed Rahman Kawakibi, Sunjong Ji, Sebastian M. Waszak, Stefan R. Sweha, Mateus Mota, Matthew Pun, Akash Deogharkar, Chan Chung, Rohinton S. Tarapore, Samuel Ramage, Andrew Chi, Patrick Y. Wen, Isabel Arrillaga-Romany, Tracy T. Batchelor, Nicholas A. Butowski, Ashley Sumrall, Nicole Shonka, Rebecca A. Harrison, John de Groot, Minesh Mehta, Matthew D. Hall, Doured Daghistani, Timothy F. Cloughesy, Benjamin M. Ellingson, Kevin Beccaria, Pascale Varlet, Michelle M. Kim, Yoshie Umemura, Hugh Garton, Andrea Franson, Jonathan Schwartz, Rajan Jain, Maureen Kachman, Heidi Baum, Charles F. Burant, Sophie L. Mottl, Rodrigo T. Cartaxo, Vishal John, Dana Messinger, Tingting Qin, Erik Peterson, Peter Sajjakulnukit, Karthik Ravi, Alyssa Waugh, Dustin Walling, Yujie Ding, Ziyun Xia, Anna Schwendeman, Debra Hawes, Fusheng Yang, Alexander R. Judkins, Daniel Wahl, Costas A. Lyssiotis, Daniel de la Nava, Marta M. Alonso, Augustine Eze, Jasper Spitzer, Susanne V. Schmidt, Ryan J. Duchatel, Matthew D. Dun, Jason E. Cain, Li Jiang, Sylwia A. Stopka, Gerard Baquer, Michael S. Regan, Mariella G. Filbin, Nathalie Y R Agar, Lili Zhao, Chandan Kumar-Sinha, Rajen Mody, Arul Chinnaiyan, Ryo Kurokawa, Drew Pratt, Viveka Nand Yadav, Jacques Grill, Cassie Kline, Sabine Mueller, Adam Resnick, Javad Nazarian, Joshua E. Allen, Yazmin Odia, Sharon L. Gardner, and Carl Koschmann (Article)

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Long-term follow-up of patients with congenital thrombotic thrombocytopenia purpura receiving a plasma-derived factor VIII (Koate) that contains ADAMTS13., Tammuella Chrisentery-Singleton, Lisa N. Boggio, Manuel D. Carcao, Sami Ibrahimi, Osman Khan, Arash Mahajerin, Anita Rajasekhar, Vivek Sharma, MacGregor Steele, Marcela Torres, Frank J. Rodino, and Shannon L. Carpenter (Article)

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ROS1 Alterations as a Potential Driver of Gliomas in Infant, Pediatric, and Adult Patients., David M. Meredith, Linda D. Cooley, Adrian Dubuc, Jennifer Morrissette, Robyn T. Sussman, MacLean P. Nasrallah, Pamela Rathbun, Kai Lee Yap, Nitin Wadhwani, Liming Bao, Daynna J. Wolff, Cristiane Ida, Madina Sukhanova, Craig Horbinski, Lawrence J. Jennings, Midhat S. Farooqi, Melissa Gener, Kevin Ginn, Kwok Ling Kam, Koji Sasaki, Rashmi Kanagal-Shamanna, Sanda Alexandrescu, Daniel Brat, and Xinyan Lu (Article)

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Tisagenlecleucel utilisation and outcomes across refractory, first relapse and multiply relapsed B-cell acute lymphoblastic leukemia: a retrospective analysis of real-world patterns., Valentin Barsan, Yimei Li, Snehit Prabhu, Christina Baggott, Khanh Nguyen, Holly Pacenta, Christine L. Phillips, Jenna Rossoff, Heather Stefanski, Julie-An Talano, Amy Moskop, Susanne Baumeister, Michael R. Verneris, Douglas Myers, Nicole A. Karras, Stacy Cooper, Muna Qayed, Michelle Hermiston, Prakash Satwani, Christa Krupski, Amy Keating, Vanessa Fabrizio, Vasant Chinnabhandar, Michael Kunicki, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, and Liora M. Schultz (Article)

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Understanding Macrophage Phagocytosis in Pediatric Leukemia, Molly Leyda, Jacqelyn Nemechek, John Szarejko, Fang Tao, Tykeem Manor, Douglas Myers, and John M. Perry (Poster)

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Valosin-containing protein (VCP/p97) is prognostically unfavorable in pediatric AML, and negatively correlates with unfolded protein response proteins IRE1 and GRP78: A report from the Children's Oncology Group., Fieke W. Hoff, Yihua Qiu, Brandon D. Brown, Robert B. Gerbing, Amanda R. Leonti, Rhonda E. Ries, Alan S. Gamis, Richard Aplenc, Edward Anders Kolb, Todd A. Alonzo, Soheil Meshinchi, Gaye N. Jenkins, Terzah M. Horton, and Steven M. Kornblau (Article)

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Mediport use as an acceptable standard for CAR T cell infusion., Maya Eylon, Snehit Prabhu, Samuel John, Maxwell J M King, Dhruv Bhatt, Kevin J. Curran, Courtney Erickson, Nicole A. Karras, Christine L. Phillips, Prakash Satwani, Michelle Hermiston, Erica Southworth, Susanne H C Baumeister, Julie-An Talano, Margaret L. MacMillan, Jenna Rossoff, Challice L. Bonifant, Douglas Myers, Rayne H. Rouce, Keri Toner, Timothy A. Driscoll, Emmanuel Katsanis, Dana B. Salzberg, Deborah Schiff, Satiro N. De Oliveira, Christian M. Capitini, Holly L. Pacenta, Thomas Pfeiffer, Niketa C. Shah, Van Huynh, Jodi L. Skiles, Ellen Fraint, Kevin O. McNerney, Troy C. Quigg, Joerg Krueger, John A. Ligon, Vanessa A. Fabrizio, Christina Baggott, Theodore W. Laetsch, and Liora M. Schultz (Article)

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Editorial: Stem cells and the immune system., John M. Perry and Meng Zhao (Editorial)

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Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis., Sara Zarnegar-Lumley, Todd A. Alonzo, Robert B. Gerbing, Megan Othus, Zhuoxin Sun, Rhonda E. Ries, Jim Wang, Amanda Leonti, Matthew A. Kutny, Fabiana Ostronoff, Jerald P. Radich, Frederick R. Appelbaum, Era L. Pogosova-Agadjanyan, Kristen O'Dwyer, Martin S. Tallman, Mark Litzow, Ehab Atallah, Todd M. Cooper, Richard A. Aplenc, Omar Abdel-Wahab, Alan S. Gamis, Selina Luger, Harry Erba, Ross Levine, E Anders Kolb, Derek L. Stirewalt, Soheil Meshinchi, and Katherine Tarlock (Article)

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Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma., Soumya M. Turaga, Vikalp Vishwakarma, Stacey L. Hembruff, Benjamin K. Gibbs, Priya Sabu, Rajni V. Puri, Harsh B. Pathak, Glenson Samuel, and Andrew K. Godwin (Article)

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Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development, Bingruo Wu, Brian Wu, Sonia Benkaci, Lijie Shi, Pengfei Lu, Taeju Park, Bernice E. Morrow, Yidong Wang, and Bin Zhou (Article)

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Characterization of an Mtbp Hypomorphic Allele in a Diethylnitrosamine-Induced Liver Carcinogenesis Model, Atul Ranjan, Elizabeth A. Thoenen, Atsushi Kaida, Stephanie Wood, Terry Van Dyke, and Tomoo Iwakuma (Article)

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A Genomics Driven Pluripotent Stem Cell Model of Infant Acute Lymphoblastic Leukemia, Meagan Vacek, Jacqelyn Nemechek, Julia Draper, Irina Pushel, Bradley Thornton, Molly Leyda, Priyanka Prem Kumar, Midhat S. Farooqi, Jay L. Vivian, Erin M. Guest, and John M. Perry (Poster)

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A phase II trial of nifurtimox combined with topotecan and cyclophosphamide for refractory or relapsed neuroblastoma and medulloblastoma., Don Eslin, Peter E Zage, Genevieve Bergendahl, Elizabeth Lewis, William Roberts, Jacqueline Kraveka, Deanna Mitchell, Michael S. Isakoff, Jawhar Rawwas, Randal K. Wada, Mark Fluchel, Valerie I. Brown, Kevin Ginn, Timothy Higgins, Abhinav BeeravallyNagulapally, Karl Dykema, Gina Hanna, William Ferguson, and Giselle L. Saulnier Sholler (Article)

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CD19-negative B-cell precursors in bone marrow: A potential mimicker for CD19-negative B-lymphoblastic leukemia by flow cytometry in patients with anti-CD19 treatment., Weijie Li, Ruth Morgan, Roxanne Nieder, Sahibu Sultan M Habeebu, and Douglas Myers (Article)

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Evaluation of venous thromboembolism risk factors reveals subtype heterogenicity in children with central venous catheters: a multicenter study from the Children's Hospital Acquired Thrombosis consortium., Julie Jaffray, Maua Mosha, Brian Branchford, Neil A. Goldenberg, Michael Silvey, Stacy E. Croteau, John H. Fargo, James D. Cooper, Nihal Bakeer, Amy Stillings, Emily Krava, Guy Young, and Ernest K. Amankwah (Article)

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Minimal residual disease predicts outcomes in KMT2A-rearranged but not KMT2A-germline infant acute lymphoblastic leukemia: Report from Children's Oncology Group study AALL0631., Kelly E. Faulk, John A. Kairalla, ZoAnn E. Dreyer, Andrew J. Carroll, Nyla A. Heerema, Meenakshi Devidas, William L. Carroll, Elizabeth A. Raetz, Mignon L. Loh, Stephen P. Hunger, Michael Borowitz, Cindy Wang, Erin M. Guest, and Patrick A. Brown (Article)

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Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia, Eline J M Bertrums, Jenny L. Smith, Lauren Harmon, Rhonda E. Ries, Yi-Cheng J. Wang, Todd A. Alonzo, Andrew J. Menssen, Karen M. Chisholm, Amanda R. Leonti, Katherine Tarlock, Fabiana Ostronoff, Era L. Pogosova-Agadjanyan, Gertjan J L Kaspers, Henrik Hasle, Michael Dworzak, Christiane Walter, Nora Muhlegger, Cristina Morerio, Laura Pardo, Betsy Hirsch, Susana Raimondi, Todd M. Cooper, Richard Aplenc, Alan S. Gamis, Edward A. Kolb, Jason E. Farrar, Derek Stirewalt, Xiaotu Ma, Tim I. Shaw, Scott N. Furlan, Lisa Eidenschink Brodersen, Michael R. Loken, Marry M. Van den Heuvel-Eibrink, C Michel Zwaan, Timothy J. Triche, Bianca F. Goemans, and Soheil Meshinchi (Article)

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SARS-CoV-2 infections in patients enrolled on the Children's Oncology Group standard-risk B-cell acute lymphoblastic leukemia trial, AALL1731., Caitlin W. Elgarten, John A. Kairalla, Joel Thompson, Tamara P. Miller, Cindy Wang, Susan Conway, Mignon L. Loh, Elizabeth A. Raetz, Sumit Gupta, Rachel E. Rau, Anne Angiolillo, Karen R. Rabin, and Sarah Alexander (Article)

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Management and outcomes in secondary diabetes among pediatric patients hospitalized with hemophagocytic lymphohistiocytosis., Cintya Schweisberger, Nila Palaniappan, Nicole Wood, Lauren Amos MD, and Kelsee Halpin (Article)

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Humoral and cellular response to the COVID-19 vaccine in immunocompromised children., Heather A. Morgans, Todd Bradley, Linda Flebbe-Rehwaldt, Rangaraj Selvarangan, Amber Bagherian, Aliessa P. Barnes, Julie A. Bass, Ashley M. Cooper, Ryan T. Fischer, Steve Kleiboeker, Brian R. Lee, Cas LeMaster, Kelsey Markus, Stephen Morrison, Angela Myers, Douglas Myers, Erin Payne, Jennifer E. Schuster, Sarah Standley, Andrea B. Wieser, and Bradley A. Warady (Article)

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HLH-like toxicities predict poor survival after the use of tisagenlecleucel in children and young adults with B-ALL., Kevin O. McNerney, Stephanie J. Si Lim, Kyle Ishikawa, Alexandra Dreyzin, Anant Vatsayan, John J. Chen, Christina Baggott, Snehit Prabhu, Holly L. Pacenta, Christine Philips, Jenna Rossoff, Heather E. Stefanski, Julie-An Talano, Amy Moskop, Michael Verneris, Douglas Myers, Nicole A. Karras, Patrick Brown, Challice L. Bonifant, Muna Qayed, Michelle Hermiston, Prakash Satwani, Christa Krupski, Amy K. Keating, Susanne H C Baumeister, Vanessa A. Fabrizio, Vasant Chinnabhandar, Emily Egeler, Sharon Mavroukakis, Kevin J. Curran, Crystal L. Mackall, Theodore W. Laetsch, and Liora M. Schultz (Article)

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Prevalence of Iron Deficiency in Patients with Inherited Bleeding Disorders, Thomas Cochran, Brian R. Lee, and Shannon L. Carpenter (Poster)

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Real-Time Quantitative Measurement of Tumor Cell Migration and Invasion Following Synthetic mRNA Transfection., Taeju Park and Neka Large (Article)

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Editorial: Genetic and epigenetic regulation of stem cells by the immune system in homeostasis, regeneration, and oncogenesis., John M. Perry and Pengxu Qian (Editorial)

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Switching from Sucrose-Formulated rFVIII to Octocog Alfa (BAY 81-8973) Prophylaxis Improves Bleed Outcomes in the LEOPOLD Clinical Trials., Gili Kenet, Thomas Moulton, Brian M. Wicklund, Sanjay P. Ahuja, Miguel Escobar, and Johnny Mahlangu (Article)

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Integrated genetic profiling of archival pediatric high-grade glial tumors and reassessment with 2021 WHO classification of paediatric CNS tumours, Linda D. Cooley, Lisa A. Lansdon, Kris Laurence, John Herriges, Lei Zhang, Elena Repnikova, Julie M. Joyce, Preeti Thakor, Lisa Warren, Scott C. Smith, Byunggil Yoo, Melissa Gener, Kevin Ginn, and Midhat S. Farooqi (Article)

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Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia., Jason E. Farrar, Jenny L. Smith, Megan Othus, Benjamin J. Huang, Yi-Cheng Wang, Rhonda Ries, Tiffany Hylkema, Era L. Pogosova-Agadjanyan, Sneha Challa, Amanda Leonti, Timothy I. Shaw, Timothy J. Triche, Alan S. Gamis, Richard Aplenc, E Anders Kolb, Xiaotu Ma, Derek L. Stirewalt, Todd A. Alonzo, and Soheil Meshinchi (Article)

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Measurable Residual Disease and Fusion Partner Independently Predict Survival and Relapse Risk in Childhood KMT2A-Rearranged Acute Myeloid Leukemia: A Study by the International Berlin-Frankfurt-Münster Study Group, Romy E. van Weelderen, Kim Klein, Christine J. Harrison, Yilin Jiang, Jonas Abrahamsson, Nira Arad-Cohen, Emmanuelle Bart-Delabesse, Barbara Buldini, Barbara De Moerloose, Michael N. Dworzak, Sarah Elitzur, José M. Fernández Navarro, Robert B. Gerbing, Bianca F. Goemans, Hester A. de Groot-Kruseman, Erin M. Guest, Shau-Yin Ha, Henrik Hasle, Charikleia Kelaidi, Hélène Lapillonne, Guy Leverger, Franco Locatelli, Riccardo Masetti, Takako Miyamura, Ulrika Norén-Nyström, Sophia Polychronopoulou, Mareike Rasche, Jeffrey E. Rubnitz, Jan Stary, Anne Tierens, Daisuke Tomizawa, C Michel Zwaan, and Gertjan J L Kaspers (Article)

A genomics driven pluripotent stem cell model of infant acute lymphoblastic leukemia, Jacqelyn Nemechek, Julia Draper, Sarah McDermott, Irina Pushel, Midhat S. Farooqi, Erin M. Guest, John M. Perry, and Jay L. Vivian

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A Pediatric Case of Treatment-related Myelodysplastic Syndrome While on Therapy for Pre-B Acute Lymphoblastic Leukemia., Sara McElroy, Douglas Myers, and Terrie Flatt (Article)

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A Pilot Study of Azacitidine as Epigenetic Priming for Chemotherapy in Infants Less Than 1 Year of Age with KMT2A-Rearranged Acute Lymphoblastic Leukemia (ALL); Results from the Children’s Oncology Group (COG) Trial AALL15P1, Erin M. Guest, John Kairalla, Meenakshi Devidas, Emily Hibbitts, Andrew Carroll, Nyla A. Heerema, Holly Kubaney, Amanda August, Melinda Pauly, Daniel Wechsler, Rodney Miles, Joel Reid, Cynthia Kihei, Lia Gore, Elizabeth Raetz, Stephen Hunger, Mignon Loh, and Patrick Brown

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Bone Marrow Transplant For Macrophage Activation Syndrome In Systemic Juvenile Idiopathic Arthritis​, Shailly Gaur, Michael J. Holland, J Allyson Hays, and Ibrahim A. Ahmed (Poster)

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Interaction between Crk and β-III spectrin during brain development and neurodegeneration, Shufei Zhuang, Jay L. Vivian, David K. Johnson, Lance Rodan, Tom Curran, and Taeju Park

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Macrophage Mediated Cancer Cell Targeting, Molly Leyda, Jacqelyn Nemechek, John Szarejko, John M. Perry, and Douglas Myers

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Overexpression of Crk and CrkL Increases the Motility of High-Grade Glioma Cells, Neka Large and Taeju Park

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p53 genetic sensor system to identify novel mutant p53 reactivators, Mrinalini Bhosale, Alejandro Parrales, Mohamed A.A. Alalem, Atul Ranjan, Elizabeth Thoenen, and Tomoo Iwakuma

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Pathologic, cytogenetic, and molecular features of acute myeloid leukemia with megakaryocytic differentiation: A report from the Children's Oncology Group., Karen M. Chisholm, Jenny Smith, Amy E. Heerema-McKenney, John K. Choi, Rhonda E. Ries, Betsy A. Hirsch, Susana C. Raimondi, Yi-Cheng Wang, Alice Dang, Todd A. Alonzo, Lillian Sung, Richard Aplenc, Alan S. Gamis, Soheil Meshinchi, and Samir B. Kahwash (Article)

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Skin Toxicity Due to Mercaptopurine in Maintenance Therapy Among Children With Acute Lymphoblastic Leukemia., Kayeleigh Higgerson and Terrie Flatt (Article)

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Stem Like T Cells in Anti-cancer Immunosurveillance Against Therapy-resistant Pediatric Cancer, Fang Tao, Sara McElroy, Jacqelyn Nemechek, Irina Pushel, Santosh Khanal, John Szarejko, Todd Bradley, Douglas Myers, and John M. Perry

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Therapeutic targeting of prenatal pontine ID1 signaling in DMG, Dana Messinger, Garrett Gibson, Micah K. Harris, Jessica R. Cummings, Chase Thomas, Tao Yang, Stefan R. Sweha, Rinette Woo, Robert Siddaway, Martin Burkert, Stefanie Stallard, Tingting Qin, Brendan Mullan, Ruby Siada, Ramya Ravindran, Michael Niculcea, Abigail Dowling, Joshua Bradin, Kevin F. Ginn, Melissa A H Gener, Kathleen Dorris, Nicholas A. Vitanza, Susanne V. Schmidt, Cynthia Hawkins, Sebastian M. Waszak, Sriram Venneti, and Viveka Nand Yadav

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Identification of small extracellular vesicle protein biomarkers for pediatric Ewing Sarcoma., Soumya M. Turaga, Mihaela E. Sardiu, Vikalp Vishwakarma, Amrita Mitra, Leonidas E. Bantis, Rashna Madan, Michael L. Merchant, Jon B. Klein, Glenson Samuel, and Andrew K. Godwin (Article)

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Perinucleolar Compartment (PNC) Prevalence as an Independent Prognostic Factor in Pediatric Ewing Sarcoma: A Multi-Institutional Study., Elizabeth Gonzalez, Atif A. Ahmed, Laura McCarthy, Katherine Chastain, Sahibu Sultan M Habeebu, Marta Zapata-Tarres, Rocio Cardenas-Cardos, Liliana Velasco-Hidalgo, Celso Corcuera-Delgado, Rodolfo Rodriguez-Jurado, Lilia García-Rodríguez, Alejandro Parrales, Tomoo Iwakuma, Midhat S. Farooqi, Brian R. Lee, Scott J. Weir, and Terrie Flatt (Article)

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More than a baby step toward improved treatment: Commentary on "NEOnatal Central-venous Line Observational study on Thrombosis (NEOCLOT): evaluation of a national guideline on management of neonatal catheter-related venous thrombosis"., Shannon L. Carpenter (Article)

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Outcomes of Infants and Young Children With Relapsed Medulloblastoma After Initial Craniospinal Irradiation-Sparing Approaches: An International Cohort Study., Craig Erker, Martin Mynarek, Simon Bailey, Claire M. Mazewski, Lorena Baroni, Maura Massimino, Juliette Hukin, Dolly Aguilera, Andrea M. Cappellano, Vijay Ramaswamy, Alvaro Lassaletta, Sébastien Perreault, Cassie N. Kline, Revathi Rajagopal, George Michaiel, Michal Zapotocky, Vicente Santa-Maria Lopez, Andres Morales La Madrid, Chantel Cacciotti, Eric S. Sandler, Lindsey M. Hoffman, Darren Klawinski, Sara Khan, Ralph Salloum, Anna L. Hoppmann, Valérie Larouche, Kathleen Dorris, Helen Toledano, Stephen W. Gilheeney, Mohamed S. Abdelbaki, Beverly Wilson, Derek S. Tsang, Jeffrey Knipstein, Michal Yalon Oren, Shafqat Shah, Jeffrey C. Murray, Kevin Ginn, Zhihong J. Wang, Gudrun Fleischhack, Denise Obrecht, Svenja Tonn, Virginia L. Harrod, Kara Matheson, Bruce Crooks, Douglas R. Strother, Kenneth J. Cohen, Jordan R. Hansford, Sabine Mueller, Ashley Margol, Amar Gajjar, Girish Dhall, Jonathan L. Finlay, Paul A. Northcott, Stefan Rutkowski, Steven C. Clifford, Giles Robinson, Eric Bouffet, and Lucie Lafay-Cousin (Article)

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Standardization of Fertility Preservation Discussion Among Pediatric Oncology and Bone Marrow Transplant Patients: A Single Institution Experience., Chandni Dargan, Sarah Mc Dermott, Shelby Chesbro, Amanda Trout, Nancy Terwilliger, Tennille Hilyard, Ashley Flynn, and Joy M. Fulbright (Article)